Journal Article

Infection with the Epstein-Barr virus (EBV) is a major risk factor for the development of cancer and autoimmune disorders. The virus enters the body in the pharynx, but EBV causes disease in distant organs, including the gut and the brain. [...]

The tumor microenvironment (TME) influences cancer cell metabolism and survival. However, how immune and stromal cells respond to metabolic stress in vivo, and how nutrient limitations affect therapy, remains poorly understood. [...]

The intracellular pH (pHi) is critical for understanding various pathologies, including brain tumors. While conventional pHi measurement through 31P-MRS suffers from low spatial resolution and long scan times, 1H-based APT-CEST imaging offers higher resolution with shorter scan times. [...]

Inflammatory bowel disease (IBD) is a group of chronic inflammatory disorders, including ulcerative colitis (UC) and Crohn's disease, affecting the gastrointestinal tract and is associated with high morbidity and mortality. Accumulating evidence indicates that IBD not only impacts the gastrointestinal tract but also affects multiple extraintestinal organs, which may manifest prior to the diagnosis of IBD. [...]

Targeting people at risk of COVID-19 infection has been critical to containing the pandemic. Using only differences in cumulative incidence by sociodemographic groups can be misleading, as it reflects both factors related to infection risk and those related to testing for infection. [...]

Recent discoveries concerning the network architecture of glioblastoma, including tumor microtubules (TMs) and neuron-glioma synapses, have underscored critical pathways that sustain tumor growth, enhance resistance, and integrate glioblastoma with the surrounding neural environment. This review explores emerging therapeutic strategies targeting these pathways, including inhibitors of gap junctions, AMPA receptors, and glutamate signaling, which are currently being tested in clinical trials. [...]

Vision-language models (VLMs) integrate visual data, such as surgical videos and medical images, with textual information for advanced artificial intelligence (AI) capabilities in surgery. This mini review highlights recent developments in the application of VLMs to surgical tasks in urology, such as answering clinical questions about surgical images, recognizing surgical instruments, identifying surgical phases, and detecting errors during procedures. [...]