%0 Journal Article
%A Gwenzi, Tafirenyika
%A Wankhede, Durgesh
%A Yuan, Tanwei
%A Bhardwaj, Megha
%A Schrotz-King, Petra
%A Anker, Sophie C
%A Schöttker, Ben
%A Hoffmeister, Michael
%A Brenner, Hermann
%T Predicting colorectal cancer survival by combined c-reactive protein and tumor immune score.
%J npj precision oncology
%V nn
%@ 2397-768X
%C [London]
%I Springer Nature
%M DKFZ-2025-02620
%P nn
%D 2025
%Z #EA:C070#LA:C070# / epub
%X We evaluated the joint relationship of post-operative C-reactive protein (poCRP) and a tumor immune-cell-score (IS) with overall survival (OS) and CRC-specific survival (CSS) in 680 colorectal cancer (CRC) patients recruited in Germany. CRP was assessed post-surgery while IS was derived from CD3 + /CD8+ cell densities in tumor tissue. Patients were categorized into four C-Reactive protein-Immune cell Score (CRIS) groups: CRIS-1 (CRP-low/IS-high), CRIS-2 (CRP-low/IS-low), CRIS-3 (CRP-high/IS-high), and CRIS-4 (CRP-high/IS-low). Associations of CRIS with survival were assessed using Cox regression, and quantified by hazard ratios with 95
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:41291131
%R 10.1038/s41698-025-01192-1
%U https://inrepo02.dkfz.de/record/306579