DKFZ 92 records found  1 - 10nextend  jump to record: Search took 0.00 seconds. 
DBCoverage [DKFZ-2022-02247] Journal Article
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Erythropoietin-driven dynamic proteome adaptations during erythropoiesis prevent iron overload in the developing embryo.
Cell reports 40(12), 111360 () [10.1016/j.celrep.2022.111360]  GO
Erythropoietin (Epo) ensures survival and proliferation of colony-forming unit erythroid (CFU-E) progenitor cells and their differentiation to hemoglobin-containing mature erythrocytes. A lack of Epo-induced responses causes embryonic lethality, but mechanisms regulating the dynamic communication of cellular alterations to the organismal level remain unresolved. [...]
pmc [DKFZ-2022-01875] Journal Article
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Inhibition of hepatocellular carcinoma growth by blockade of glycosphingolipid synthesis.
OncoTarget 8(65), 109201 - 109216 () [10.18632/oncotarget.22648]  GO
Hepatocellular carcinoma (HCC) is one of the most frequent cancers. In vitro studies suggest that growth and response to therapy of human carcinomas may depend on glycosphingolipid (GSL) expression. [...]
[DKFZ-2020-03022] Journal Article
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CaM Kinase II-δ is Required for Diabetic Hyperglycemia and Retinopathy but not Nephropathy.
Diabetes 70(2), 616-626 () [10.2337/db19-0659]  GO
Type 2 diabetes has become a pandemic and leads to late diabetic complications of organs including kidney and eye. Lowering hyperglycemia is the typical therapeutic goal in clinical medicine. [...]
DBCoverage [DKFZ-2020-00991] Journal Article
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Development of a new macrophage-specific TRAP mouse (MacTRAP) and definition of the renal macrophage translational signature.
Tissue macrophages play an important role in organ homeostasis, immunity and the pathogenesis of various inflammation-driven diseases. One major challenge has been to selectively study resident macrophages in highly heterogeneous organs such as kidney. [...]
DBCoverage [DKFZ-2020-00610] Journal Article
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Endothelial Notch signaling controls insulin transport in muscle.
The role of the endothelium is not just limited to acting as an inert barrier for facilitating blood transport. Endothelial cells (ECs), through expression of a repertoire of angiocrine molecules, regulate metabolic demands in an organ-specific manner. [...]
[DKFZ-2020-00523] Journal Article
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Gangliosides Modulate Insulin Secretion by Pancreatic Beta-Cells under Glucose Stress.
Glycobiology 30(9), 722-734 () [10.1093/glycob/cwaa022]  GO
In pancreatic beta cells the entry of glucose and downstream signaling for insulin release is regulated by the glucose transporter 2 (Glut2) in rodents. Dysfunction of the insulin-signaling cascade may lead to diabetes mellitus. [...]
[DKFZ-2020-00237] Journal Article
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Lymphangiogenesis in a mouse model of renal transplant rejection extends life span of the recipients.
Renal allograft rejection can be prevented by immunological tolerance, which may be associated with de novo formed lymphatic vessels in the donor kidney after transplantation in man. A suitable mouse model of renal allograft rejection in which lymphangiogenesis can be deliberately induced in the graft is critical for elucidating the mechanisms responsible for the association between attenuated transplant rejection and abundance of lymphatic vessels. [...]
DBCoverage [DKFZ-2019-02958] Journal Article (Review Article)
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Trends of renal diseases in Germany: review of a regional renal biopsy database from 1990 to 2013.
Clinical kidney journal 12(6), 795-800 () [10.1093/ckj/sfz023]  GO
Trends of renal diseases in Germany: review of a regional renal biopsy database from 1990 to 2013..
[DKFZ-2019-02528] Journal Article
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Reproducibility of the Oxford classification of immunoglobulin A nephropathy, impact of biopsy scoring on treatment allocation and clinical relevance of disagreements: evidence from the VALidation of IGA study cohort.
The VALidation of IGA (VALIGA) study investigated the utility of the Oxford Classification of immunoglobulin A nephropathy (IgAN) in 1147 patients from 13 European countries. Methods. [...]

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