Books

RNA-binding proteins are key mediators of many of the RNA-regulatory functions throughout the RNA life cycle in the nucleus and in the cytoplasm. The invention and the recent refinement of the RNA-interactome capture technology has now enabled the analysis of the global RNA-interactome in living cells in the nucleus and in the cytoplasm separately. [...]

Semantic segmentation is crucial for various biomedical applications, yet its reliance on large annotated datasets presents a bottleneck due to the high cost and specialized expertise required for manual labeling. Active Learning (AL) aims to mitigate this challenge by querying only the most informative samples, thereby reducing annotation effort [...]

Pretraining is a crucial step to improve the performance of deep learning models or to accelerate the training process. Ideal pretraining strategies enable fast adaptation to the target domain after pretraining and the development of foundation models. [...]

Major histocompatibility complex (MHC, or human leukocyte antigen, HLA) peptide ligands can be exploited to develop immunotherapies targeting immunogenic disease-specific immunopeptides, such as virus- or cancer mutation-derived peptides. Liquid chromatography coupled with mass spectrometry (LC-MS)-based immunopeptidomics is the gold standard for identifying MHC ligands. [...]

Every day billions of cells are removed in the human body by apoptosis. These apoptotic cells need to be rapidly and safely removed in order to avoid inflammation. [...]

Structural variants are of major importance in cancer genetics. Especially when it comes to the detection of complex structural variants as in chromoanagenesis, detection tools like array-CGH, karyotyping, or even whole-genome sequencing do not provide the necessary resolution and/or accuracy. [...]

Imaging plays an important role in the early detection and staging of medullary thyroid carcinoma (MTC), as well as in follow-up to locate early recurrence. MTC is a rare, calcitonin-secreting thyroid malignancy that is often diagnosed by ultrasound and calcitonin screening as part of the routine evaluation of any thyroid nodule. [...]

Senescence is a cellular stress response causing a stable exit from the cell cycle. Limitation of cell proliferation is accompanied by a variety of characteristic changes, including cellular and nuclear morphological alterations, chromatin rearrangements, metabolic reprogramming, nuclear envelope rupture, and an immunomodulatory secretome, termed senescence-associated secreted phenotype (SASP). [...]