Journal Article

Combining radiotherapy with immune checkpoint inhibitors (RT-ICI) triggers systemic antitumor responses, such as abscopal effects (AbE). Predictors of AbE and its impact on survival in real-world settings remain poorly defined. [...]

There is currently no individualized prognostic tool to predict outcomes in patients with brain tumors following status epilepticus (SE), despite its clinical importance for counseling and therapeutic decision-making. This proof-of-principle, retrospective monocentric study investigated whether electroencephalography (EEG)-derived functional connectivity patterns differ in brain tumor patients after SE with respect to survival and tumor type.EEG data from 37 brain tumor patients with SE were analyzed. [...]

Epstein-Barr virus is now regarded as the critical risk factor for multiple sclerosis. However, Cytomegalovirus and human herpesvirus 6A have also been associated with altered multiple sclerosis risk, suggesting a multifactorial aetiology. [...]

Background:High-sensitivity cardiac troponin T (hs-cTnT) is frequently elevated in cancer patients, but its clinical implications remain uncertain. We aimed to determine the prevalence of obstructive coronary artery disease (CAD) as a cause of hs-cTnT elevation and to evaluate the impact of cardiovascular risk factors and oncologic therapies.Methods:Between 2016 and 2023, 810 consecutive cancer patients with elevated hs-cTnT values presenting to the cardio-oncology outpatient clinic in Heidelberg were included. [...]

The preoperative logistics for operating room preparation require interdisciplinary cooperation between surgery, anesthesia, nursing and administration as well as a clear standardization of procedures to ensure safety and efficiency. The starting point is the patient presentation with diagnostics and interpretation of the indications, followed by surgical and anesthesiological preparation, which focuses on the clinical examination, information, additional diagnostics and, if necessary, nutritional measures. [...]

We aimed to evaluate the use of bevacizumab in patients with International Federation of Gynecology and Obstetrics stage IIIB to IV epithelial ovarian and fallopian tube cancer undergoing primary debulking surgery, using real-world data from a German cancer registry.Patients with a first diagnosis of International Federation of Gynecology and Obstetrics stage IIIB to IV epithelial ovarian or fallopian tube cancer diagnosed between 2009 and 2023 were identified from the Baden-Wuerttemberg Cancer Registry. Outcomes of patients receiving carboplatin and paclitaxel±bevacizumab were compared. [...]

The rapid digitalization of healthcare is transforming medical care strategies. Individuals carrying (likely) pathogenic TP53 germline variants (P/LP TP53) require complex surveillance protocols. [...]

Local control rates for pulmonary metastases from head and neck squamous cell carcinoma (HNSCC) treated with stereotactic body radiation therapy (SBRT) vary substantially in the literature, likely due to differences in the doses applied. This study, therefore, aims to develop tumor control probability (TCP) models.Dose-time modeling of TCP was performed for three key dose descriptors: 3-fraction equivalent dose (3fxED) prescription dose, 3fxED planning target volume (PTV) D95%, and 3fxED PTV D2%. [...]

Pediatric patients with high-risk extra-cranial solid tumors face a 5-year survival rate below 50%. As molecular profiling alone is insufficient to guide treatment at relapse, complementary strategies like drug screening are urgently needed. [...]