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@ARTICLE{Gustafsson:305610,
      author       = {K. Gustafsson and S. Isaev and K. Mirsanaye and J. Hofmann
                      and K. A. Kooshesh and N. Baryawno and A. Kiem and N. Severe
                      and T. Zhao and E. W. Scadden and J. A. Spencer and C. Burns
                      and K. Akilan and N. Barkas and H. Gessessew and K.
                      Kokkaliaris$^*$ and C. P. Lin and P. V. Kharchenko and D. T.
                      Scadden},
      title        = {{M}esenchymal thymic niche cells enable regeneration of the
                      adult thymus and {T} cell immunity.},
      journal      = {Nature biotechnology},
      volume       = {nn},
      issn         = {1087-0156},
      address      = {New York, NY},
      publisher    = {Springer Nature},
      reportid     = {DKFZ-2025-02260},
      pages        = {nn},
      year         = {2025},
      note         = {epub},
      abstract     = {Thymic atrophy and the progressive immune decline that
                      accompanies it is a major health problem, chronically with
                      age and acutely with immune injury. No definitive solution
                      is available. Here we demonstrate that one of the three
                      mesenchymal cell subsets identified by single-cell analysis
                      of human and mouse thymic stroma is a critical niche
                      component for T lymphopoiesis. The Postn+ subset is
                      perivascular, and its depletion abrogates T cell progenitor
                      recruitment, likely through production of the chemokine
                      Ccl19. It markedly declines with age and in the acute
                      setting of hematopoietic stem cell transplant conditioning.
                      When isolated and adoptively transferred, Postn+ cells
                      durably engraft the atrophic thymus, recruit early T
                      progenitors, increase T cell neogenesis and enhance T cell
                      response to vaccination. More readily available mesenchymal
                      populations expressing Ccl19 provide similar effects. These
                      data define a thymus lymphopoietic niche cell type that may
                      be manipulated therapeutically to regenerate T
                      lymphopoiesis.},
      cin          = {FM01},
      ddc          = {660},
      cid          = {I:(DE-He78)FM01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41168496},
      doi          = {10.1038/s41587-025-02864-w},
      url          = {https://inrepo02.dkfz.de/record/305610},
}