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@ARTICLE{Karpinski:305581,
      author       = {M. J. Karpinski$^*$ and S. Hoberück and W. P. Fendler$^*$
                      and C. Civan$^*$ and R. A. Bundschuh and C. Thomas and A.
                      Bjartell and E. Trägårdh and T. F. W. Soeterik and L.
                      Evangelista and A. Vondrak and S. Rasul and L. Forner$^*$
                      and A. D. Giorgio and H. Scholtissek and J. Miksch and A.
                      Holzgreve and F. Lanfranchi and K. Rahbar and M. S. Hofman
                      and I. Rauscher and O. Güven and M. Eiber and N. Ayati and
                      L. Umutlu and K. Herrmann$^*$ and B. Hadaschik$^*$ and L.
                      Emmett},
      title        = {{A}ssociation {B}etween the {PRIMARY} {S}core at {S}taging
                      {P}rostate-specific {M}embrane {A}ntigen {P}ositron
                      {E}mission {T}omography and {O}verall {S}urvival {A}mong
                      {P}atients with {N}ewly {D}iagnosed {P}rostate {C}ancer:
                      {F}indings from the {I}nternational, {M}ulticenter {PROMISE}
                      {R}egistry.},
      journal      = {European urology},
      volume       = {nn},
      issn         = {0302-2838},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DKFZ-2025-02240},
      pages        = {nn},
      year         = {2025},
      note         = {epub / brief report},
      abstract     = {The PRIMARY score was implemented in Prostate Cancer
                      Molecular Imaging Standardized Evaluation (PROMISE) version
                      2 to improve accuracy for the diagnosis of clinically
                      significant prostate cancer using prostate-specific membrane
                      antigen (PSMA) positron emission tomography (PET). We
                      reviewed overall survival (OS) for patients who underwent
                      PSMA PET for initial staging to evaluate the prognostic
                      value of PRIMARY in a large, international, multicenter
                      cohort. The cohort comprised 1889 patients who underwent
                      PSMA PET for initial staging of prostate cancer at
                      investigator sites across Europe and Australia between 2012
                      and 2021. Hazard ratios (HRs) with $95\%$ confidence
                      interval (CI) were calculated for PRIMARY scores to identify
                      predictors of OS. Complete-case head-to-head comparisons
                      were conducted for Prostate Imaging-Reporting and Data
                      System (PI-RADS) versus PRIMARY scores, and cT stage versus
                      PRIMARY scores. We present preliminary findings up to
                      January 31, 2025, when 231 deaths had occurred. PRIMARY
                      score 5 (HR 1.5, $95\%$ CI 1.0-2.3; p = 0.045) was
                      associated with shorter OS. Improvements in C index values
                      confirmed the added prognostic value of the PRIMARY score
                      when combined with PI-RADS or cT stage. PRIMARY score 5 on
                      initial PSMA PET is prognostic for shorter OS. There is
                      ongoing long-term follow-up in the PROMISE registry
                      (NCT06320223, promise-pet.org).},
      keywords     = {Overall survival (Other) / PRIMARY score (Other) / Positron
                      emission tomography (Other) / Prostate cancer (Other) /
                      Prostate-specific membrane antigen (Other)},
      cin          = {ED01},
      ddc          = {610},
      cid          = {I:(DE-He78)ED01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41168067},
      doi          = {10.1016/j.eururo.2025.10.013},
      url          = {https://inrepo02.dkfz.de/record/305581},
}