DKFZ 9 records found  Search took 0.01 seconds. 
[DKFZ-2020-00628] Journal Article
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Genetic predictors of circulating 25-hydroxyvitamin D and prognosis after colorectal cancer.
Low serum 25-hydroxyvitamin D (25(OH)D) concentrations in colorectal cancer (CRC) patients have been consistently associated with higher mortality in observational studies. It is unclear whether low 25(OH)D levels directly influence CRC mortality. [...]
pmc [DKFZ-2019-00659] Journal Article
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Cardiovascular Risk Factors Associated With Venous Thromboembolism.
It is uncertain to what extent established cardiovascular risk factors are associated with venous thromboembolism (VTE).To estimate the associations of major cardiovascular risk factors with VTE, ie, deep vein thrombosis and pulmonary embolism.This study included individual participant data mostly from essentially population-based cohort studies from the Emerging Risk Factors Collaboration (ERFC; 731 728 participants; 75 cohorts; years of baseline surveys, February 1960 to June 2008; latest date of follow-up, December 2015) and the UK Biobank (421 537 participants; years of baseline surveys, March 2006 to September 2010; latest date of follow-up, February 2016). Participants without cardiovascular disease at baseline were included. [...]
[DKFZ-2018-01976] Journal Article
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Associations of obesity and circulating insulin and glucose with breast cancer risk: a Mendelian randomization analysis.
In addition to the established association between general obesity and breast cancer risk, central obesity and circulating fasting insulin and glucose have been linked to the development of this common malignancy. Findings from previous studies, however, have been inconsistent, and the nature of the associations is unclear.We conducted Mendelian randomization analyses to evaluate the association of breast cancer risk, using genetic instruments, with fasting insulin, fasting glucose, 2-h glucose, body mass index (BMI) and BMI-adjusted waist-hip-ratio (WHRadj BMI). [...]
[DKFZ-2018-01273] Journal Article
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A transcriptome-wide association study of 229,000 women identifies new candidate susceptibility genes for breast cancer.
Nature genetics 50(7), 968 - 978 () [10.1038/s41588-018-0132-x]  GO
The breast cancer risk variants identified in genome-wide association studies explain only a small fraction of the familial relative risk, and the genes responsible for these associations remain largely unknown. To identify novel risk loci and likely causal genes, we performed a transcriptome-wide association study evaluating associations of genetically predicted gene expression with breast cancer risk in 122,977 cases and 105,974 controls of European ancestry. [...]
[DKFZ-2017-06192] Journal Article
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Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer.
Nature genetics 49(12), 1767 - 1778 () [10.1038/ng.3785]  GO
Most common breast cancer susceptibility variants have been identified through genome-wide association studies (GWAS) of predominantly estrogen receptor (ER)-positive disease. We conducted a GWAS using 21,468 ER-negative cases and 100,594 controls combined with 18,908 BRCA1 mutation carriers (9,414 with breast cancer), all of European origin. [...]
[DKFZ-2017-05966] Journal Article
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Association analysis identifies 65 new breast cancer risk loci.
Nature <London> 551(7678), 92 - 94 () [10.1038/nature24284]  GO
Breast cancer risk is influenced by rare coding variants in susceptibility genes, such as BRCA1, and many common, mostly non-coding variants. However, much of the genetic contribution to breast cancer risk remains unknown. [...]
pmc [DKFZ-2017-02889] Journal Article
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Identification of a common variant with potential pleiotropic effect on risk of inflammatory bowel disease and colorectal cancer.
Carcinogenesis 36(9), 999 - 1007 () [10.1093/carcin/bgv086]  GO
Although genome-wide association studies (GWAS) have separately identified many genetic susceptibility loci for ulcerative colitis (UC), Crohn's disease (CD) and colorectal cancer (CRC), there has been no large-scale examination for pleiotropy, or shared genetic susceptibility, for these conditions. We used logistic regression modeling to examine the associations of 181 UC and CD susceptibility variants previously identified by GWAS with risk of CRC using data from the Genetics and Epidemiology of Colorectal Cancer Consortium and the Colon Cancer Family Registry. [...]
pmc [DKFZ-2017-00146] Journal Article
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Biomarkers of one-carbon metabolism are associated with biomarkers of inflammation in women.
The journal of nutrition 144(5), 714 - 721 () [10.3945/jn.113.183970]  GO
Folate-mediated one-carbon metabolism is essential for DNA synthesis, repair, and methylation. Perturbations in one-carbon metabolism have been implicated in increased risk of some cancers and may also affect inflammatory processes. [...]

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