000309946 001__ 309946
000309946 005__ 20260220120944.0
000309946 0247_ $$2doi$$a10.1002/advs.202523198
000309946 0247_ $$2pmid$$apmid:41704007
000309946 037__ $$aDKFZ-2026-00395
000309946 041__ $$aEnglish
000309946 082__ $$a624
000309946 1001_ $$00000-0001-7673-4842$$aSabatier, Marie$$b0
000309946 245__ $$aGPX4 Inhibitor Resistance and Metastatic Features in Triple-Negative Breast Cancer.
000309946 260__ $$aWeinheim$$bWiley-VCH$$c2026
000309946 3367_ $$2DRIVER$$aarticle
000309946 3367_ $$2DataCite$$aOutput Types/Journal article
000309946 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1771511853_3004205
000309946 3367_ $$2BibTeX$$aARTICLE
000309946 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000309946 3367_ $$00$$2EndNote$$aJournal Article
000309946 500__ $$a#DKTKZFB9# / epub
000309946 520__ $$aLeveraging ferroptosis as a cancer therapy has faced challenges due to the limited bioavailability and systemic toxicities of small-molecule ferroptosis modulators. Small molecule inhibitors such as RSL3 and ML210 trigger ferroptosis by targeting glutathione peroxidase 4 (GPX4), a key enzyme that neutralizes lipid peroxides. While many studies have focused on targeting primary tumors, much less is known about the extent to which GPX4-inhibitor resistance may contribute to metastasis. To address this, we cultured triple-negative breast cancer cell lines with GPX4 inhibitors to generate cell lines (M231, 4T1) that were resistant to GPX4 inhibitors (GPX4i). Tumors derived from GPX4i-resistant cells compared to parental cells had unique metabolic and lipidomic profiles, were associated with a shift toward an epithelial-like state (decreased vimentin, increased EpCAM expression), formed decreased spontaneous metastases from primary tumors, but had no differences in overall metastatic burden upon intravenous injection. Collectively, these data demonstrate that long-term maintenance with GPX4-inhibitors in vitro leads to altered metastatic profiles in vivo.
000309946 536__ $$0G:(DE-HGF)POF4-899$$a899 - ohne Topic (POF4-899)$$cPOF4-899$$fPOF IV$$x0
000309946 588__ $$aDataset connected to CrossRef, PubMed, , Journals: inrepo02.dkfz.de
000309946 650_7 $$2Other$$aferroptosis
000309946 650_7 $$2Other$$alipid peroxidation
000309946 650_7 $$2Other$$ametastases
000309946 650_7 $$2Other$$atumor microenvironment
000309946 7001_ $$aKaur, Mayher$$b1
000309946 7001_ $$aChaufan, Milena$$b2
000309946 7001_ $$aHormann, Felix-Levin$$b3
000309946 7001_ $$0P:(DE-HGF)0$$aMelo, Luiza Martins Nascentes$$b4
000309946 7001_ $$aPalma, Mario$$b5
000309946 7001_ $$aTorpey, Jordan$$b6
000309946 7001_ $$aLiang, Yanshan$$b7
000309946 7001_ $$aCarmona, Alanis$$b8
000309946 7001_ $$aFraser, Cameron$$b9
000309946 7001_ $$aFlores, Midori$$b10
000309946 7001_ $$aSzylo, Krystina J$$b11
000309946 7001_ $$aYavari, Mahsa$$b12
000309946 7001_ $$aHui, Sheng$$b13
000309946 7001_ $$0P:(DE-HGF)0$$aTasdogan, Alpaslan$$b14
000309946 7001_ $$aHeiles, Sven$$b15
000309946 7001_ $$00000-0002-7855-9125$$aUbellacker, Jessalyn M$$b16
000309946 773__ $$0PERI:(DE-600)2808093-2$$a10.1002/advs.202523198$$gp. e23198$$pnn$$tAdvanced science$$vnn$$x2198-3844$$y2026
000309946 909CO $$ooai:inrepo02.dkfz.de:309946$$pVDB
000309946 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-HGF)0$$aDeutsches Krebsforschungszentrum$$b4$$kDKFZ
000309946 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-HGF)0$$aDeutsches Krebsforschungszentrum$$b14$$kDKFZ
000309946 9131_ $$0G:(DE-HGF)POF4-899$$1G:(DE-HGF)POF4-890$$2G:(DE-HGF)POF4-800$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bProgrammungebundene Forschung$$lohne Programm$$vohne Topic$$x0
000309946 9141_ $$y2026
000309946 915__ $$0StatID:(DE-HGF)3001$$2StatID$$aDEAL Wiley$$d2025-11-06$$wger
000309946 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bADV SCI : 2022$$d2025-11-06
000309946 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2025-11-06
000309946 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2025-11-06
000309946 915__ $$0StatID:(DE-HGF)0320$$2StatID$$aDBCoverage$$bPubMed Central$$d2025-11-06
000309946 915__ $$0StatID:(DE-HGF)0501$$2StatID$$aDBCoverage$$bDOAJ Seal$$d2024-08-08T17:05:31Z
000309946 915__ $$0StatID:(DE-HGF)0500$$2StatID$$aDBCoverage$$bDOAJ$$d2024-08-08T17:05:31Z
000309946 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bDOAJ : Anonymous peer review$$d2024-08-08T17:05:31Z
000309946 915__ $$0LIC:(DE-HGF)CCBYNV$$2V:(DE-HGF)$$aCreative Commons Attribution CC BY (No Version)$$bDOAJ$$d2024-08-08T17:05:31Z
000309946 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search$$d2025-11-06
000309946 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC$$d2025-11-06
000309946 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2025-11-06
000309946 915__ $$0StatID:(DE-HGF)1150$$2StatID$$aDBCoverage$$bCurrent Contents - Physical, Chemical and Earth Sciences$$d2025-11-06
000309946 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2025-11-06
000309946 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2025-11-06
000309946 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2025-11-06
000309946 915__ $$0StatID:(DE-HGF)9915$$2StatID$$aIF >= 15$$bADV SCI : 2022$$d2025-11-06
000309946 915__ $$0StatID:(DE-HGF)0561$$2StatID$$aArticle Processing Charges$$d2025-11-06
000309946 915__ $$0StatID:(DE-HGF)0700$$2StatID$$aFees$$d2025-11-06
000309946 9201_ $$0I:(DE-He78)ED01-20160331$$kED01$$lDKTK Koordinierungsstelle Essen/Düsseldorf$$x0
000309946 980__ $$ajournal
000309946 980__ $$aVDB
000309946 980__ $$aI:(DE-He78)ED01-20160331
000309946 980__ $$aUNRESTRICTED