TY - JOUR AU - Lamanna-Rama, Nicolás AU - Casquero-Veiga, Marta AU - Ceron, Carlos AU - Sobrino, Gorka AU - Fernandez-Nueda, Irene AU - Kossatz, Susanne AU - Sehlin, Dag AU - Desco, Manuel AU - Salinas, Beatriz AU - Cortes-Canteli, Marta TI - Alzheimer's Imaging Consortium. JO - Alzheimer's and dementia VL - 21 Suppl 8 IS - Suppl 8 SN - 1552-5260 CY - Hoboken, NJ PB - Wiley M1 - DKFZ-2025-03047 SP - e109958 PY - 2025 N1 - Poster presentation / PMID: 41434183 AB - Alzheimer's disease (AD) is the most common form of dementia[1]. Despite the advances in the understanding of its main neuropathological hallmarks, a significant gap remains in comprehending this multifactorial neurodegenerative disorder. Contributing factors to AD include chronic vascular dysregulation and a prothrombotic milieu, promoting fibrin accumulation in brain vessels[2]. Fibrin, the main protein component of blood clots, is significantly increased in 60 KW - Humans KW - Alzheimer Disease: diagnostic imaging KW - Alzheimer Disease: metabolism KW - Alzheimer Disease: pathology KW - Animals KW - Fibrin: metabolism KW - Brain: diagnostic imaging KW - Brain: metabolism KW - Brain: pathology KW - Biomarkers KW - Disease Models, Animal KW - Fibrin (NLM Chemicals) KW - Biomarkers (NLM Chemicals) LB - PUB:(DE-HGF)16 C6 - pmid:41434183 C2 - pmc:PMC12726136 DO - DOI:10.1002/alz70862_109958 UR - https://inrepo02.dkfz.de/record/307448 ER -