%0 Journal Article
%A Taugner, Julian
%A Stamer, Silja
%A Hofstetter, Kerstin
%A Eze, Chukwuka
%A Käsmann, Lukas
%A Clasen, Kerstin
%A Hartig, Philipp
%A Spengler, Werner
%A Groß, Thorben
%A Manapov, Farkhad
%A Belka, Claus
%A Niyazi, Maximilian
%T Immune checkpoint inhibition alters patterns of failure in inoperable stage III non-small cell lung cancer patients treated with chemoradiotherapy.
%J Journal of cancer research and clinical oncology
%V 151
%N 12
%@ 0301-1585
%C Heidelberg
%I Springer
%M DKFZ-2025-02257
%P 313
%D 2025
%X We compared failure patterns in patients with inoperable stage III non-small cell lung cancer (NSCLC) treated with chemoradiotherapy (CRT) alone versus CRT combined with sequential and/or concurrent immune checkpoint inhibitors (CRT-IO).Retrospective real-world data from 221 patients across two German tertiary cancer centers were analyzed. Of these, 74 received CRT-IO, including sequential durvalumab (85
%K Humans
%K Carcinoma, Non-Small-Cell Lung: therapy
%K Carcinoma, Non-Small-Cell Lung: pathology
%K Carcinoma, Non-Small-Cell Lung: drug therapy
%K Carcinoma, Non-Small-Cell Lung: mortality
%K Carcinoma, Non-Small-Cell Lung: immunology
%K Female
%K Male
%K Immune Checkpoint Inhibitors: therapeutic use
%K Immune Checkpoint Inhibitors: administration & dosage
%K Lung Neoplasms: pathology
%K Lung Neoplasms: therapy
%K Lung Neoplasms: drug therapy
%K Lung Neoplasms: mortality
%K Lung Neoplasms: immunology
%K Aged
%K Middle Aged
%K Retrospective Studies
%K Chemoradiotherapy: methods
%K Neoplasm Staging
%K Adult
%K Aged, 80 and over
%K Treatment Failure
%K Nivolumab: administration & dosage
%K Antineoplastic Combined Chemotherapy Protocols: therapeutic use
%K Antibodies, Monoclonal
%K Chemoradiotherapy (Other)
%K Immunotherapy (Other)
%K Lung cancer (Other)
%K NSCLC (Other)
%K Patterns-of-failure (Other)
%K Immune Checkpoint Inhibitors (NLM Chemicals)
%K Nivolumab (NLM Chemicals)
%K durvalumab (NLM Chemicals)
%K Antibodies, Monoclonal (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:41175229
%R 10.1007/s00432-025-06355-y
%U https://inrepo02.dkfz.de/record/305607