Publications database

In the latest version of the World Health Organization Classification (WHO) of Central Nervous System Tumors, the terminology 'medulloepithelioma' has disappeared as a distinct tumor type in favor of 'embryonal tumor with multilayered rosettes (ETMR)', characterized by frequent alterations of C19MC. However, medulloepithelioma persists in the current WHO classification of eye tumors, where two variants exist (teratoid and non-teratoid), harboring frequent DICER1 mutations. [...]

Mitochondrial disease encompasses inherited disorders affecting mitochondrial function. A severe and untreatable form of mitochondrial disease is Leigh syndrome (LS), causing psychomotor regression and metabolic crises. [...]

Prostate-specific membrane antigen (PSMA)-PET usage in patients with prostate cancer is growing rapidly. Thus, novel risk-group definitions based on PSMA-PET are urgently needed for guidelines, clinical use, and trial study design. [...]

Retrotransposons are DNA elements capable of inserting themselves into various regions of the genome, potentially leading to genomic changes. Their expression is tightly regulated by epigenetic and environmental factors, such as DNA methylation and radiation. [...]

Colorectal cancer (CRC) is a leading cause of cancer-related deaths worldwide. The Biobanking and Biomolecular Resources European Research Infrastructure (BBMRI-ERIC) established a CRC-Cohort with European coverage contributed by 26 biobanks from 12 countries. [...]

Mono-ADP-ribosylation, a modification of both proteins and nucleic acids, is implicated in innate immunity. Intracellularly, this modification is catalyzed by PARP enzymes, some induced in response to interferons. [...]

Haematopoietic cell transplantation (HCT) with HLA-mismatched unrelated donors (MMUD) offers access to curative therapy for patients lacking well-matched donors. Accumulating evidence suggests that functional matching among allele-mismatched pairs can significantly influence patient outcomes. [...]

In 2022, the World Health Organization (WHO) classified adrenal cortical carcinoma (ACC) into four subtypes: conventional, oncocytic, myxoid, and sarcomatoid. The differences in prognosis among these subtypes remain unclear. [...]

Excessive retraction force during a minimally invasive surgery could cause tissue damage, affecting the surgical outcome. The integration of surgical force feedback relies on incorporating force sensors into the instruments, predominantly for robot-assisted surgery. [...]