%0 Journal Article
%A Fuchs, Frederik
%A Herrera, Roberto
%A Kotecha, Rupesh
%A Rubens, Muni
%A Roy, Mukesh
%A Mittauer, Kathryn E
%A Mansoorian, Sina
%A Kaiser, Adeel
%A Kalman, Noah
%A Gaasch, Aurelie
%A Marschner, Sebastian N
%A Bassiri, Nema
%A Rogowski, Paul
%A Eze, Chukwuka
%A Belka, Claus
%A Corradini, Stefanie
%A Chuong, Michael D
%T Multi-Institutional Analysis of MR-Guided Single-Fraction Stereotactic Ablative Body Radiation Therapy: Feasibility, Safety, and Efficacy.
%J International journal of radiation oncology, biology, physics
%V nn
%@ 0360-3016
%C Amsterdam [u.a.]
%I Elsevier Science
%M DKFZ-2025-03029
%P nn
%D 2025
%Z epub / Autoren checken
%X Stereotactic ablative body radiation therapy (SABR) is commonly delivered in multiple fractions, whereas single-fraction (SF) SABR remains uncommon. Magnetic resonance (MR) guided linacs provide superior soft-tissue contrast compared to cone-beam computed tomography on conventional linacs, online adaptive replanning, continuous intrafraction visualization, and automatically triggered beam delivery, potentially enabling safe and effective SF-SABR.We retrospectively analyzed patients treated with MR-guided SF-SABR on a 0.35 Tesla MR-linac at two centers in XXX and XXX (anonymized for review). Median SF-SABR doses were 28 Gy (range: 28-40 Gy) for liver lesions, 30 Gy (range: 28-34 Gy) for lung lesions, 25 Gy for adrenal gland lesions and lymph nodes, and 26 Gy (range: 25-26 Gy) for renal lesions. Endpoints included local control (LC), progression-free survival (PFS), overall survival (OS), and toxicity graded according to CTCAE v5.0.Between April 2020 and December 2024, 161 patients with 175 lesions underwent MR-guided SF-SABR. Lesion distribution was liver (48.0
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:41422918
%R 10.1016/j.ijrobp.2025.12.018
%U https://inrepo02.dkfz.de/record/307385