DKFZ 5 records found  Search took 0.01 seconds. 
[DKFZ-2022-02304] Journal Article
; ; ; et al
Implementation of paediatric precision oncology into clinical practice: The Individualized Therapies for Children with cancer program 'iTHER'.
iTHER is a Dutch prospective national precision oncology program aiming to define tumour molecular profiles in children and adolescents with primary very high-risk, relapsed, or refractory paediatric tumours. Between April 2017 and April 2021, 302 samples from 253 patients were included. [...]
DBCoverage [DKFZ-2021-01917] Journal Article
; ; ; et al
Organoid-based drug screening reveals neddylation as therapeutic target for malignant rhabdoid tumors.
Malignant rhabdoid tumors (MRTs) represent one of the most aggressive childhood malignancies. No effective treatment options are available, and prognosis is, therefore, dismal. [...]
DBCoverage [DKFZ-2021-01433] Journal Article
; ; ; et al
Single cell derived mRNA signals across human kidney tumors.
Tumor cells may share some patterns of gene expression with their cell of origin, providing clues into the differentiation state and origin of cancer. Here, we study the differentiation state and cellular origin of 1300 childhood and adult kidney tumors. [...]
DBCoverage [DKFZ-2021-00542] Journal Article
; ; ; et al
Somatic mutations and single-cell transcriptomes reveal the root of malignant rhabdoid tumours.
Malignant rhabdoid tumour (MRT) is an often lethal childhood cancer that, like many paediatric tumours, is thought to arise from aberrant fetal development. The embryonic root and differentiation pathways underpinning MRT are not firmly established. [...]
DBCoverage [DKFZ-2020-00554] Journal Article
; ; ; et al
An organoid biobank for childhood kidney cancers that captures disease and tissue heterogeneity.
Kidney tumours are among the most common solid tumours in children, comprising distinct subtypes differing in many aspects, including cell-of-origin, genetics, and pathology. Pre-clinical cell models capturing the disease heterogeneity are currently lacking. [...]

Interested in being notified about new results for this query?
Set up a personal email alert or subscribe to the RSS feed.