DKFZ 5 records found  Search took 0.01 seconds. 
[DKFZ-2022-00855] Journal Article
; ; ; et al
MYCN mediates cysteine addiction and sensitizes neuroblastoma to ferroptosis.
Nature cancer 3(4), 471 - 485 () [10.1038/s43018-022-00355-4]  GO
Aberrant expression of MYC transcription factor family members predicts poor clinical outcome in many human cancers. Oncogenic MYC profoundly alters metabolism and mediates an antioxidant response to maintain redox balance. [...]
[DKFZ-2022-00846] Journal Article
; ; ; et al
Perivascular tenascin C triggers sequential activation of macrophages and endothelial cells to generate a pro-metastatic vascular niche in the lungs.
Nature cancer 3(4), 486-504 () [10.1038/s43018-022-00353-6]  GO
Disseminated cancer cells frequently lodge near vasculature in secondary organs. However, our understanding of the cellular crosstalk invoked at perivascular sites is still rudimentary. [...]
DBCoverage [DKFZ-2020-00632] Journal Article
; ; ; et al
Metastasis-initiating cells induce and exploit a fibroblast niche to fuel malignant colonization of the lungs.
Metastatic colonization relies on interactions between disseminated cancer cells and the microenvironment in secondary organs. Here, we show that disseminated breast cancer cells evoke phenotypic changes in lung fibroblasts, forming a supportive metastatic niche. [...]
DBCoverage [DKFZ-2018-01452] Journal Article
; ; ; et al
Stress signaling in breast cancer cells induces matrix components that promote chemoresistant metastasis.
Metastatic progression remains a major burden for cancer patients and is associated with eventual resistance to prevailing therapies such as chemotherapy. Here, we reveal how chemotherapy induces an extracellular matrix (ECM), wound healing, and stem cell network in cancer cells via the c-Jun N-terminal kinase (JNK) pathway, leading to reduced therapeutic efficacy. [...]

Interested in being notified about new results for this query?
Set up a personal email alert or subscribe to the RSS feed.