Journal Article

DKFZ-2026-01207

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png INSTALLing recombinase-driven genome writing: Engineered single-stranded donors bypass innate immunity to enable large DNA integration.

Buchholz, F.DKFZ*

2026
Cell Press [Cambridge, Mass.]

Abstract: In a recent Nature article, Tou et al.1 introduce INSTALL, a strategy that couples immune-evasive circular single-stranded DNA (cssDNA) technology with recombinase-based genome editing to overcome innate immune barriers and enable the integration of large DNA cargos.

Keyword(s): Immunity, Innate: genetics (MeSH) ; DNA, Single-Stranded: genetics (MeSH) ; DNA, Single-Stranded: immunology (MeSH) ; Humans (MeSH) ; Gene Editing: methods (MeSH) ; Recombinases: genetics (MeSH) ; Recombinases: metabolism (MeSH) ; CRISPR-Cas Systems (MeSH) ; DNA, Circular: genetics (MeSH) ; DNA, Circular: immunology (MeSH) ; DNA, Single-Stranded ; Recombinases ; DNA, Circular

Note: Spotlight

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Contributing Institute(s):

1. DKTK Koordinierungsstelle Dresden (DD01)

Research Program(s):

1. 899 - ohne Topic (POF4-899) (POF4-899)

Appears in the scientific report 2026

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 15 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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