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| Home > Publications database > Multidimensional pH-Temperature Mapping of SABRE-SHEATH 13C Hyperpolarization of [1-13C]Pyruvate. > print |
| 001 | 306517 | ||
| 005 | 20251212125553.0 | ||
| 024 | 7 | _ | |a 10.1021/acs.jpcb.5c05015 |2 doi |
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| 041 | _ | _ | |a English |
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| 100 | 1 | _ | |a Adelabu, Isaiah |0 0000-0002-9475-0851 |b 0 |
| 245 | _ | _ | |a Multidimensional pH-Temperature Mapping of SABRE-SHEATH 13C Hyperpolarization of [1-13C]Pyruvate. |
| 260 | _ | _ | |a Washington, DC |c 2025 |b Americal Chemical Society |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1765540520_396855 |2 PUB:(DE-HGF) |
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| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 500 | _ | _ | |a J. Phys. Chem. B 2025, 129, 12401−12409 |
| 520 | _ | _ | |a Hyperpolarized [1-13C]pyruvate has emerged as a next-generation molecular probe for in vivo metabolic flux imaging in deep tissue. This molecular contrast agent is now under evaluation in over 50 clinical trials, according to clinicaltrials.gov. Hyperpolarized [1-13C]pyruvate is produced through dissolution dynamic nuclear polarization (d-DNP) for clinical research use. This remarkable hyperpolarization technique is regarded as expensive (>2 M equipment cost) and slow (1 h production). One alternative hyperpolarization technique called Signal Amplification By Reversible Exchange (SABRE) in SHield Enables Alignment Transfer to Heteronuclei (SABRE-SHEATH) has recently garnered substantial attention for production of hyperpolarized [1-13C]pyruvate quickly (in 1 min) and inexpensively (<$20K equipment). It has been successfully demonstrated in vivo for metabolic imaging of cancer. This technique relies on the simultaneous chemical exchange of parahydrogen, acting as a source of nuclear spin order, and [1-13C]pyruvate on a Ir-IMes polarization transfer catalyst at ∼0.4 μm magnetic field. The SABRE catalyst forms two kinds of complexes with parahydrogen-derived hydrides, pyruvate, and dimethyl sulfoxide, acting as a critically important coligand; however, only the complex that binds pyruvate in an equatorial position can release hyperpolarized [1-13C]pyruvate into the solution to enable bulk HP [1-13C]pyruvate production for use in molecular imaging and other applications. Here, we investigate the interplay of pH and temperature with the SABRE-SHEATH hyperpolarization of [1-13C]pyruvate. Temperature and pH modulate this process in remarkable and complementary ways, greatly affecting pyruvate exchange and 13C relaxation dynamics. The overall process is optimal at pH (methanol) of 6.5-7.7 and a temperature of 6 °C: indeed, the catalyst-bound pyruvate exhibits high 13C polarization levels in excess of 25%. The 13C polarization results are additionally supported by 13C relaxation dynamics at a polarization field of 0.4 microtesla. These results provide deeper understanding of the SABRE-SHEATH process and pave the way to further improve the efficiency of the hyperpolarization technique. |
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| 700 | 1 | _ | |a Gyesi, Joseph |b 1 |
| 700 | 1 | _ | |a Chowdhury, Md Raduanul H |b 2 |
| 700 | 1 | _ | |a Oladun, Clementinah |b 3 |
| 700 | 1 | _ | |a Nantogma, Shiraz |b 4 |
| 700 | 1 | _ | |a Foren, Grant |b 5 |
| 700 | 1 | _ | |a Samoilenko, Anna |b 6 |
| 700 | 1 | _ | |a Ettedgui, Jessica |0 0000-0003-4903-1724 |b 7 |
| 700 | 1 | _ | |a Swenson, Rolf E |b 8 |
| 700 | 1 | _ | |a Krishna, Murali C |b 9 |
| 700 | 1 | _ | |a TomHon, Patrick |0 0000-0003-3202-9812 |b 10 |
| 700 | 1 | _ | |a Theis, Thomas |0 0000-0001-6779-9978 |b 11 |
| 700 | 1 | _ | |a de Maissin, Henri |b 12 |
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| 700 | 1 | _ | |a Goodson, Boyd M |0 0000-0001-6079-5077 |b 14 |
| 700 | 1 | _ | |a Scofield, Sydney |b 15 |
| 700 | 1 | _ | |a Stilgenbauer, Lukas |b 16 |
| 700 | 1 | _ | |a Sadagurski, Marianna |b 17 |
| 700 | 1 | _ | |a Chekmenev, Eduard Y |0 0000-0002-8745-8801 |b 18 |
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