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@ARTICLE{Jahn:305743,
      author       = {A. Jahn$^*$ and C. Heining$^*$ and S. Fröhling$^*$ and H.
                      Glimm$^*$ and E. Schröck$^*$},
      title        = {{T}argeted therapy in patients with genetic tumor
                      syndromes.},
      journal      = {Medizinische Genetik},
      volume       = {37},
      number       = {4},
      issn         = {0936-5931},
      address      = {Berlin},
      publisher    = {de Gruyter},
      reportid     = {DKFZ-2025-02366},
      pages        = {321 - 335},
      year         = {2025},
      abstract     = {Significant progress in comprehensive molecular diagnostics
                      and targeted therapies for advanced malignancies has, in
                      part, led to substantial improvements in patient outcomes.
                      Nevertheless, comprehensive genomic profiling necessitates
                      interdisciplinary discussion of potential clinical
                      recommendations within interdisciplinary molecular tumor
                      boards. (Likely) pathogenic germline variants (PGVs)
                      typically warrant genetic counseling for patients and, where
                      appropriate, their relatives. Concurrently, the rapidly
                      expanding availability of targeted therapies introduces new
                      therapeutic implications based on germline alterations that
                      must be integrated into clinical decision-making. Moreover,
                      the identification of PGVs may not only inform therapy in
                      patients with manifest malignancy but also offer
                      opportunities for targeted chemoprevention.},
      keywords     = {Precision oncology (Other) / biomarker-targeted therapy
                      (Other) / clinical trials (Other) / genetic testing and
                      prevention (Other) / genetic tumor syndrome (Other)},
      cin          = {DD01 / B340},
      ddc          = {610},
      cid          = {I:(DE-He78)DD01-20160331 / I:(DE-He78)B340-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41210226},
      pmc          = {pmc:PMC12594532},
      doi          = {10.1515/medgen-2025-2045},
      url          = {https://inrepo02.dkfz.de/record/305743},
}