Publications database

In 2023, the G7 Cancer Initiative was launched by Australia, Canada, France, Germany, Japan, the United Kingdom, and the United States with the aim of enhancing global cancer control, and with poor-prognosis cancers as a priority. To facilitate effective collaboration among G7 Cancer, we aimed to address the lack of standardized definitions and coordinated initiatives across countries.We examined how the G7 Cancer Initiative countries defined poor-prognosis cancers, objectively classified them, quantified their burden, and assessed national response strategies. [...]

Deep learning (DL) methods enable photon dose calculation under two main coordinate representations: Beam's Eye View (BEV) and patient coordinates. We evaluate dose calculation accuracy and speed under these coordinate paradigms and with representative DL models within a unified dataset and pipeline, and introduce two lightweight models for fast photon dose calculation.Planning computed tomography (CT) scans and volumetric modulated arc therapy (VMAT) plans from 24 prostate cancer patients were used. [...]

Vazquez et al. High frequency of CD95+/CD45RA- regulatory T cells defines an immunosuppressive profile associated with MDS progression. [...]

Children with Down syndrome have a 150-fold increased risk of developing myeloid leukaemia (ML-DS). Unusually for a childhood leukaemia, ML-DS arises from a preleukaemic state, termed transient abnormal myelopoiesis (TAM), via a conserved sequence of mutations. [...]

Amyloid beta (Aβ) plaque deposition in the central nervous system (CNS) is a hallmark of Alzheimer's disease (AD) and cerebral amyloid angiopathy (CAA), triggering robust innate immune responses. However, the role of the adaptive immune system remains less well understood. [...]

This study aims to identify immediate and long-term predictors of postoperative urinary continence recovery after robotic-assisted radical prostatectomy (RARP) in a cohort of 1061 patients, enabling risk stratification and informing potentially modifiable perioperative strategies across patient subgroups.Prospectively collected data from 1061 patients who underwent RARP between 2016 and 2021 at a single high-volume hospital were analysed. Urinary continence was evaluated immediately after surgery (n = 1061), after 1 year (n = 797) and after 3 years (n = 621). [...]

Uro-oncology is moving toward precision medicine, driven by high-dimensional longitudinal data from imaging, pathology, molecular profiling, and follow-up. However, clinical decision-making often relies on static risk scores that cannot fully capture individual disease dynamics. [...]

Cancer is frequently accompanied by cachexia, a systemic syndrome characterized by progressive loss of skeletal muscle mass, with or without loss of fat mass. Increasing evidence indicates that cancer can also induce cardiac muscle wasting, which is associated with structural cardiac remodelling, impaired contractile function and the development of cancer-related cardiomyopathy. [...]

In this article, we outline the ongoing conceptual transition of Parkinson disease (PD) from a clinically defined syndrome to a biologically defined disorder. We synthesize recent advances in neuropathology, genetics, and biomarker research, with particular emphasis on the central role of molecular imaging within emerging biology-based frameworks. [...]