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@ARTICLE{Roohani:306534,
      author       = {S. Roohani$^*$ and P. W. M. Chung and B. C. Dickson and P.
                      C. Ferguson and A. M. Griffin and D. G. Kirsch and R. Krcek
                      and B. O'Sullivan and D. B. Shultz and K. M. Tsoi and P.
                      Wong and J. S. Wunder and C. N. Catton},
      title        = {{R}efining surveillance in {M}yxoid liposarcoma: long-term
                      recurrence patterns and functional outcomes after surgery ±
                      radiotherapy in 186 patients.},
      journal      = {Radiotherapy and oncology},
      volume       = {214},
      issn         = {0167-8140},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DKFZ-2025-02599},
      pages        = {111275},
      year         = {2026},
      note         = {Volume 214, January 2026, 111275},
      abstract     = {To assess oncologic, functional outcomes, and recurrence
                      patterns in a large cohort of prospectively collected
                      patients with localized extremity/trunk myxoid liposarcoma
                      with long-term follow-up.Analysis of 186 patients
                      (1992-2025) treated with surgery ± perioperative
                      radiotherapy. Data were drawn from prospective institutional
                      registries with central pathology/radiology review.wound
                      complications, late toxicity, functional scores, overall
                      survival (OS), cancer-specific survival (CSS), and local
                      (LR) and distant metastatic recurrence (DM).Median age was
                      44.5 years; median follow-up 77 months. All had surgery;
                      86.6 $\%$ received radiotherapy (73.7 $\%$ preoperatively).
                      Wound complications occurred in 33.3 $\%.$ Late ≥ Grade 2
                      toxicities: skin (7.5 $\%),$ subcutaneous fibrosis (14.5
                      $\%),$ joint stiffness (2.2 $\%),$ edema (9.1 $\%).$
                      Functional scores at last follow-up: median TESS: 97 (mean
                      91.3), MSTS-87: 35 (mean 33.1), MSTS-93: 100 (mean 94.7).
                      LR: 3 cases (1.6 $\%,$ 5-year cumulative incidence: 1.4
                      $\%).$ DM: 31 patients (16.7 $\%),$ involving 40 sites (42.5
                      $\%$ soft tissue, 22.5 $\%$ lung, 17.5 $\%$ bone, 7.5 $\%$
                      liver, 5 $\%$ lymph nodes). Cumulative incidence of DM:
                      1-year 0.6 $\%,$ 5-year 10.8 $\%,$ 10-year 23.4 $\%.$ CSS
                      was 100 $\%,$ 96.4 $\%,$ and 80 $\%$ at 1, 5, and 10 years,
                      respectively. OS was 98.8 $\%,$ 92 $\%,$ and 74.2 $\%$ at
                      the same time points.Local control was high, and long-term
                      function were favorable. Distant recurrences were more
                      frequent, occurred at a constant rate beyond 5 years,
                      without plateau, often involved extra-pulmonary sites, and
                      drove late cancer-related mortality. These findings support
                      the consideration of continued annual follow-up through at
                      least 10 years, with imaging of pulmonary and
                      extra-pulmonary sites to adequately capture the full
                      spectrum of metastatic risk.},
      keywords     = {Cohort study (Other) / Distant failure (Other) /
                      Extremities (Other) / MSTS (Other) / RTOG (Other) / Soft
                      tissue sarcoma (Other) / TESS (Other) / Toxicity (Other) /
                      Trunk wall (Other)},
      cin          = {BE01},
      ddc          = {610},
      cid          = {I:(DE-He78)BE01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41275974},
      doi          = {10.1016/j.radonc.2025.111275},
      url          = {https://inrepo02.dkfz.de/record/306534},
}