%0 Journal Article
%A Le Rhun, Emilie
%A Sain, Debaleena
%A Erridge, Sara C
%A Reardon, David A
%A Minniti, Giuseppe
%A Roth, Patrick
%A Wick, Wolfgang
%A Nabors, Burt
%A Sampson, John
%A Mason, Warren
%A Cloughesy, Tim
%A Reijneveld, Jacob C
%A Stupp, Roger
%A Preusser, Matthias
%A Gorlia, Thierry
%A Weller, Michael
%T Proton Pump Inhibitor Use and Survival in Patients With Newly Diagnosed Glioblastoma.
%J JAMA network open
%V 8
%N 11
%@ 2574-3805
%C Chicago, Ill.
%I American Medical Association
%M DKFZ-2025-02624
%P e2545578 -
%D 2025
%X Proton pump inhibitors (PPI) are often prescribed to prevent steroid-induced gastritis and peptic ulcer disease in patients with glioblastoma. Yet, these drugs may enhance the activity of aldehyde dehydrogenase 1 A1 (ALDH1A1), which has been linked to protection from oxidative stress, radiotherapy, and chemotherapy.To explore the associations of the use of potent ALDH1A1-activating PPIs (PA-PPIs) and other antacid drugs with outcomes in patients with newly diagnosed glioblastoma.This meta-analysis was a secondary analysis of individual prospectively captured patient data using a dataset of 5 randomized clinical trials conducted between 2008 and 2020. Participants included patients with a new diagnosis of glioblastoma. Data analysis was completed in November 2024.We assessed drug use at baseline and defined 3 landmarks: start of temozolomide maintenance cycles 1 (landmark 1) and 4 (landmark 2), and end of cycle 6 (landmark 3).The primary outcome measures were progression-free survival (PFS) and overall survival (OS) from baseline and from the start of each corresponding landmark time.The study population included 2981 patients (1858 [62.3
%K Humans
%K Glioblastoma: mortality
%K Glioblastoma: drug therapy
%K Proton Pump Inhibitors: therapeutic use
%K Male
%K Female
%K Middle Aged
%K Aged
%K Adult
%K Brain Neoplasms: mortality
%K Brain Neoplasms: drug therapy
%K Temozolomide: therapeutic use
%K Proton Pump Inhibitors (NLM Chemicals)
%K Temozolomide (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:41288972
%R 10.1001/jamanetworkopen.2025.45578
%U https://inrepo02.dkfz.de/record/306583