TY  - JOUR
AU  - Guberina, Maja
AU  - Metzenmacher, Martin
AU  - Pöttgen, Christoph
AU  - Wiesweg, Marcel
AU  - Guberina, Nika
AU  - Merkel-Jens, Anja
AU  - Lütke-Brintrup, Diana
AU  - Bölükbas, Servet
AU  - Eberhardt, Wilfried E E
AU  - Stamatis, Georgios
AU  - Doerr, Fabian
AU  - Plönes, Till
AU  - Hoffmann, Christian
AU  - Zaun, Gregor
AU  - Höing, Benedikt
AU  - Kürten, Cornelius
AU  - Mladenov, Emil
AU  - Iliakis, George
AU  - Kersting, David
AU  - Fendler, Wolfgang P
AU  - Gauler, Thomas
AU  - Opitz, Marcel
AU  - Milosevic, Aleksandar
AU  - Forsting, Michael
AU  - Nensa, Felix
AU  - Umutlu, Lale
AU  - Funke, Faustina
AU  - Hautzel, Hubertus
AU  - Herrmann, Ken
AU  - Taube, Christian
AU  - Theegarten, Dirk
AU  - Aigner, Clemens
AU  - Schuler, Martin
AU  - Stuschke, Martin
TI  - Pathologic Complete Response Predicts Long-Term Survival Following Neoadjuvant Induction Chemotherapy and Chemo-Radiotherapy in Stage-III Non-Small Cell Lung Cancer.
JO  - Thoracic cancer
VL  - 16
IS  - 22
SN  - 1759-7706
CY  - Hoboken, NJ ˜[u.a.]œ
PB  - Wiley-Blackwell
M1  - DKFZ-2025-02569
SP  - e70183
PY  - 2025
AB  - To analyze the association of pathologic-complete-response (PCR) and survival after neoadjuvant concurrent chemo-radiotherapy, we evaluated a large cohort of patients with potentially resectable stage IIIA-IIIC non-small cell lung cancer (NSCLC) treated with a trimodality approach.Consecutive patients underwent neoadjuvant induction chemotherapy, followed by concurrent chemo-radiotherapy and surgery. Patients received established imaging, and diagnostics. Leave-one-out cross-validation was employed to identify the most effective prognostic classifier.Altogether, 403 patients treated between 06/2000 and 01/2020 were included. Median follow-up was 111 months (IQR: 71-127 months). PCR was achieved in 34
KW  - Humans
KW  - Carcinoma, Non-Small-Cell Lung: pathology
KW  - Carcinoma, Non-Small-Cell Lung: mortality
KW  - Carcinoma, Non-Small-Cell Lung: therapy
KW  - Carcinoma, Non-Small-Cell Lung: drug therapy
KW  - Male
KW  - Female
KW  - Neoadjuvant Therapy: methods
KW  - Neoadjuvant Therapy: mortality
KW  - Lung Neoplasms: pathology
KW  - Lung Neoplasms: mortality
KW  - Lung Neoplasms: therapy
KW  - Lung Neoplasms: drug therapy
KW  - Induction Chemotherapy: methods
KW  - Middle Aged
KW  - Aged
KW  - Neoplasm Staging
KW  - Prognosis
KW  - Chemoradiotherapy: methods
KW  - Pathologic Complete Response
KW  - induction chemo‐radiotherapy (Other)
KW  - major pathological response (Other)
KW  - pathologic complete response (Other)
KW  - potentially resectable stage III NSCLC (Other)
KW  - predictor of survival (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:41261778
DO  - DOI:10.1111/1759-7714.70183
UR  - https://inrepo02.dkfz.de/record/306357
ER  -