DKFZ 3 records found  Search took 0.00 seconds. 
[DKFZ-2022-00499] Journal Article
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Rosette-forming glioneuronal tumours are midline, FGFR1-mutated tumours.
Rosette-forming glioneuronal tumour (RGNT) is a rare CNS WHO grade 1 brain neoplasm. According to WHO 2021, essential diagnostic criteria are a 'biphasic histomorphology with neurocytic and a glial component, and uniform neurocytes forming rosettes and/or perivascular pseudorosettes associated with synaptophysin expression' and/or DNA methylation profile of RGNT whereas 'FGFR1 mutation with co-occurring PIK3CA and/or NF1 mutation' are desirable criteria.We report a series of 46 cases fulfilling the essential pathological diagnostic criteria for RGNT. [...]
[DKFZ-2021-00909] Journal Article
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Glioblastomas with primitive neuronal component harbor a distinct methylation and copy-number profile with inactivation of TP53, PTEN, and RB1.
Glioblastoma IDH-wildtype presents with a wide histological spectrum. Some features are so distinctive that they are considered as separate histological variants or patterns for the purpose of classification. [...]

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