DKFZ 3 records found  Search took 0.00 seconds. 
DBCoverage [DKFZ-2018-01851] Journal Article
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A systems biology network analysis of nutri(epi)genomic changes in endothelial cells exposed to epicatechin metabolites.
Although vasculo-protective effects of flavan-3-ols are widely accepted today, their impact on endothelial cell functions and molecular mechanisms of action involved is not completely understood. The aim of this study was to characterize the potential endothelium-protective effects of circulating epicatechin metabolites and to define underlying mechanisms of action by an integrated systems biology approach. [...]
pmc [DKFZ-2018-01301] Journal Article
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Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma.
High-risk neuroblastoma is a devastating malignancy with very limited therapeutic options. Here, we identify withaferin A (WA) as a natural ferroptosis-inducing agent in neuroblastoma, which acts through a novel double-edged mechanism. [...]

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