%0 Journal Article
%A Djaileb, Loïc
%A Farolfi, Andrea
%A Rauscher, Isabel
%A Haghighatian, Mahan
%A Mercier, Alexis
%A Fendler, Wolfgang P
%A Hadaschik, Boris
%A Herrmann, Ken
%A Solnes, Lilja B
%A Rettig, Matthew
%A Weber, Manuel
%A Czernin, Johannes
%A Calais, Jeremie
%A Benz, Matthias R
%A Eiber, Matthias
%A Gafita, Andrei
%T Clinical Impact of Changes in Tumor Uptake and Volume on PSMA PET/CT During [177Lu]Lu-PSMA Therapy in Metastatic Castration-Resistant Prostate Cancer.
%J Journal of nuclear medicine
%V nn
%@ 0097-9058
%C New York, NY
%I Soc.
%M DKFZ-2025-02242
%P nn
%D 2025
%Z epub / brief communication
%X Although tumor volume and new lesions (NLs) have been investigated previously as measures of response, the clinical impact of changes in tumor uptake on prostate-specific membrane antigen (PSMA) PET remains largely unknown. Methods: This multicenter retrospective study investigated the clinical impact of changes in tumor uptake and volume on PSMA PET during [177Lu]Lu-PSMA in metastatic castration-resistant prostate cancer (mCRPC). The primary outcomes were the associations of changes in SUVmax (ΔSUVmax) and SUVmean (ΔSUVmean), changes in total tumor volume (ΔTTV), and occurrence of NLs with prostate-specific antigen (PSA) progression-free survival (PSA-PFS) and overall survival (OS). The study included patients with mCRPC who received [177Lu]Lu-PSMA between 2014 and 2019. PSMA PET/CT was performed at baseline and after 2 cycles of therapy. Whole-body analyses (SUVmax, SUVmean, TTV, and NLs) were performed and calculated using qPSMA software. Results: In total, 124 patients with mCRPC (median age, 73 y; interquartile range, 67-76 y) were included in the study. Whole-body ΔTTV and the occurrence of NLs were significantly associated with shorter PSA-PFS (hazard ratio [HR], 5.7; 95
%K LuPSMA (Other)
%K PSMA PET (Other)
%K RECIP (Other)
%K metastatic castration-resistant prostate cancer (Other)
%K radiopharmaceutical therapy (Other)
%K response evaluation (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:41167722
%R 10.2967/jnumed.125.270239
%U https://inrepo02.dkfz.de/record/305583