TY - JOUR
AU - Adelabu, Isaiah
AU - Gyesi, Joseph
AU - Chowdhury, Md Raduanul H
AU - Oladun, Clementinah
AU - Nantogma, Shiraz
AU - Foren, Grant
AU - Samoilenko, Anna
AU - Ettedgui, Jessica
AU - Swenson, Rolf E
AU - Krishna, Murali C
AU - TomHon, Patrick
AU - Theis, Thomas
AU - de Maissin, Henri
AU - Schmidt, Andreas
AU - Goodson, Boyd M
AU - Scofield, Sydney
AU - Stilgenbauer, Lukas
AU - Sadagurski, Marianna
AU - Chekmenev, Eduard Y
TI - Multidimensional pH-Temperature Mapping of SABRE-SHEATH 13C Hyperpolarization of [1-13C]Pyruvate.
JO - The journal of physical chemistry / B
VL - nn
SN - 1520-6106
CY - Washington, DC
PB - Americal Chemical Society
M1 - DKFZ-2025-02582
SP - nn
PY - 2025
N1 - epub
AB - Hyperpolarized [1-13C]pyruvate has emerged as a next-generation molecular probe for in vivo metabolic flux imaging in deep tissue. This molecular contrast agent is now under evaluation in over 50 clinical trials, according to clinicaltrials.gov. Hyperpolarized [1-13C]pyruvate is produced through dissolution dynamic nuclear polarization (d-DNP) for clinical research use. This remarkable hyperpolarization technique is regarded as expensive (>2 M equipment cost) and slow (1 h production). One alternative hyperpolarization technique called Signal Amplification By Reversible Exchange (SABRE) in SHield Enables Alignment Transfer to Heteronuclei (SABRE-SHEATH) has recently garnered substantial attention for production of hyperpolarized [1-13C]pyruvate quickly (in 1 min) and inexpensively (<
LB - PUB:(DE-HGF)16
C6 - pmid:41273337
DO - DOI:10.1021/acs.jpcb.5c05015
UR - https://inrepo02.dkfz.de/record/306517
ER -