Journal Article

We showed previously that breast cancer patients with certain circadian rhythm genotypes have higher incidences of toxicity when treated with radiotherapy at different times of day. This opens the way to genetically-guided chronomodulation as a cost-effective way to reduce side-effects while preserving treatment efficacy. [...]

Helicobacter pylori (H. pylori), herpes simplex-1 (HSV-1), and varicella-zoster virus (VZV) could increase dementia risk; however, evidence from large cohorts with long-term follow-up is scarce.Multivariable-adjusted Cox proportional-hazards models were used to investigate the association between H. [...]

Cell migration is a fundamental biological process essential for embryonal development, immune function, and cancer metastasis, with migration velocity representing a key parameter of this behaviour. Today, cell migration velocity can be measured in high-throughput assays that generate complex, hierarchically structured datasets with technical noise, batch effects, and biological variability, introducing significant uncertainty in velocity estimates. [...]

The tyrosine kinase expressed in hepatocellular carcinoma (TEC) family comprises five nonreceptor tyrosine kinases─BTK, ITK, BMX, TXK, and TEC─with key roles in immune signaling. Although BTK and ITK have been extensively studied, selective inhibitors for TEC, TXK, and BMX remain scarce. [...]

Reactive oxygen species (ROS) are tightly regulated in the skin and implicated in both cancer and inflammatory dermatoses, but the role of oxidative stress in cutaneous T-cell lymphoma (CTCL) remains largely unexplored. Here we aim to characterize oxidative stress and redox homeostasis in CTCL and determine whether increased ROS creates a therapeutic vulnerability in malignant T-cells and whether it affects neighboring keratinocytes. [...]

Beta human papillomaviruses (betaHPVs) act as cofactors in keratinocyte carcinogenesis, but how they reprogram host gene regulation remains unclear. Here, we combined transcriptomic, small RNA and epigenomic profiling to dissect the impact of betaHPV8 oncogene expression on keratinocytes. [...]

To assess the effectiveness of a confirmatory prostate-specific antigen (PSA) test as a safeguard against unnecessary work-up and to improve the specificity of prostate cancer (PCa) screening.Overall, 72,157 PSA values corresponding to screening rounds at age 45-55 yr in the PROBASE trial were analyzed. Positive PSA tests were reported as the proportion of men with an initial or confirmatory PSA ≥3 ng/ml. [...]

The primary cilium (PC) is a microtubule-based mechanosensory organelle involved in signal transduction. Although the signaling functions of PC have been well studied, its interaction with the cell´s mechanical environment remains unclear. [...]

Strong expression of the 18 kDa translocator protein (TSPO) is observed in glioma and tumor-associated myeloid cells within the tumor microenvironment. However, TSPO expression also extends beyond the tumor and may reflect systemic immune regulation. [...]