Publications database

Our previous work has revealed that PTCH1, a Hedgehog receptor which is expressed in many aggressive cancers, plays a role in transporting chemotherapeutic drugs out of cancer cells and contributes to their resistance to chemotherapy. PTCH1 transports drugs via the proton motive force using the 'reverse pH gradient', which makes its drug efflux activity specific to cancer cells and PTCH1 a highly relevant and specific new therapeutic target for cancer treatment. [...]

Acute myeloid leukemia (AML) is an aggressive form of myeloid malignancy with high relapse and poor survival rates. Despite recent advances in genomics-based risk classification, accurate prediction of patient outcomes remains a challenge, posing the need for complementary molecular information to enable precise treatment stratification. [...]

Fibroblast activation protein inhibitor (FAPI) has demonstrated promising oncological diagnostic performance. Although no adverse events (AEs) have been previously reported, a formal safety evaluation of FAPI PET/CT is lacking. [...]

Immune checkpoint inhibitors have shown promising results in the neoadjuvant treatment of resectable non-small cell lung cancer. This open-label, single-arm, prospective, monocentric trial evaluated the efficacy and safety of neoadjuvant atezolizumab plus carboplatin/nab-paclitaxel in patients with resectable non-squamous non-small cell lung cancer. [...]

To evaluate whether nodal maximum standardised uptake value (SUVmax) improves the positive predictive value (PPV) of prostate-specific membrane antigen (PSMA) positron emission tomography (PET)/computerised tomography (CT) for detecting lymph node invasion (LNI) in prostate cancer (PCa), and to develop clinical decision tools to guide decision-making for patients with low- and high-volume nodal disease.This international multicentre study included patients with histopathologically confirmed PCa who underwent preoperative PSMA-PET and robot-assisted radical prostatectomy with extended pelvic lymph node dissection (2016-2023). Sensitivity, specificity, PPV, and negative predictive value (NPV) for LNI detection were calculated, defining a positive test as non-physiological PSMA uptake classified according to the Prostate Cancer Molecular Imaging Standardised Evaluation (PROMISE) molecular imaging Tumour-Node-Metastasis (miTNM) system. [...]

Several factors have been associated with altered risk of developing multiple sclerosis (MS). Epstein-Barr virus (EBV) is the critical risk factor for MS, but recent studies indicate that human herpesvirus 6A (HHV-6A) and cytomegalovirus (CMV) are involved in MS aetiopathogenesis. [...]

Gene expression is a multi-layered process, tightly regulated by several transcriptional and post-transcriptional mechanisms. While transcription is regulated for example by DNA methylations and chromatin modifications, the fate of RNA post-transcriptionally is modulated by RNA modifications on coding and non-coding RNAs. [...]