%0 Journal Article
%A Tigu, Adrian-Bogdan
%A Nistor, Madalina
%A Gulei, Diana
%A Constantinescu, Catalin-Sorin
%A Kegyes, David
%A Cenariu, Diana
%A Muresan, Ximena
%A Munteanu, Raluca
%A Feder, Richard
%A Jitaru, Ciprian
%A Bancos, Anamaria
%A Santa, Maria
%A Tomai, Radu
%A Damian, Marc
%A Ivancuta, Andrei
%A Rus, Ioana
%A Bojan, Anca
%A Zdrenghea, Mihnea
%A Buzoianu, Anca-Dana
%A Tanase, Alina
%A Einsele, Hermann
%A Kobold, Sebastian
%A Tomuleasa, Ciprian
%T CARing about autoimmune disorders. Use of chimeric antigen receptor engineered T-cells in autoimmune diseases.
%J Blood reviews
%V nn
%@ 0268-960X
%C Burlington, Mass.
%I Harcourt
%M DKFZ-2025-02662
%P nn
%D 2025
%Z epub
%X Chimeric Antigen Receptor (CAR) T cell therapy, initially developed for hematologic malignancies, has recently emerged as a promising modality for treating autoimmune diseases. This review explores the evolving role of CAR T cells in reprogramming immune tolerance and achieving durable remission in autoimmune disorders. By engineering T cells to target pathogenic B cells or autoreactive T cells, CAR T therapy offers a targeted and potentially curative approach for diseases such as systemic lupus erythematosus, multiple sclerosis, and type 1 diabetes. Early clinical trials and preclinical models have demonstrated the feasibility, safety, and efficacy of CD19-targeted CAR T cells in depleting autoreactive B cells and restoring immune homeostasis. Furthermore, next-generation CAR designs-including regulatory T cell-based CARs and antigen-specific constructs-highlight the growing precision and versatility of this platform. Despite these advances, challenges remain, including potential toxicity, antigen escape, and the need for long-term immune monitoring. This review summarizes current findings, delineates mechanistic insights, and discusses future directions for optimizing CAR T cell therapies in the context of autoimmunity.
%K Autoimmune diseases (Other)
%K CAR T cells (Other)
%K Emerging therapies (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:41318274
%R 10.1016/j.blre.2025.101354
%U https://inrepo02.dkfz.de/record/306669