DKFZ 2 records found  Search took 0.01 seconds. 
[DKFZ-2022-03131] Journal Article
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Expression, cellular distribution, and prognostic relevance of TRAIL receptors in hepatocellular carcinoma.
After the advent of targeted therapies for hepatocellular carcinoma (HCC), much work is being done to provide a comprehensive description of the different signaling pathways contributing to cell survival and proliferation in this tumor. Apoptotic signaling mediated by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) represents an important mechanism of tumor surveillance, but its importance in the development of HCC is not known. [...]
DBCoverage [DKFZ-2022-03128] Journal Article
; ; ; et al
Microsatellite instability, KRAS mutations and cellular distribution of TRAIL-receptors in early stage colorectal cancer.
PLOS ONE 7(12), e51654 () [10.1371/journal.pone.0051654]  GO
The fact that the receptors for the TNF-related apoptosis inducing ligand (TRAIL) are almost invariably expressed in colorectal cancer (CRC) represents the rationale for the employment of TRAIL-receptors targeting compounds for the therapy of patients affected by this tumor. Yet, first reports on the use of these bioactive agents provided disappointing results. [...]

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