%0 Journal Article
%A Lazzeroni, Marta
%A Ureba, Ana
%A Schäfer, Henning
%A Nicolay, Nils
%A Rühle, Alexander
%A Baltas, Dimos
%A Dasu, Alexandru
%A Meyer, Philipp T
%A Mix, Michael
%A Toma-Dasu, Iuliana
%A Grosu, Anca L
%T Biologically Individualized Radiotherapy Based on PET: A Novel Approach to Treatment Optimization of Head and Neck Cancer.
%J Journal of nuclear medicine
%V nn
%@ 0097-9058
%C New York, NY
%I Soc.
%M DKFZ-2026-00005
%P nn
%D 2025
%Z epub
%X Current radiotherapy for malignant tumors often adopts a 'one-size-fits-all' approach, prescribing the same irradiation dose for patients with similar clinical indications. However, advancements in functional imaging allow for biologically individualized strategies, with dose distribution tailored to the specific tumor biology. This study proposes a novel approach to biologically individualized radiotherapy, exploiting the synergistic combination of the tumor clonogenic cell information from [18F]FDG PET images and radiosensitivity from [18F]fluoromisonidazole (FMISO) PET images. Methods: Twenty-eight patients with head and neck squamous cell carcinoma (HNSCC) were analyzed. Using imaging biomarkers, individualized tumor profiles were obtained from oxygen partial pressure and clonogenic cell density maps derived from [18F]FMISO and [18F]FDG PET, respectively. Dose-escalated radiotherapy plans aiming at 95
%K biologically individualized radiotherapy (Other)
%K clonogenic cell density (Other)
%K dual-tracer PET (Other)
%K head and neck squamous cell carcinoma (Other)
%K tumor hypoxia (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:41469160
%R 10.2967/jnumed.125.270403
%U https://inrepo02.dkfz.de/record/307500