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@ARTICLE{Turcas:306582,
      author       = {A. Turcas and R. Bodensohn$^*$ and E. Clerici and I.
                      Desideri and F. Ehret$^*$ and N. Gleim and H. Maciej and P.
                      Navarria and A. Williamson and J. Wilmann and N. Andratschke
                      and G. Minniti and M. Niyazi$^*$},
      title        = {{P}atterns of care in primary brain tumour {R}eirradiation:
                      {A} survey by the {ESTRO} {CNS} focus {G}roup.},
      journal      = {Radiotherapy and oncology},
      volume       = {nn},
      issn         = {0167-8140},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DKFZ-2025-02623},
      pages        = {nn},
      year         = {2025},
      note         = {epub},
      abstract     = {Reirradiation is increasingly considered for patients with
                      recurrent primary brain tumours, yet clinical practices vary
                      significantly due to limited evidence and a lack of
                      standardized guidelines. This survey aimed to map European
                      practice patterns in brain tumour reirradiation.A 23-item
                      web-based survey was developed by the ESTRO CNS Focus Group
                      to assess institutional characteristics, clinical
                      decision-making, and technical aspects of reirradiation.
                      Distributed via email and social media, the survey collected
                      responses between June-July 2025. Descriptive statistics
                      were applied.Eighty responses from 28 European countries
                      were analysed. High-grade gliomas were the most frequently
                      reirradiated tumours (>80 $\%),$ followed by meningioma (56
                      $\%,$ low-grade glioma (49 $\%),$ and ependymoma (44 $\%).$
                      Conventional photon radiotherapy (RT) was the predominant
                      technique across all tumour types, with varying use of
                      hypofractionation, stereotactic RT, and proton therapy.
                      Target volume definition and margin size varied by
                      histology, with larger margins and inclusion of
                      edema/cavities more frequent in gliomas. MRI-CT fusion was
                      standard for planning. Concurrent systemic treatment was
                      used mainly in high-grade gliomas. Organ at risk dose
                      recovery and cumulative constraints were commonly
                      considered, but threshold values and recovery models
                      differed. Main barriers included fear of toxicities,
                      including radiation necrosis and limited evidence.This
                      survey reveals high heterogeneity in brain tumour
                      reirradiation practices across Europe, especially regarding
                      dose, technique, and target definition. Despite shared
                      principles, consensus is lacking for rarer tumour types.
                      These findings underscore the need for harmonized guidelines
                      and prospective data to optimize patient care.},
      cin          = {TU01 / BE01},
      ddc          = {610},
      cid          = {I:(DE-He78)TU01-20160331 / I:(DE-He78)BE01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41290090},
      doi          = {10.1016/j.radonc.2025.111299},
      url          = {https://inrepo02.dkfz.de/record/306582},
}