Publications database

Pancreatic cancer (PCA) can have a hereditary component linked to pathogenic germline variants (PGVs) in multiple cancer predisposition genes in app. 10-20 % of patients. [...]

Adoptive transfer of regulatory T cells (Tregs) has demonstrated safety, feasibility and early signs of efficacy in promoting immunological tolerance in inflammatory conditions such as graft-versus-host disease (GvHD). Chimeric antigen receptor (CAR)-engineered Tregs offer localized activation and suppression compared to polyclonal Tregs, but their clinical translation is limited by high manufacturing costs, lengthy developing times and fixed single-antigen specificity. [...]

Robot-assisted thoracoscopy (RATS) is rapidly emerging as the preferred approach for the resection of thymic epithelial tumors (TET). Current challenges include the role of RATS in locally advanced disease and combined additional resections.This single-center study included all consecutive robot-assisted surgeries for TET performed between 2018 and 2024. [...]

The prognostic role of dendritic cells (DCs) in colorectal cancer (CRC) and paired liver metastases (LM) remains unclear, particularly regarding the dynamics of immature CD1a+ and mature CD208+ subsets across anatomical compartments and synchronous versus metachronous disease.This retrospective cohort included patients undergoing resection of primary CRC (pCRC) and synchronous LM (N = 55) or metachronous LM (N = 44). Immunohistochemical staining for CD1a and CD208 was performed on non-tumor adjacent mucosa (NAM), as well as tumor center (TC), inner margin (IM), outer margin (OM), and peritumoral zone (PT) of both pCRC and LM. [...]

Recent advances in ultrahigh-field MRI have led to accelerated adoption in clinical applications, especially after regulatory approval for 7-T MRI systems. The substantial gains in signal-to-noise ratio, tissue contrast, chemical shift, and susceptibility effects enable unprecedented image resolution and quality, resulting in more accurate diagnoses and improved treatment planning. [...]

Epigenetic aberrations are key drivers of multiple myeloma, yet targeted therapies exploiting epigenetic alterations have not been established. By integrating clinical and molecular datasets of patients with multiple myeloma with an unbiased genetic in vivo screen, we identified KAT8 regulatory NSL complex subunit 2 (KANSL2) as a histone posttranslational modification-associated candidate oncogene. [...]

The intestinal microbiome influences health and disease. Its composition is affected by host genetics and environmental exposures. [...]

Most neuroendocrine cancers lack caspase 8 protein expression. While this feature was thought to facilitate escape from extrinsic apoptosis, its cancer-regulatory function has remained unexplored. [...]

Malignant ovarian germ cell tumors (MOGCT) and ovarian sex cord stromal tumors (SCST) are rare ovarian tumors. Since 2013, all German federal states are obliged to record data on diagnosis, pathology, therapy, and clinical course of tumor diseases. [...]