Journal Article

Epigenetic regulation and gene transcription are dynamically modulated by extracellular signals, including focal adhesions; however, the role of integrins in these processes remains poorly understood. In this study in HPV-negative head and neck squamous cell carcinoma, (HNSCC), we combined investigations in physiological three-dimensional, matrix-embedded cell models and patient-derived organoids with multi-omics analyses, bioinformatics and artificial intelligence, to unmask the integrin effector signaling network that reshapes chromatin to drive cancer. [...]

Despite major therapeutic advances, multiple myeloma (MM) remains largely incurable. Moreover, side effects and toxicities of treatments compromise patients' quality of life. [...]

The postprandial period provides a dynamic window to assess metabolic function, as nutrient intake elicits measurable shifts in metabolism, that can be used to assess health status. Traditional venipuncture, though standard for blood sampling, poses practical limitations for postprandial studies that require repeated collections. [...]

Anaplastic ependymoma is a rare and aggressive central nervous system malignancy for which effective systemic treatment options are limited. Trastuzumab deruxtecan (T-DXd), an antibody-drug conjugate targeting human epidermal growth factor receptor 2 (HER2), has demonstrated intracranial activity in patients with HER2-positive solid tumors. [...]

Robust confounder identification is essential for valid indirect treatment comparisons (ITCs), particularly in relapsed/refractory diffuse large B-cell lymphoma (R/R DLBCL), where treatment pathways are heterogeneous and comparative evidence between chimeric antigen receptor T-cell (CAR-T) therapies remains limited. This study aimed to validate clinically relevant prognostic factors and treatment-effect modifiers for comparative effectiveness analyses in DLBCL using a structured expert consensus approach.Candidate variables were identified through a prior systematic literature review and refined by clinical review. [...]

In grant applications, oral presentations can be an integral part of the evaluation process. Funding pitches are a specific form of pitch presentations delivered during competitive review procedures to complement a written proposal. [...]

In advanced cancer, associations among changes in body composition, cardiac wasting and prior cardiotoxic anticancer therapy have not been investigated.Using bioelectrical impedance analysis (BIA), body composition was measured in 206 patients with mostly advanced cancer without known cardiovascular disease or infection (stage III/IV: 84%, prior cardiotoxic anticancer therapy: 55%). Left ventricular (LV) mass was assessed by transthoracic echocardiography and grouped by presence of cardiac wasting according to previously established sex-specific thresholds for LV mass adjusted for height2 (<61 g/m2 for women, <57 g/m2 for men). [...]

To establish a standardised intraoperative hyperspectral imaging (HSI) human organ reference dataset and to characterise spectral signatures across organ classes as a foundation for future computational and clinical applications.Intraoperative assessment of anatomical structures and tissue quality such as perfusion or malignancy remains largely subjective and lacks quantitative, spatially resolved standards. Spectral imaging is a promising technology to address this ambition containing information content far beyond regular red, green, and blue light (RGB) imaging. [...]