TY  - JOUR
AU  - Fuchs, Frederik
AU  - Herrera, Roberto
AU  - Kotecha, Rupesh
AU  - Rubens, Muni
AU  - Roy, Mukesh
AU  - Mittauer, Kathryn E
AU  - Mansoorian, Sina
AU  - Kaiser, Adeel
AU  - Kalman, Noah
AU  - Gaasch, Aurelie
AU  - Marschner, Sebastian N
AU  - Bassiri, Nema
AU  - Rogowski, Paul
AU  - Eze, Chukwuka
AU  - Belka, Claus
AU  - Corradini, Stefanie
AU  - Chuong, Michael D
TI  - Multi-Institutional Analysis of MR-Guided Single-Fraction Stereotactic Ablative Body Radiation Therapy: Feasibility, Safety, and Efficacy.
JO  - International journal of radiation oncology, biology, physics
VL  - nn
SN  - 0360-3016
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - DKFZ-2025-03029
SP  - nn
PY  - 2025
N1  - epub / Autoren checken
AB  - Stereotactic ablative body radiation therapy (SABR) is commonly delivered in multiple fractions, whereas single-fraction (SF) SABR remains uncommon. Magnetic resonance (MR) guided linacs provide superior soft-tissue contrast compared to cone-beam computed tomography on conventional linacs, online adaptive replanning, continuous intrafraction visualization, and automatically triggered beam delivery, potentially enabling safe and effective SF-SABR.We retrospectively analyzed patients treated with MR-guided SF-SABR on a 0.35 Tesla MR-linac at two centers in XXX and XXX (anonymized for review). Median SF-SABR doses were 28 Gy (range: 28-40 Gy) for liver lesions, 30 Gy (range: 28-34 Gy) for lung lesions, 25 Gy for adrenal gland lesions and lymph nodes, and 26 Gy (range: 25-26 Gy) for renal lesions. Endpoints included local control (LC), progression-free survival (PFS), overall survival (OS), and toxicity graded according to CTCAE v5.0.Between April 2020 and December 2024, 161 patients with 175 lesions underwent MR-guided SF-SABR. Lesion distribution was liver (48.0
LB  - PUB:(DE-HGF)16
C6  - pmid:41422918
DO  - DOI:10.1016/j.ijrobp.2025.12.018
UR  - https://inrepo02.dkfz.de/record/307385
ER  -