%0 Journal Article
%A Bartel, Timo
%A Pabst, Kim M
%A Barg, Christina
%A Berliner, Christoph A
%A Hamacher, Rainer
%A Bauer, Sebastian
%A Falkenhorst, Johanna
%A Kessler, Lukas
%A Nader, Michael
%A Barbato, Francesco
%A Siveke, Jens
%A Herrmann, Ken
%A Fendler, Wolfgang P
%T [68Ga]Ga-FAPI-46 PET/CT of Patients with Gastrointestinal Stromal Tumors in Comparison to 2-[18F]FDG PET/CT and Contrast-Enhanced CT: Results from a Prospective Observational Study.
%J Journal of nuclear medicine
%V nn
%@ 0097-9058
%C New York, NY
%I Soc.
%M DKFZ-2025-02571
%P nn
%D 2025
%Z epub
%X Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract. Although contrast-enhanced CT (ceCT) and 2-[18F]FDG PET/CT remain standard imaging modalities, both exhibit limitations in detecting small peritoneal metastases and tumors with low metabolic activity. 68Ga-labeled fibroblast activation protein inhibitors (FAPIs) have shown promising results in various malignancies; however, comparative data on GISTs are limited. This study aimed to assess the diagnostic performance of [68Ga]Ga-FAPI-46 PET/CT in comparison with 2-[18F]FDG PET/CT and ceCT, including evaluation of interreader reproducibility and clinical impact. Methods: This study retrospectively reviewed 25 patients with histopathologically confirmed GISTs undergoing [68Ga]Ga-FAPI-46 PET/CT as part of a prospective observational study (NCT04571086). All patients (n = 25) underwent additional clinical 2-[18F]FDG PET/CT; ceCT was performed for 23 of 25 patients. Imaging was assessed per patient and per region (primary tumor, lymph nodes, and visceral and bone metastases), and a composite reference standard that included histopathology, follow-up imaging, and clinical data was applied. Interreader agreement, stratified by experience level, was analyzed using Cohen κ (κCohen). Referring physicians completed questionnaires before and after imaging to determine clinical impact. Results: In total, 28 validated regions (n = 20 patients) were included in the diagnostic efficacy analysis. Per region, ceCT and [68Ga]Ga-FAPI-46 PET/CT demonstrated comparable sensitivity (83
%K 2-[18F]FDG PET/CT (Other)
%K GIST (Other)
%K [68Ga]Ga-FAPI-46 PET/CT (Other)
%K detection efficacy (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:41266252
%R 10.2967/jnumed.125.270850
%U https://inrepo02.dkfz.de/record/306359