DKFZ 2 records found  Search took 0.00 seconds. 
[DKFZ-2020-00407] Journal Article
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IGLV3-21*01 is an inherited risk factor for CLL through the acquisition of a single-point mutation enabling autonomous BCR signaling.
The prognosis of chronic lymphocytic leukemia (CLL) depends on different markers, including cytogenetic aberrations, oncogenic mutations, and mutational status of the immunoglobulin (Ig) heavy-chain variable (IGHV) gene. The number of IGHV mutations distinguishes mutated (M) CLL with a markedly superior prognosis from unmutated (UM) CLL cases. [...]
[DKFZ-2018-01305] Journal Article
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Antihomotypic affinity maturation improves human B cell responses against a repetitive epitope.
Science 360(6395), 1358 - 1362 () [10.1126/science.aar5304]  GO
Affinity maturation selects B cells expressing somatically mutated antibody variants with improved antigen-binding properties to protect from invading pathogens. We determined the molecular mechanism underlying the clonal selection and affinity maturation of human B cells expressing protective antibodies against the circumsporozoite protein of the malaria parasite Plasmodium falciparum (PfCSP). [...]

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