DKFZ 15 records found  1 - 10next  jump to record: Search took 0.01 seconds. 
[DKFZ-2022-02510] Journal Article
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Distinct germline genetic susceptibility profiles identified for common non-Hodgkin lymphoma subtypes.
Leukemia 36(12), 2835-2844 () [10.1038/s41375-022-01711-0]  GO
Lymphoma risk is elevated for relatives with common non-Hodgkin lymphoma (NHL) subtypes, suggesting shared genetic susceptibility across subtypes. To evaluate the extent of mutual heritability among NHL subtypes and discover novel loci shared among subtypes, we analyzed data from eight genome-wide association studies within the InterLymph Consortium, including 10,629 cases and 9505 controls. [...]
pmc [DKFZ-2021-02222] Journal Article
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Genome-wide homozygosity and risk of four non-Hodgkin lymphoma subtypes.
Recessive genetic variation is thought to play a role in non-Hodgkin lymphoma (NHL) etiology. Runs of homozygosity (ROH), defined based on long, continuous segments of homozygous SNPs, can be used to estimate both measured and unmeasured recessive genetic variation. [...]
DBCoverage [DKFZ-2020-00546] Journal Article
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Genetically Determined Height and Risk of Non-hodgkin Lymphoma.
Although the evidence is not consistent, epidemiologic studies have suggested that taller adult height may be associated with an increased risk of some non-Hodgkin lymphoma (NHL) subtypes. Height is largely determined by genetic factors, but how these genetic factors may contribute to NHL risk is unknown. [...]
[DKFZ-2019-02036] Journal Article
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Genetic overlap between autoimmune diseases and non-Hodgkin lymphoma subtypes.
Genetic epidemiology 43(7), 844-863 () [10.1002/gepi.22242]  GO
Epidemiologic studies show an increased risk of non-Hodgkin lymphoma (NHL) in patients with autoimmune disease (AD), due to a combination of shared environmental factors and/or genetic factors, or a causative cascade: chronic inflammation/antigen-stimulation in one disease leads to another. Here we assess shared genetic risk in genome-wide-association-studies (GWAS). [...]
pmc [DKFZ-2018-01266] Journal Article
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HLA Class I and II Diversity Contributes to the Etiologic Heterogeneity of Non-Hodgkin Lymphoma Subtypes.
Cancer research 78(14), 4086 - 4096 () [10.1158/0008-5472.CAN-17-2900]  GO
A growing number of loci within the human leukocyte antigen (HLA) region have been implicated in non-Hodgkin lymphoma (NHL) etiology. Here, we test a complementary hypothesis of 'heterozygote advantage' regarding the role of HLA and NHL, whereby HLA diversity is beneficial and homozygous HLA loci are associated with increased disease risk. [...]
DBCoverage [DKFZ-2017-06247] Journal Article
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Genome-wide association study of classical Hodgkin lymphoma identifies key regulators of disease susceptibility.
Several susceptibility loci for classical Hodgkin lymphoma have been reported. However, much of the heritable risk is unknown. [...]
DBCoverage [DKFZ-2017-06157] Journal Article
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Lupus-related single nucleotide polymorphisms and risk of diffuse large B-cell lymphoma.
Determinants of the increased risk of diffuse large B-cell lymphoma (DLBCL) in SLE are unclear. Using data from a recent lymphoma genome-wide association study (GWAS), we assessed whether certain lupus-related single nucleotide polymorphisms (SNPs) were also associated with DLBCL.GWAS data on European Caucasians from the International Lymphoma Epidemiology Consortium (InterLymph) provided a total of 3857 DLBCL cases and 7666 general-population controls. [...]
DBCoverage [DKFZ-2017-05717] Journal Article
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Occupation and Risk of Non-Hodgkin Lymphoma and Its Subtypes: A Pooled Analysis from the InterLymph Consortium.
Various occupations have been associated with an elevated risk of non-Hodgkin lymphoma (NHL), but results have been inconsistent across studies.We investigated occupational risk of NHL and of four common NHL subtypes with particular focus on occupations of a priori interest.We conducted a pooled analysis of 10,046 cases and 12,025 controls from 10 NHL studies participating in the InterLymph Consortium. We harmonized the occupational coding using the 1968 International Standard Classification of Occupations (ISCO-1968) and grouped occupations previously associated with NHL into 25 a priori groups. [...]
pmc [DKFZ-2017-05106] Journal Article
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Genetically predicted longer telomere length is associated with increased risk of B-cell lymphoma subtypes.
Human molecular genetics 25(8), 1663 - 1676 () [10.1093/hmg/ddw027]  GO
Evidence from a small number of studies suggests that longer telomere length measured in peripheral leukocytes is associated with an increased risk of non-Hodgkin lymphoma (NHL). However, these studies may be biased by reverse causation, confounded by unmeasured environmental exposures and might miss time points for which prospective telomere measurement would best reveal a relationship between telomere length and NHL risk. [...]
pmc [DKFZ-2017-04367] Journal Article
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Genome-wide association study identifies five susceptibility loci for follicular lymphoma outside the HLA region.
Genome-wide association studies (GWASs) of follicular lymphoma (FL) have previously identified human leukocyte antigen (HLA) gene variants. To identify additional FL susceptibility loci, we conducted a large-scale two-stage GWAS in 4,523 case subjects and 13,344 control subjects of European ancestry. [...]

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