%0 Journal Article
%A Denk, Dominic
%A Singh, Anurag
%A Kasler, Herbert G
%A D'Amico, Davide
%A Rey, Julia
%A Alcober-Boquet, Lucía
%A Gorol, Johanna M
%A Steup, Christoph
%A Tiwari, Ritesh
%A Kwok, Ryan
%A Argüello, Rafael J
%A Faitg, Julie
%A Sprinzl, Kathrin
%A Zeuzem, Stefan
%A Nekljudova, Valentina
%A Loibl, Sibylle
%A Verdin, Eric
%A Rinsch, Chris
%A Greten, Florian R
%T Effect of the mitophagy inducer urolithin A on age-related immune decline: a randomized, placebo-controlled trial.
%J Nature aging
%V 5
%N 11
%@ 2662-8465
%C London
%I Nature Research
%M DKFZ-2025-02263
%P 2309-2322
%D 2025
%Z 2025 Nov;5(11):2309-2322
%X Mitochondrial dysfunction and stem cell exhaustion contribute to age-related immune decline, yet clinical interventions targeting immune aging are lacking. Recently, we demonstrated that urolithin A (UA), a mitophagy inducer, expands T memory stem cells (TSCM) and naive T cells in mice. In this randomized, double-blind, placebo-controlled trial, 50 healthy middle-aged adults received oral UA (1,000 mg day-1) or placebo for 4 weeks; time points of analysis were baseline and day 28. Primary outcomes were phenotypical changes in peripheral CD3+ T cell subsets and immune metabolic remodeling. UA expanded peripheral naive-like, less terminally exhausted CD8+ cells (treatment difference 0.50 percentage points; 95
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:41174221
%R 10.1038/s43587-025-00996-x
%U https://inrepo02.dkfz.de/record/305613