Journal Article

DKFZ-2026-01187

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png The MYB-related transcription factor MYPOP acts as a selective regulator of cancer cell growth.

Strunk, J. ; Hüppner, A. ; Sial, M. ; Plath, M. ; Sheriff, M. B. ; Wagner, S. ; Freitag, K. ; Mikuličić, S. ; Döring, T. ; Bopp, T.DKFZ* ; Klein, M. ; Rajalingam, K. ; Harms, G. ; Marini, F. ; Nedwed, A. S. ; Hankeln, T. ; Osterhof, C. ; Schneider, M. A. ; Henrich, A. ; Nubbemeyer, A. ; Suchan, M. ; Brill, S. ; Perkovic, M. ; Schrörs, B. ; Kreiter, S. ; Kölsch, A. ; Diken, M. ; Florin, L.

2026
Springer Nature London

Abstract: The MYB-related transcription factor and partner of profilin (MYPOP or p42POP) is a ubiquitously expressed yet understudied protein recently identified as a restriction factor of oncogenic human papillomaviruses (HPV) and proposed tumor suppressor. Here we show that in HPV-transformed cervical cancer cells, MYPOP induces alterations in cell morphology, silences viral and cellular oncogenes including E6 and MYC, and stimulates the release of the cancer-killing cytokine interleukin-24. Transcriptomic and live-cell analyses reveal a rapid G1/S-phase arrest followed by loss of viable cervical cancer cells and induction of apoptosis. Moreover, MYPOP expression is broadly diminished across multiple human cancers, and its re-expression by both DNA- and mRNA-gene transfer markedly suppresses tumor cell proliferation while sparing normal epidermal keratinocytes. Similarly, murine Mypop inhibits mouse cancer cell growth. Collectively, our findings identify MYPOP as a selective suppressor of tumor cell proliferation across species in vitro and point to its potential relevance for future therapeutic investigation.

Keyword(s): Humans (MeSH) ; Cell Proliferation (MeSH) ; Animals (MeSH) ; Mice (MeSH) ; Female (MeSH) ; Cell Line, Tumor (MeSH) ; Gene Expression Regulation, Neoplastic (MeSH) ; Uterine Cervical Neoplasms: metabolism (MeSH) ; Uterine Cervical Neoplasms: genetics (MeSH) ; Uterine Cervical Neoplasms: pathology (MeSH) ; Uterine Cervical Neoplasms: virology (MeSH) ; Transcription Factors: metabolism (MeSH) ; Transcription Factors: genetics (MeSH) ; Apoptosis (MeSH) ; Transcription Factors

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Contributing Institute(s):

1. DKTK Koordinierungsstelle Frankfurt (FM01)

Research Program(s):

1. 899 - ohne Topic (POF4-899) (POF4-899)

Appears in the scientific report 2026

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Database coverage:
; ; ; Article Processing Charges ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; DOAJ Seal ; Ebsco Academic Search ; Essential Science Indicators ; Fees ; IF >= 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection ; Zoological Record

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