DKFZ 2 records found  Search took 0.00 seconds. 
pmc [DKFZ-2022-03111] Journal Article
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MNK Inhibition Sensitizes KRAS-Mutant Colorectal Cancer to mTORC1 Inhibition by Reducing eIF4E Phosphorylation and c-MYC Expression.
Cancer discovery 11(5), 1228 - 1247 () [10.1158/2159-8290.CD-20-0652]  GO
KRAS-mutant colorectal cancers are resistant to therapeutics, presenting a significant problem for ∼40% of cases. Rapalogs, which inhibit mTORC1 and thus protein synthesis, are significantly less potent in KRAS-mutant colorectal cancer. [...]
[DKFZ-2021-00062] Journal Article
; ; ; et al
The amino acid transporter SLC7A5 is required for efficient growth of KRAS-mutant colorectal cancer.
Nature genetics 53(1), 16 - 26 () [10.1038/s41588-020-00753-3]  GO
Oncogenic KRAS mutations and inactivation of the APC tumor suppressor co-occur in colorectal cancer (CRC). Despite efforts to target mutant KRAS directly, most therapeutic approaches focus on downstream pathways, albeit with limited efficacy. [...]

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