Books

In der modernen Medizin, insbesondere in den Bereichen Onkologie und seltene Erkrankungen, hat die genetische Diagnostik in den letzten Jahren zunehmend an Bedeutung gewonnen. Stetige Fortschritte in der Sequenziertechnologie und folglich sinkende Kosten ermöglichen heute die explorative Untersuchung mittels großer Genpanels bis hin zur Sequenzierung des gesamten Genoms. [...]

In modern medicine, particularly in the fields of oncology and rare diseases, genetic diagnostics has become increasingly important in recent years. Steady progress in sequencing technology and consequently decreasing costs now allow exploratory testing using large gene panels and even whole genome sequencing. [...]

Protein ubiquitylation is a post-translational modification, which can control various cellular processes. Ubiquitin is conjugated to a substrate by an enzymatic cascade comprising so-called ubiquitin writers: E1, E2 and E3 enzymes. [...]

Stopping power ratio (SPR) maps are needed for dose deposition calculations and are typically estimated from single energy CT (SECT) in clinical routine. SECT-based SPR conversion leads to large variability due to the one-to-one relationship assumed by the conversion method. [...]

Cancers are complex, heterogeneous, dynamic and aggressive diseases exhibiting a series of characteristic biophysical traits which complement the original biological hallmarks of cancers favouring progressive growth, metastasis, and contributing to immune evasion and treatment resistance. One of the prevalent differences between most solid tumors and their corresponding, healthy tissues is a significantly higher water content (hyperhydration) in cancers. [...]

The aim of this review is to stimulate readers to undertake appropriate investigations of the mechanism for a possible oxygen effect in FLASH. FLASH is a method of delivery of radiation that empirically, in animal models, appears to decrease the impact of radiation on normal tissues while retaining full effect on tumors. [...]

The increasing need for secondary use of clinical study data requires FAIR infrastructures, i.e. provide findable, accessible, interoperable and reusable data. [...]

Mass spectrometry (MS)-based proteomics is a rapidly maturing discipline, thus gaining momentum for routine molecular profiling of clinical specimens to improve disease classification, diagnostics, and therapy development. Yet, hurdles need to be overcome to enhance reproducibility in preanalytical sample processing, especially in large, quantity-limited sample cohorts. [...]

Interleukin (IL)-1β is a key mediator of inflammation and activates via pattern recognition receptors (PRR) of the inflammasome family by proteolytic maturation. Proteolysis is driven by proteases such as caspase-1 (also known as IL-1 converting enzyme, ICE) and converts the intact pro-IL-1β ~31 kDa pro-peptide into a mature, ~17 kDa form that can exit cells through nanomolecular pores or via microvesicles. [...]

During tumor growth, the complex composition of vasculature is prone to dynamic changes due to mechanic and biochemical challenges. Perivascular invasion of tumor cells to co-opt existing vasculature, but also formation of de-novo vasculature and other effects on the vascular network, may lead to altered geometric vessel properties as well as changes in vascular network topology, which is defined by vascular multifurcations and connections between vessel segments. [...]