2023-12-01 15:07 |
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2023-12-01 15:05 |
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2023-12-01 15:01 |
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2023-12-01 14:59 |
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2023-12-01 14:58 |
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2023-11-30 15:16 |
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2023-11-30 15:12 |
[DKFZ-2023-02514]
Journal Article
Mooshage, C. M. ; Tsilingiris, D. ; Schimpfle, L. ; et al
A diminished sciatic nerve structural integrity is associated with distinct peripheral sensory phenotypes in individuals with type 2 diabetes.
Quantitative sensory testing (QST) allows the identification of individuals with rapid progression of diabetic sensorimotor polyneuropathy (DSPN) based on certain sensory phenotypes. Hence, the aim of this study was to investigate the relationship of these phenotypes with the structural integrity of the sciatic nerve among individuals with type 2 diabetes.Seventy-six individuals with type 2 diabetes took part in this cross-sectional study and underwent QST of the right foot and high-resolution magnetic resonance neurography including diffusion tensor imaging of the right distal sciatic nerve to determine the sciatic nerve fractional anisotropy (FA) and cross-sectional area (CSA), both of which serve as markers of structural integrity of peripheral nerves. [...]
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2023-11-30 15:09 |
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2023-11-30 15:07 |
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2023-11-30 15:02 |
[DKFZ-2023-02511]
Journal Article
Stoecklein, S. ; Wunderlich, S. ; Papazov, B. ; et al
Functional connectivity MRI provides an imaging correlate for chimeric antigen receptor T-cell-associated neurotoxicity.
Treatment of hematological malignancies with chimeric antigen receptor modified T cells (CART) is highly efficient, but often limited by an immune effector cell-associated neurotoxicity syndrome (ICANS). As conventional MRI is often unremarkable during ICANS, we aimed to examine whether resting-state functional MRI (rsfMRI) is suitable to depict and quantify brain network alterations underlying ICANS in the individual patient.The dysconnectivity index (DCI) based on rsfMRI was longitudinally assessed in systemic lymphoma patients and 1 melanoma patient during ICANS and before or after clinical resolution of ICANS.Seven lymphoma patients and 1 melanoma patient (19-77 years; 2 female) were included. [...]
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