TY  - JOUR
AU  - Lazzeroni, Marta
AU  - Ureba, Ana
AU  - Schäfer, Henning
AU  - Nicolay, Nils
AU  - Rühle, Alexander
AU  - Baltas, Dimos
AU  - Dasu, Alexandru
AU  - Meyer, Philipp T
AU  - Mix, Michael
AU  - Toma-Dasu, Iuliana
AU  - Grosu, Anca L
TI  - Biologically Individualized Radiotherapy Based on PET: A Novel Approach to Treatment Optimization of Head and Neck Cancer.
JO  - Journal of nuclear medicine
VL  - nn
SN  - 0097-9058
CY  - New York, NY
PB  - Soc.
M1  - DKFZ-2026-00005
SP  - nn
PY  - 2025
N1  - epub
AB  - Current radiotherapy for malignant tumors often adopts a 'one-size-fits-all' approach, prescribing the same irradiation dose for patients with similar clinical indications. However, advancements in functional imaging allow for biologically individualized strategies, with dose distribution tailored to the specific tumor biology. This study proposes a novel approach to biologically individualized radiotherapy, exploiting the synergistic combination of the tumor clonogenic cell information from [18F]FDG PET images and radiosensitivity from [18F]fluoromisonidazole (FMISO) PET images. Methods: Twenty-eight patients with head and neck squamous cell carcinoma (HNSCC) were analyzed. Using imaging biomarkers, individualized tumor profiles were obtained from oxygen partial pressure and clonogenic cell density maps derived from [18F]FMISO and [18F]FDG PET, respectively. Dose-escalated radiotherapy plans aiming at 95
KW  - biologically individualized radiotherapy (Other)
KW  - clonogenic cell density (Other)
KW  - dual-tracer PET (Other)
KW  - head and neck squamous cell carcinoma (Other)
KW  - tumor hypoxia (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:41469160
DO  - DOI:10.2967/jnumed.125.270403
UR  - https://inrepo02.dkfz.de/record/307500
ER  -