%0 Journal Article
%A Augustin, Teresa
%A Oliinyk, Dmytro
%A Haderlein, Marlen
%A Frei, Charlotte
%A Jacob, Julia
%A Medenwald, Daniel
%A Trommer, Maike
%A Mäurer, Matthias
%A Drozdz, Sonia
%A Rühle, Alexander
%A Grosu, Anca-Ligia
%A Nicolay, Nils Henrik
%A Waltenberger, Maria
%A Combs, Stephanie E
%A Löser, Anastassia
%A Oertel, Michael
%A Eich, Hans Theodor
%A Janssen, Stefan
%A Rauch, Josefine
%A Gurtner, Ralph
%A Renollet, Robert
%A Spitzweg, Christine
%A Vordermark, Dirk
%A Belka, Claus
%A Käsmann, Lukas
%T Impact of comorbidities on treatment management and prognosis in patients with anaplastic thyroid cancer (ATC).
%J Journal of cancer research and clinical oncology
%V 152
%N 1
%@ 0301-1585
%C Heidelberg
%I Springer
%M DKFZ-2025-03040
%P 22
%D 2026
%Z Volume 152, article number 22, (2026) 
%X To evaluate the impact of comorbidities on treatment allocation and prognosis in anaplastic thyroid cancer, 137 patients from 10 German tertiary cancer centers treated with radiotherapy between 2001 and 2020 were analyzed. Four validated comorbidity scores were applied to assess comorbidity burden. The primary objective was to identify prognostic factors for the survival rate at 6 months after radiotherapy and discriminate the comorbidity scores using concordance statistics, ROC curve net reclassification index, and integrated discrimination improvement for 6-month survival. The median overall survival (OS) of the entire cohort was 4 months (95
%K Humans
%K Female
%K Male
%K Thyroid Carcinoma, Anaplastic: therapy
%K Thyroid Carcinoma, Anaplastic: epidemiology
%K Thyroid Carcinoma, Anaplastic: radiotherapy
%K Thyroid Carcinoma, Anaplastic: pathology
%K Thyroid Carcinoma, Anaplastic: mortality
%K Comorbidity
%K Prognosis
%K Middle Aged
%K Aged
%K Thyroid Neoplasms: therapy
%K Thyroid Neoplasms: pathology
%K Thyroid Neoplasms: epidemiology
%K Thyroid Neoplasms: radiotherapy
%K Thyroid Neoplasms: mortality
%K Adult
%K Aged, 80 and over
%K Retrospective Studies
%K Survival Rate
%K ATC (Other)
%K Comorbidity (Other)
%K Prognosis (Other)
%K Real-word data (Other)
%K Treatment allocation (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:41436662
%2 pmc:PMC12728151
%R 10.1007/s00432-025-06403-7
%U https://inrepo02.dkfz.de/record/307441