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@ARTICLE{Haselmann:306611,
      author       = {J. Haselmann and S. Roohani$^*$ and D. Wasilewski$^*$ and
                      J. Onken$^*$ and D. Capper$^*$ and D. Kaul$^*$ and F.
                      Ehret$^*$},
      title        = {{T}he interdisciplinary management of craniopharyngioma -
                      practice patterns, outcomes, and insights.},
      journal      = {BMC cancer},
      volume       = {25},
      number       = {1},
      issn         = {1471-2407},
      address      = {London},
      publisher    = {BioMed Central},
      reportid     = {DKFZ-2025-02648},
      pages        = {1837},
      year         = {2025},
      note         = {2025 Nov 28;25(1):1837},
      abstract     = {Craniopharyngiomas are rare, mostly benign brain tumors,
                      and their management remains challenging due to the limited
                      data from large cohorts. This study evaluates the practice
                      patterns and outcomes for craniopharyngioma patients managed
                      at a tertiary care center.This retrospective cohort study
                      included patients with histologically confirmed
                      craniopharyngioma treated between 1996 and 2022. Patient,
                      tumor, and treatment variables were analyzed for their
                      association with local control (LC), progression-free
                      survival (PFS), and overall survival (OS) using
                      multivariable Cox regression models.A total of 88 patients
                      were analyzed. The median clinical and radiographic
                      follow-up periods were 62.0 and 42.5 months, respectively.
                      Fifty-three recurrences and twelve deaths were observed.
                      After primary treatment, the 2-, 4, and 6-year LC and PFS
                      rates were 69.1, 50.7, $37.7\%$ and 71.5, 55.4, and
                      $47.3\%,$ respectively. For patients undergoing primary
                      treatment, multivariable Cox regression showed an
                      association between the extent of resection, i.e., gross
                      total resection (GTR), and PFS (hazard ratio (HR): 0.36, p =
                      0.01) with weaker evidence for LC (HR: 0.40, p = 0.053). Age
                      was the only variable associated with OS (HR: 1.05, p =
                      0.01). Seventeen patients received radiotherapy, which was
                      not formally associated with LC, PFS, and OS. The majority
                      of patients required hormone replacement therapy after
                      treatment.This study underlines the role of GTR in delaying
                      disease progression and the need for hormone replacement
                      after treatment. While radiotherapy was not formally
                      associated with any benefit in this series, its use might be
                      helpful in candidates after subtotal resection and for
                      treating recurrences. Further prospective research is needed
                      to refine treatment algorithms, improve long-term outcomes,
                      and optimize the quality of life of affected patients.},
      keywords     = {Craniopharyngioma (Other) / Hypothalamus (Other) /
                      Neurocognitive deficits (Other) / Neurosurgery (Other) /
                      Pediatrics (Other) / Pituitary gland (Other) / Quality of
                      life (Other) / Radiation therapy (Other) / Radiotherapy
                      (Other) / Reirradiation (Other) / Stereotactic radiosurgery
                      (Other)},
      cin          = {BE01},
      ddc          = {610},
      cid          = {I:(DE-He78)BE01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41310495},
      doi          = {10.1186/s12885-025-14991-3},
      url          = {https://inrepo02.dkfz.de/record/306611},
}