TY  - JOUR
AU  - Gwenzi, Tafirenyika
AU  - Wankhede, Durgesh
AU  - Yuan, Tanwei
AU  - Bhardwaj, Megha
AU  - Schrotz-King, Petra
AU  - Anker, Sophie C
AU  - Schöttker, Ben
AU  - Hoffmeister, Michael
AU  - Brenner, Hermann
TI  - Predicting colorectal cancer survival by combined c-reactive protein and tumor immune score.
JO  - npj precision oncology
VL  - nn
SN  - 2397-768X
CY  - [London]
PB  - Springer Nature
M1  - DKFZ-2025-02620
SP  - nn
PY  - 2025
N1  - #EA:C070#LA:C070# / epub
AB  - We evaluated the joint relationship of post-operative C-reactive protein (poCRP) and a tumor immune-cell-score (IS) with overall survival (OS) and CRC-specific survival (CSS) in 680 colorectal cancer (CRC) patients recruited in Germany. CRP was assessed post-surgery while IS was derived from CD3 + /CD8+ cell densities in tumor tissue. Patients were categorized into four C-Reactive protein-Immune cell Score (CRIS) groups: CRIS-1 (CRP-low/IS-high), CRIS-2 (CRP-low/IS-low), CRIS-3 (CRP-high/IS-high), and CRIS-4 (CRP-high/IS-low). Associations of CRIS with survival were assessed using Cox regression, and quantified by hazard ratios with 95
LB  - PUB:(DE-HGF)16
C6  - pmid:41291131
DO  - DOI:10.1038/s41698-025-01192-1
UR  - https://inrepo02.dkfz.de/record/306579
ER  -