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@ARTICLE{Becht:307524,
      author       = {S. Becht and N. Ben Khaled$^*$ and S. Schrodi and M. von
                      Bergwelt-Baildon$^*$ and P. Buggisch and A. Crispin and
                      W.-P. Hofmann and U. Marschall and J. Mayerle and B. Mörtl
                      and S. Orabi and A. Philipp and J. Trojan and T. Weiglein
                      and E. N. De Toni$^*$ and K. Berger-Thürmel$^*$},
      title        = {{W}hat can claims data tell us about risk factors and
                      survival of patients with hepatocellular carcinoma?
                      {I}nsights from a {G}erman population-based study.},
      journal      = {Frontiers in oncology},
      volume       = {15},
      issn         = {2234-943X},
      address      = {Lausanne},
      publisher    = {Frontiers Media},
      reportid     = {DKFZ-2026-00029},
      pages        = {1650982},
      year         = {2025},
      abstract     = {Geographic and temporal variations in the incidence and
                      treatment of chronic viral hepatitis and trends in the
                      development of metabolic and behavioral risk factors result
                      in heterogeneous incidences of hepatocellular carcinoma
                      (HCC). Therefore, national epidemiological information
                      should be evaluated to identify the need for action.This
                      retrospective observational study included adult patients
                      with incident HCC (2016-2020). A network analysis was
                      performed to investigate inter-relationships among risk
                      factor diagnoses before HCC. Kaplan-Meier method and Cox
                      proportional hazard model were used to analyze survival.A
                      total of 2,778 patients were included. Mean age was 71.9
                      years (SD ±9.7); $69\%$ were male. Most frequently
                      documented risk factor diagnoses were diabetes mellitus
                      $(76\%),$ obesity $(56\%),$ liver fibrosis/cirrhosis
                      $(44\%),$ and alcohol abuse $(36\%).$ Hepatitis B and C were
                      documented in $4\%$ and $11\%$ of patients. Behavioral and
                      metabolic risk factors were 1.1-1.9-fold more frequent in
                      men. Diabetes mellitus was the most central risk factor
                      diagnosis co-occurring with other metabolic and behavioral
                      risk factors. Median survival was 8.7 months.In this German
                      cohort, risk factor diagnoses before HCC were
                      multifactorial, with metabolic diseases most frequently
                      co-occurring. Survival after HCC was poor. Controlling
                      metabolic risk factors and surveilling at-risk populations
                      are crucial to mitigating the incidence and improving the
                      survival of HCC patients in Germany. Analyzing claims data
                      enabled efficient and effective generation of
                      epidemiological real-world evidence.},
      keywords     = {cancer epidemiology (Other) / hepatocellular carcinoma
                      (Other) / metabolic risk factors (Other) / real-world
                      evidence (Other) / secondary data (Other)},
      cin          = {MU01},
      ddc          = {610},
      cid          = {I:(DE-He78)MU01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41476582},
      pmc          = {pmc:PMC12750458},
      doi          = {10.3389/fonc.2025.1650982},
      url          = {https://inrepo02.dkfz.de/record/307524},
}