Books

Imaging plays an important role in the early detection and staging of medullary thyroid carcinoma (MTC), as well as in follow-up to locate early recurrence. MTC is a rare, calcitonin-secreting thyroid malignancy that is often diagnosed by ultrasound and calcitonin screening as part of the routine evaluation of any thyroid nodule. [...]

Senescence is a cellular stress response causing a stable exit from the cell cycle. Limitation of cell proliferation is accompanied by a variety of characteristic changes, including cellular and nuclear morphological alterations, chromatin rearrangements, metabolic reprogramming, nuclear envelope rupture, and an immunomodulatory secretome, termed senescence-associated secreted phenotype (SASP). [...]

On the occasion of ISOTT's half-century, in this chapter, tumour hypoxia (i.e. critically reduced oxygen levels on macro- and microscopic scales), recently classified as an additional hallmark of cancer, its various aetiology-related classifications (diffusion- or perfusion-limitations, hypoxaemic), time-frames of exposure (acute, chronic, cyclic), and different levels (moderate, mild, severe) within and across tumours, and its Janus-face-like role ('dichotomy') in tumour regression (e.g. [...]