DKFZ 8 records found  Search took 0.00 seconds. 
[DKFZ-2022-02486] Journal Article
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Regulatory T cell-derived interleukin-15 promotes the diversity of immunological memory.
While the immunosuppressive function of regulatory T (Treg) cells has been extensively studied, their immune-supportive roles have been less well investigated. Using a lymphocytic choriomeningitis virus (LCMV) Armstrong infection mouse model, we found that Treg cell-derived interleukin (IL)-15 is required for long-term maintenance of the KLRG1+ IL-7Rα- CD62L- terminal effector memory CD8+ T (tTEM) cell subset, but dispensable for the suppressive function of Treg cells themselves. [...]
[DKFZ-2022-01105] Journal Article
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Rgs16 promotes antitumor CD8+ T cell exhaustion.
T cells become functionally exhausted in tumors, limiting T cell-based immunotherapies. Although several transcription factors regulating the exhausted T (Tex) cell differentiation are known, comparatively little is known about the regulators of Tex cell survival. [...]
[DKFZ-2021-02326] Journal Article
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The Epstein-Barr virus noncoding RNA EBER2 transactivates the UCHL1 deubiquitinase to accelerate cell growth.
The Epstein-Barr virus (EBV) transforms resting B cells and is involved in the development of B cell lymphomas. We report here that the viral noncoding RNA EBER2 accelerates B cell growth by potentiating expression of the UCHL1 deubiquitinase that itself increased expression of the Aurora kinases and of cyclin B1. [...]
DBCoverage [DKFZ-2020-01113] Journal Article
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Skeletal muscle antagonizes antiviral CD8+ T cell exhaustion.
Science advances 6(24), eaba3458 - () [10.1126/sciadv.aba3458]  GO
CD8+ T cells become functionally impaired or 'exhausted' in chronic infections, accompanied by unwanted body weight reduction and muscle mass loss. Whether muscle regulates T cell exhaustion remains incompletely understood. [...]
DBCoverage [DKFZ-2020-00771] Journal Article
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T Cell Factor 1 Suppresses CD103+ Lung Tissue-Resident Memory T Cell Development.
T cell factor 1 (Tcf1) promotes the central memory CD8+ T (TCM) cell differentiation and stemness in lymphoid tissues after systemic infections. It remains unclear whether Tcf1 regulates the CD103high tissue-resident memory CD8+ T (TRM) cell formation in non-lymphoid tissues after mucosal infections. [...]
[DKFZ-2019-01371] Journal Article
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Loss of Neurological Disease HSAN-I-Associated Gene SPTLC2 Impairs CD8+ T Cell Responses to Infection by Inhibiting T Cell Metabolic Fitness.
Immunity 50(5), 1218 - 1231.e5 () [10.1016/j.immuni.2019.03.005]  GO
Patients with the neurological disorder HSAN-I suffer frequent infections, attributed to a lack of pain sensation and failure to seek care for minor injuries. Whether protective CD8+ T cells are affected in HSAN-I patients remains unknown. [...]
[DKFZ-2019-01309] Journal Article
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Regulatory T cells sense effector T-cell activation through synchronized JunB expression.
FEBS letters 593(10), 1020-1029 () [10.1002/1873-3468.13393]  GO
To maintain immune tolerance, effector T-cell (Teff) responses must be checked by the regulatory T cells (Tregs) in time. It remains incompletely understood how Tregs sense real-time Teff activation. [...]

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