TY  - JOUR
AU  - Augustin, Teresa
AU  - Oliinyk, Dmytro
AU  - Haderlein, Marlen
AU  - Frei, Charlotte
AU  - Jacob, Julia
AU  - Medenwald, Daniel
AU  - Trommer, Maike
AU  - Mäurer, Matthias
AU  - Drozdz, Sonia
AU  - Rühle, Alexander
AU  - Grosu, Anca-Ligia
AU  - Nicolay, Nils Henrik
AU  - Waltenberger, Maria
AU  - Combs, Stephanie E
AU  - Löser, Anastassia
AU  - Oertel, Michael
AU  - Eich, Hans Theodor
AU  - Janssen, Stefan
AU  - Rauch, Josefine
AU  - Gurtner, Ralph
AU  - Renollet, Robert
AU  - Spitzweg, Christine
AU  - Vordermark, Dirk
AU  - Belka, Claus
AU  - Käsmann, Lukas
TI  - Impact of comorbidities on treatment management and prognosis in patients with anaplastic thyroid cancer (ATC).
JO  - Journal of cancer research and clinical oncology
VL  - 152
IS  - 1
SN  - 0301-1585
CY  - Heidelberg
PB  - Springer
M1  - DKFZ-2025-03040
SP  - 22
PY  - 2026
N1  - Volume 152, article number 22, (2026) 
AB  - To evaluate the impact of comorbidities on treatment allocation and prognosis in anaplastic thyroid cancer, 137 patients from 10 German tertiary cancer centers treated with radiotherapy between 2001 and 2020 were analyzed. Four validated comorbidity scores were applied to assess comorbidity burden. The primary objective was to identify prognostic factors for the survival rate at 6 months after radiotherapy and discriminate the comorbidity scores using concordance statistics, ROC curve net reclassification index, and integrated discrimination improvement for 6-month survival. The median overall survival (OS) of the entire cohort was 4 months (95
KW  - Humans
KW  - Female
KW  - Male
KW  - Thyroid Carcinoma, Anaplastic: therapy
KW  - Thyroid Carcinoma, Anaplastic: epidemiology
KW  - Thyroid Carcinoma, Anaplastic: radiotherapy
KW  - Thyroid Carcinoma, Anaplastic: pathology
KW  - Thyroid Carcinoma, Anaplastic: mortality
KW  - Comorbidity
KW  - Prognosis
KW  - Middle Aged
KW  - Aged
KW  - Thyroid Neoplasms: therapy
KW  - Thyroid Neoplasms: pathology
KW  - Thyroid Neoplasms: epidemiology
KW  - Thyroid Neoplasms: radiotherapy
KW  - Thyroid Neoplasms: mortality
KW  - Adult
KW  - Aged, 80 and over
KW  - Retrospective Studies
KW  - Survival Rate
KW  - ATC (Other)
KW  - Comorbidity (Other)
KW  - Prognosis (Other)
KW  - Real-word data (Other)
KW  - Treatment allocation (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:41436662
C2  - pmc:PMC12728151
DO  - DOI:10.1007/s00432-025-06403-7
UR  - https://inrepo02.dkfz.de/record/307441
ER  -