Publications database

The human integrin lymphocyte function-associated antigen 1 (LFA-1; αLβ2) is broadly expressed on leukocytes and involved in various intercellular adhesions. We report complete LFA-1 deficiency because of inherited αL (CD11a) deficiency in otherwise healthy adults of various ancestries with skin lesions due to commensal papillomaviruses. [...]

Combining radiotherapy (RT) with targeted agents may lead to improved treatment outcomes across various tumor types. However, there is a risk of increased toxicity. [...]

Proton beam radiotherapy (PBT) offers superior accuracy of dose deposition, reducing the risk of adverse effects to surrounding healthy tissues. However, despite high medical need, molecular and cellular determinants of radiosensitivity to proton radiotherapy remain underexplored, and prognostic biomarkers and therapeutic targets informing precision medicine strategies for PBT are mostly missing. [...]

Prostate cancer (PC) is increasingly treated with curative intent, making health-related quality of life (HRQOL) a key outcome. This prospective study evaluated the EQ-5D-5L instrument based HRQOL trajectories in PC patients undergoing radiotherapy (RT) to assess the instrument's responsiveness, determine meaningful changes, and strengthen the evidence on patient-centered outcomes in routine care.A total of 262 patients undergoing curative RT were prospectively assessed using the EQ-5D-5L questionnaire at baseline, treatment completion, and final follow-up. [...]

Anaplastic thyroid cancer (ATC) is a highly aggressive malignancy associated with a limited prognosis. Recent advances in targeted therapies and improved systemic therapy options have led to an increasing number of patients experiencing isolated or limited metastatic progression. [...]

Robot-assisted partial nephrectomy (RAPN) is increasingly used to treat renal cell carcinoma (RCC), but randomized data comparing long-term outcomes to those after open partial nephrectomy (OPN) remain limited. Our aim was to compare oncological, renal function, and health-related quality of life (HRQOL) outcomes at 2 yr for patients who underwent RAPN versus OPN.This single-center phase 2 randomized controlled trial included 50 patients with suspected localized RCC who were randomized 1:1 to RAPN or OPN. [...]

Heightened sterile inflammation and mitochondrial metabolic dysfunction drives the pathophysiology of heart failure in ischemic cardiomyopathy. Yet, the transcriptional regulators within cardiomyocytes driving crosstalk between inflammation and energy metabolism remain ill-defined. [...]

CAR-T cell therapy is effective in hematologic malignancies but remains challenging in solid tumors owing to antigen heterogeneity and tumor microenvironment-induced exhaustion. Here, gene editing of the nuclear receptor NR2F6 restores CAR-T cell functionality, sustaining a TCF1⁺ progenitor-exhausted phenotype, enhancing metabolic fitness, and preserving cytotoxic potency under chronic antigen exposure. [...]

Purpose: Glioblastoma, IDH-wildtype is a highly aggressive and often recurrent brain malignancy characterized by a profoundly immunosuppressive and heterogeneous tumor microenvironment. In this study, we aimed to systematically comparecommonly used immune profiling methodologies.Methods: We conducted a cross-platform comparison using matched primary and recurrent tumor samples analyzed byimmunohistochemistry, multiplex immunofluorescence, AI-driven image analysis, DNA methylation profiling, and bulkRNA sequencing. [...]