Publications database

This first-in-human phase 1 study evaluated the B-cell maturation antigen (BCMA)×CD3 bispecific antibody WVT078 alone and in combination with the γ-secretase inhibitor WHG626 in patients with relapsed/refractory multiple myeloma (r/r MM).The primary objectives were to assess safety, tolerability, and to determine the recommended doses (RDs) and regimens for expansion for WVT078 and WHG626. Secondary objectives included the assessment of preliminary antitumor activity and characterization of pharmacokinetics and immunogenicity.Overall, 56 patients were treated in the dose-escalation part of the study, seven of whom experienced dose-limiting toxicities. [...]

Music therapy is a beneficial supportive intervention in oncology. However, many patients undergoing cancer treatment face treatment-related physical impairments that limit participation in in-person sessions. [...]

Mobile health (mHealth) technologies are increasingly used in paediatric oncology to promote physical activity, with growing evidence supporting their feasibility and effectiveness. Augmented reality (AR) is emerging as a promising addition, offering interactive features that may enhance participation in exercise for young people. [...]

Brain metastases (BM) from non-small cell lung cancer (NSCLC) are a relevant cause of morbidity and mortality. This study aims to identify a population at high risk for BM in order to inform personalized follow-up strategies in the future. [...]

High-dose chemotherapy followed by autologous stem cell transplantation (ASCT) remains the standard of care for fit patients with newly diagnosed multiple myeloma (MM). The increasing use of CD38 antibody-based quadruplet induction regimens such as daratumumab-VTd (Dara-VTd) has raised concerns regarding impaired stem cell mobilization.We conducted a retrospective single-center analysis comparing steady-state stem cell mobilization after Dara-VTd versus bortezomib-cyclophosphamide-dexamethasone (VCd) induction. [...]

Background: Standard of care for non-metastatic colon cancer is surgeryfollowed by stage-guided adjuvant therapy and/or structured follow-up.Upfront surgery in resectable colon cancer is irrespective of local T/Nstage, whereas adjuvant systemic therapy is recommended according topathological staging. The role of neoadjuvant chemotherapy remainsunclear. [...]

Artificial intelligence in mental health has emerged as a potent tool to foster precision psychiatry, for example, by stratifying patient populations. A potential step forward would be mental health digital twins-the independent in-silico reconstruction of an individual person within their functional social and environmental systems that continuously incorporate all known and available subject parameters to predict patient trajectories including the outcomes of interventions. [...]

Non-functional pancreatic neuroendocrine tumors (NF-pNETs) are increasingly diagnosed, particularly in older adults, largely due to widespread cross-sectional imaging. Patients with NF-pNETs typically have a soft pancreas and a small main pancreatic duct, which puts them at high risk for postoperative pancreatic fistula B/C, significantly impacting postoperative morbidity and mortality. [...]