%0 Journal Article
%A Adelabu, Isaiah
%A Gyesi, Joseph
%A Chowdhury, Md Raduanul H
%A Oladun, Clementinah
%A Nantogma, Shiraz
%A Foren, Grant
%A Samoilenko, Anna
%A Ettedgui, Jessica
%A Swenson, Rolf E
%A Krishna, Murali C
%A TomHon, Patrick
%A Theis, Thomas
%A de Maissin, Henri
%A Schmidt, Andreas
%A Goodson, Boyd M
%A Scofield, Sydney
%A Stilgenbauer, Lukas
%A Sadagurski, Marianna
%A Chekmenev, Eduard Y
%T Multidimensional pH-Temperature Mapping of SABRE-SHEATH 13C Hyperpolarization of [1-13C]Pyruvate.
%J The journal of physical chemistry / B
%V nn
%@ 1520-6106
%C Washington, DC
%I Americal Chemical Society
%M DKFZ-2025-02582
%P nn
%D 2025
%Z epub
%X Hyperpolarized [1-13C]pyruvate has emerged as a next-generation molecular probe for in vivo metabolic flux imaging in deep tissue. This molecular contrast agent is now under evaluation in over 50 clinical trials, according to clinicaltrials.gov. Hyperpolarized [1-13C]pyruvate is produced through dissolution dynamic nuclear polarization (d-DNP) for clinical research use. This remarkable hyperpolarization technique is regarded as expensive (>2 M equipment cost) and slow (1 h production). One alternative hyperpolarization technique called Signal Amplification By Reversible Exchange (SABRE) in SHield Enables Alignment Transfer to Heteronuclei (SABRE-SHEATH) has recently garnered substantial attention for production of hyperpolarized [1-13C]pyruvate quickly (in 1 min) and inexpensively (<
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:41273337
%R 10.1021/acs.jpcb.5c05015
%U https://inrepo02.dkfz.de/record/306517