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pmc [DKFZ-2023-02576] Preprint
; ; ; et al
Reviving immunogenic cell death upon targeting TACC3 enhances T-DM1 response in HER2-positive breast cancer.
bioRxiv nn, nn () [10.1101/2023.09.12.557273 ]  GO
Immunogenic cell death (ICD), an immune-priming form of cell death, has been shown to be induced by several different anti-cancer therapies. Despite being the first and one of the most successful antibody-drug conjugates (ADCs) approved for refractory HER2-positive breast cancer, little is known if response and resistance to trastuzumab emtansine (T-DM1) involves ICD modulation that can be leveraged to enhance T-DM1 response. [...]

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2023-11-23
10:50

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2023-09-04
09:29
arXiv [DKFZ-2023-01785] Preprint
; ; ; et al
Deployment of Image Analysis Algorithms under Prevalence Shifts
[arXiv:2303.12540]
Domain gaps are among the most relevant roadblocks in the clinical translation of machine learning (ML)-based solutions for medical image analysis. While current research focuses on new training paradigms and network architectures, little attention is given to the specific effect of prevalence shifts on an algorithm deployed in practice. [...]
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