Publications database

The contribution of clonal hematopoiesis (CH) and disease-initiating precursors in B-cell non-Hodgkin lymphomas (B-NHLs) remains underexplored. Such precursors may drive clonal evolution, contributing to disease progression and relapse. [...]

We conducted a multicenter study on single-isocenter multitarget stereotactic radiosurgery (SIMT SRS) to dosimetrically assess end-to-end test results and identify approaches and techniques influencing spatial accuracy and treatment plan quality.An anthropomorphic head phantom with radiochromic film and polymer gel inserts was used with a reference structure set of five brain metastases. End-to-end tests were performed on-site at 23 centers in Germany, Austria, and Switzerland, each following its own SIMT SRS protocol. [...]

Desmoplastic small round cell tumor (DSRCT) is an ultra-rare sarcoma with limited treatment options. Here, we show that comprehensive molecular profiling informs diagnosis and individualized therapy in this disease. [...]

Mucosal homeostasis after birth depends on coordinated interactions between the microbiota and the immune system, with barrier tissues employing distinct mechanisms. Here, we show that maternal Immunoglobulin G (IgG), transferred both in utero and via breastfeeding, reaches the murine neonatal salivary glands and is secreted into saliva, where it recognizes maternal oral microbes and regulates colonization. [...]

Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease with a significant impact on a patient's daily life, negatively affecting numerous psychological and physical aspects. Thus, patients with HS may be at elevated risk of developing addictive disorders. [...]

The incidence of obesity and early-onset colorectal cancer (CRC) has rapidly increased in recent decades. We estimated CRC risk differences by body mass index (BMI) and derived corresponding BMI-specific CRC screening initiation ages across multiple countries, to help refine the timing of CRC prevention. [...]

This study aimed to conduct a head-to-head comparison of the diagnostic value of serum carcinoembryonic antigen (sCEA) and fecal CEA (fCEA) for colorectal cancer (CRC) detection. Fecal and serum samples from 80 CRC cases at various tumor stages and 100 controls free of colorectal neoplasms at screening colonoscopy were randomly selected from two ongoing large prospective CRC detection studies (IDA and BLITZ) for CEA measurements. [...]

International guidelines suggest prophylactic anticoagulation for patients with cancer at high risk of venous thromboembolism (VTE). Here, we evaluated whether tumor whole-genome sequencing data may improve the selection of high-risk patients.In a pan-cancer cohort of 3087 patients, associations of candidate clinical predictors, the germline extended 297-single nucleotide polymorphism polygenic risk score, tumor mutational characteristics, and somatic tumor mutations with VTE were estimated by calculating hazard ratios (HRs).During 12-month follow-up, 237 (7.7%) developed VTE. [...]

Brain organoids are exposed during their growth to fluorescent carbon nanodots (CNDs). We observe that the CNDs penetrate through the whole organoid in all maturation stages and are taken up by viable cells irrespective of their type and location, most likely by endocytosis. [...]