TY  - JOUR
AU  - Denk, Dominic
AU  - Singh, Anurag
AU  - Kasler, Herbert G
AU  - D'Amico, Davide
AU  - Rey, Julia
AU  - Alcober-Boquet, Lucía
AU  - Gorol, Johanna M
AU  - Steup, Christoph
AU  - Tiwari, Ritesh
AU  - Kwok, Ryan
AU  - Argüello, Rafael J
AU  - Faitg, Julie
AU  - Sprinzl, Kathrin
AU  - Zeuzem, Stefan
AU  - Nekljudova, Valentina
AU  - Loibl, Sibylle
AU  - Verdin, Eric
AU  - Rinsch, Chris
AU  - Greten, Florian R
TI  - Effect of the mitophagy inducer urolithin A on age-related immune decline: a randomized, placebo-controlled trial.
JO  - Nature aging
VL  - 5
IS  - 11
SN  - 2662-8465
CY  - London
PB  - Nature Research
M1  - DKFZ-2025-02263
SP  - 2309-2322
PY  - 2025
N1  - 2025 Nov;5(11):2309-2322
AB  - Mitochondrial dysfunction and stem cell exhaustion contribute to age-related immune decline, yet clinical interventions targeting immune aging are lacking. Recently, we demonstrated that urolithin A (UA), a mitophagy inducer, expands T memory stem cells (TSCM) and naive T cells in mice. In this randomized, double-blind, placebo-controlled trial, 50 healthy middle-aged adults received oral UA (1,000 mg day-1) or placebo for 4 weeks; time points of analysis were baseline and day 28. Primary outcomes were phenotypical changes in peripheral CD3+ T cell subsets and immune metabolic remodeling. UA expanded peripheral naive-like, less terminally exhausted CD8+ cells (treatment difference 0.50 percentage points; 95
LB  - PUB:(DE-HGF)16
C6  - pmid:41174221
DO  - DOI:10.1038/s43587-025-00996-x
UR  - https://inrepo02.dkfz.de/record/305613
ER  -