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@ARTICLE{Ehret:307520,
      author       = {F. Ehret$^*$ and A. Williamson and T. Kazda and C. Seidel},
      title        = {{T}reating brainstem metastases with stereotactic
                      radiosurgery after whole-brain radiotherapy - {P}recision
                      strike or risky gamble?},
      journal      = {Radiotherapy and oncology},
      volume       = {nn},
      issn         = {0167-8140},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DKFZ-2026-00025},
      pages        = {nn},
      year         = {2025},
      note         = {epub},
      abstract     = {Stereotactic radiosurgery (SRS) for the management of
                      brainstem metastasis.An 81-year-old female with good
                      performance status (Karnofsky performance status $90\%)$ and
                      a history of metastatic small cell lung cancer to the brain,
                      lung, and pleura presents with a new single brainstem
                      metastasis, measuring 1.27 cm in its largest diameter with a
                      volume of 1.52 cm3 (Fig. 1). The tumor was initially staged
                      as cT4 cN3 cM1a, with lung and pleural metastases. She
                      received first-line chemotherapy with carboplatin and
                      etoposide, achieving a good response. Magnetic resonance
                      imaging six months after the last chemotherapy cycle
                      demonstrated three new brain metastases. She subsequently
                      underwent whole-brain radiotherapy (WBRT), receiving a total
                      dose of 35 Gy delivered in 14 fractions. All brain
                      metastases showed a complete response after the treatment.
                      Her current extracranial disease remains stable after
                      first-line chemotherapy. On physical examination, she has no
                      neurological deficits and denies experiencing new headaches,
                      nausea, or any other new complaints. She is not taking
                      steroids. The brainstem metastasis was diagnosed one year
                      after the completion of WBRT.},
      keywords     = {Brain metastasis (Other) / Brainstem metastasis (Other) /
                      Radiosurgery (Other) / Reirradiation (Other) / Stereotactic
                      radiosurgery (Other)},
      cin          = {BE01},
      ddc          = {610},
      cid          = {I:(DE-He78)BE01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41478752},
      doi          = {10.1016/j.radonc.2025.111099},
      url          = {https://inrepo02.dkfz.de/record/307520},
}