%0 Journal Article
%A Al-Monajjed, Rouvier
%A Boschheidgen, Matthias
%A Lakes, Jale
%A Krilaviciute, Agne
%A Radtke, Jan-Philipp
%A Schlemmer, Heinz-Peter
%A Bonekamp, David
%A Herkommer, Kathleen
%A Jahnen, Matthias
%A Gschwend, Jürgen E
%A Düx, Daniel
%A Wacker, Frank
%A Makowski, Marcus R
%A Sauter, Andreas
%A Kuczyk, Markus A
%A Harke, Nina
%A Debus, Jürgen
%A Grott, Christoph
%A Arsov, Christian
%A Seibold, Petra
%A Benner, Axel
%A Hadaschik, Boris
%A Giesel, Frederik
%A Kristiansen, Glen
%A Antoch, Gerald
%A Becker, Nikolaus
%A Kaaks, Rudolf
%A Albers, Peter
%A Schimmöller, Lars
%T Value of Additional Systematic Cores During Magnetic Resonance Imaging-guided Targeted Biopsy in Prostate Cancer Screening for Young Men: Results from the PROBASE Trial.
%J European urology oncology
%V nn
%@ 2588-9311
%C Amsterdam
%I Elsevier
%M DKFZ-2025-02369
%P nn
%D 2025
%Z #EA:C130#LA:C130# / epub
%X While magnetic resonance imaging (MRI)-guided targeted biopsy (TBx) is becoming an integral part of early detection of prostate cancer (PC), its role in screening of younger men remains unclear. We analyzed the additional value of systematic biopsy (SBx) in improving detection of clinically significant PC (csPC).A total of 525 men aged 45-54 yr with confirmed prostate-specific antigen ≥3.0 ng/ml underwent multiparametric MRI followed by combined TBx and SBx between February 2014 and August 2023 within a multicenter prospective screening trial in Germany. Software-based MRI/ultrasound fusion TBx (2 cores per lesion) combined with SBx was performed via a transrectal or transperineal approach. The primary objective was to analyze differences in csPC detection rates between SBx and TBx in relation to MRI. Secondary objectives were detection rates by International Society of Urological Pathology grade group (GG) and the distribution of SBx and/or TBx findings.PC was detected in 209 men (39
%K Fusion biopsy (Other)
%K Magnetic resonance imaging (Other)
%K Prostate cancer (Other)
%K Prostate-specific antigen (Other)
%K Risk-adapted screening (Other)
%K Ultrasound (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:41219113
%R 10.1016/j.euo.2025.10.014
%U https://inrepo02.dkfz.de/record/305749