DKFZ 23 records found  1 - 10nextend  jump to record: Search took 0.00 seconds. 
DBCoverage [DKFZ-2022-02551] Journal Article
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Common variability in oestrogen-related genes and pancreatic ductal adenocarcinoma risk in women
The incidence of pancreatic ductal adenocarcinoma (PDAC) is different among males and females. This disparity cannot be fully explained by the difference in terms of exposure to known risk factors; therefore, the lower incidence in women could be attributed to sex-specific hormones. [...]
DBCoverage [DKFZ-2021-03217] Journal Article
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Identification of Recessively Inherited Genetic Variants Potentially Linked to Pancreatic Cancer Risk.
Although 21 pancreatic cancer susceptibility loci have been identified in individuals of European ancestry through genome-wide association studies (GWASs), much of the heritability of pancreatic cancer risk remains unidentified. A recessive genetic model could be a powerful tool for identifying additional risk variants. [...]
[DKFZ-2021-02237] Journal Article
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Genetic polymorphisms involved in mitochondrial metabolism and pancreatic cancer risk.
The mitochondrial metabolism has been associated with pancreatic ductal adenocarcinoma (PDAC) risk. Recent evidence also suggests the involvement of the genetic variability of the mitochondrial function in several traits involved in PDAC aetiology. [...]
DBCoverage [DKFZ-2021-02176] Journal Article
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Association of Genetic Variants Affecting microRNAs and Pancreatic Cancer Risk.
Genetic factors play an important role in the susceptibility to pancreatic cancer (PC). However, established loci explain a small proportion of genetic heritability for PC; therefore, more progress is needed to find the missing ones. [...]
[DKFZ-2021-01513] Journal Article
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Associations between pancreatic expression quantitative traits and risk of pancreatic ductal adenocarcinoma.
Carcinogenesis 42(8), 1037–1045 () [10.1093/carcin/bgab057]  GO
Pancreatic ductal adenocarcinoma (PDAC) is among the most lethal cancers. Its poor prognosis is predominantly due to the fact that most patients remain asymptomatic until the disease reaches an advanced stage, alongside the lack of early markers and screening strategies. [...]
DBCoverage [DKFZ-2021-01436] Journal Article
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The alternative serotonin transporter promoter P2 impacts gene function in females with irritable bowel syndrome.
Irritable bowel syndrome (IBS) is a gut-brain disorder in which symptoms are shaped by serotonin acting centrally and peripherally. The serotonin transporter gene SLC6A4 has been implicated in IBS pathophysiology, but the underlying genetic mechanisms remain unclear. [...]
DBCoverage [DKFZ-2021-00830] Journal Article
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Lack of association of CD44-rs353630 and CHI3L2-rs684559 with pancreatic ductal adenocarcinoma survival.
Although pancreatic ductal adenocarcinoma (PDAC) survival is poor, there are differences in patients' response to the treatments. Detection of predictive biomarkers explaining these differences is of the utmost importance. [...]
[DKFZ-2021-00286] Journal Article
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Genome-wide scan of long noncoding RNA single nucleotide polymorphisms and pancreatic cancer susceptibility.
Pancreatic ductal adenocarcinoma (PDAC) is projected to become the second cancer-related cause of death by 2030. Identifying novel risk factors, including genetic risk loci, could be instrumental in risk stratification and implementation of prevention strategies. [...]
[DKFZ-2020-01093] Journal Article
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Polygenic and multifactorial scores for pancreatic ductal adenocarcinoma risk prediction.
Most cases of pancreatic ductal adenocarcinoma (PDAC) are asymptomatic in early stages, and the disease is typically diagnosed in advanced phases, resulting in very high mortality. Tools to identify individuals at high risk of developing PDAC would be useful to improve chances of early detection.We generated a polygenic risk score (PRS) for PDAC risk prediction, combining the effect of known risk SNPs, and carried out an exploratory analysis of a multifactorial score.We tested the associations of the individual known risk SNPs on up to 2851 PDAC cases and 4810 controls of European origin from the PANcreatic Disease ReseArch (PANDoRA) consortium. [...]

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