DKFZ 11 records found  1 - 10next  jump to record: Search took 0.00 seconds. 
DBCoverage [DKFZ-2022-01528] Journal Article
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Hyperglycemia Enhances Immunosuppression and Aerobic Glycolysis of Pancreatic Cancer Through Upregulating Bmi1-UPF1-HK2 Pathway.
Accumulating evidence strongly suggests that hyperglycemia promotes the progression of pancreatic cancer (PC). Approximately 80% of PC patients are intolerant to hyperglycemic conditions. [...]
pmc [DKFZ-2021-02222] Journal Article
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Genome-wide homozygosity and risk of four non-Hodgkin lymphoma subtypes.
Recessive genetic variation is thought to play a role in non-Hodgkin lymphoma (NHL) etiology. Runs of homozygosity (ROH), defined based on long, continuous segments of homozygous SNPs, can be used to estimate both measured and unmeasured recessive genetic variation. [...]
[DKFZ-2021-01388] Journal Article
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Functional annotation of the 2q35 breast cancer risk locus implicates a structural variant in influencing activity of a long-range enhancer element.
A combination of genetic and functional approaches has identified three independent breast cancer risk loci at 2q35. A recent fine-scale mapping analysis to refine these associations resulted in 1 (signal 1), 5 (signal 2), and 42 (signal 3) credible causal variants at these loci. [...]
[DKFZ-2021-00697] Journal Article
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Prospective evaluation of a breast-cancer risk model integrating classical risk factors and polygenic risk in 15 cohorts from six countries.
Rigorous evaluation of the calibration and discrimination of breast-cancer risk-prediction models in prospective cohorts is critical for applications under clinical guidelines. We comprehensively evaluated an integrated model incorporating classical risk factors and a 313-variant polygenic risk score (PRS) to predict breast-cancer risk.Fifteen prospective cohorts from six countries with 239 340 women (7646 incident breast-cancer cases) of European ancestry aged 19-75 years were included. [...]
[DKFZ-2020-00956] Journal Article
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Combined associations of a polygenic risk score and classical risk factors with breast cancer risk.
We evaluated the joint associations between a new 313-variant PRS (PRS313) and questionnaire-based breast cancer risk factors for women of European ancestry, using 72,284 cases and 80,354 controls from the Breast Cancer Association Consortium. Interactions were evaluated using standard logistic regression, and a newly developed case-only method, for breast cancer risk overall and by estrogen receptor status. [...]
DBCoverage [DKFZ-2019-02571] Journal Article
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The FANCM:p.Arg658* truncating variant is associated with risk of triple-negative breast cancer.
Breast cancer is a common disease partially caused by genetic risk factors. Germline pathogenic variants in DNA repair genes BRCA1, BRCA2, PALB2, ATM, and CHEK2 are associated with breast cancer risk. [...]
DBCoverage [DKFZ-2019-02561] Journal Article (Erratum/Correction)
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Author Correction: The challenge of mapping the human connectome based on diffusion tractography.
An amendment to this paper has been published and can be accessed via a link at the top of the paper..
DBCoverage [DKFZ-2019-02125] Journal Article
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Two truncating variants in FANCC and breast cancer risk.
Fanconi anemia (FA) is a genetically heterogeneous disorder with 22 disease-causing genes reported to date. In some FA genes, monoallelic mutations have been found to be associated with breast cancer risk, while the risk associations of others remain unknown. [...]
[DKFZ-2019-01697] Journal Article
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The genetic interplay between body mass index, breast size and breast cancer risk: a Mendelian randomization analysis.
Evidence linking breast size to breast cancer risk has been inconsistent, and its interpretation is often hampered by confounding factors such as body mass index (BMI). Here, we used linkage disequilibrium score regression and two-sample Mendelian randomization (MR) to examine the genetic associations between BMI, breast size and breast cancer risk.Summary-level genotype data from 23andMe, Inc (breast size, n = 33 790), the Breast Cancer Association Consortium (breast cancer risk, n = 228 951) and the Genetic Investigation of ANthropometric Traits (BMI, n = 183 507) were used for our analyses. [...]
DBCoverage [DKFZ-2017-06031] Journal Article
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The challenge of mapping the human connectome based on diffusion tractography.
Tractography based on non-invasive diffusion imaging is central to the study of human brain connectivity. To date, the approach has not been systematically validated in ground truth studies. [...]

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