Publications database

Uro-oncology is moving toward precision medicine, driven by high-dimensional longitudinal data from imaging, pathology, molecular profiling, and follow-up. However, clinical decision-making often relies on static risk scores that cannot fully capture individual disease dynamics. [...]

Cancer is frequently accompanied by cachexia, a systemic syndrome characterized by progressive loss of skeletal muscle mass, with or without loss of fat mass. Increasing evidence indicates that cancer can also induce cardiac muscle wasting, which is associated with structural cardiac remodelling, impaired contractile function and the development of cancer-related cardiomyopathy. [...]

In this article, we outline the ongoing conceptual transition of Parkinson disease (PD) from a clinically defined syndrome to a biologically defined disorder. We synthesize recent advances in neuropathology, genetics, and biomarker research, with particular emphasis on the central role of molecular imaging within emerging biology-based frameworks. [...]

Fatigue is a common symptom of cancer patients, which can impair quality of life even years after treatment. Little is known about genetic determinants of fatigue, especially in prostate cancer (PCa). [...]

Cognitive performance prediction may help identify early cognitive decline. However, the heterogeneity of research findings impedes the identification of key predictors. [...]

Abdominal and retroperitoneal sarcomas are rare but prognostically relevant tumors that pose significant diagnostic challenges due to their size and proximity to critical anatomical structures. Cross-sectional imaging is crucial for detection, characterization, staging, and treatment planning.To present the current standards of cross-sectional imaging and to convey relevant aspects for radiological assessment based on established guidelines.Summary of the morphological characteristics, recommendations for imaging and resectability criteria based on current guidelines and published literature.Magnetic resonance imaging (MRI) and computed tomography (CT) are indispensable for the assessment of abdominal and retroperitoneal sarcomas, especially with regard to organ and vessel relationships. [...]

Copy number variants (CNVs) are strongly implicated in neurological and psychiatric disorders and brain cancer, yet the process by which replication stress generates CNVs-and why some recur while others remain rare-remains poorly understood. Here, we show that recurrent DNA-break clusters (RDCs) act as common initiating lesions that drive both recurrent and non-recurrent CNVs. [...]