Publications database

Accurate cancer staging is essential for cancer research and treatment evaluation; however, real-world data (RWD) often include incomplete or inconsistent UICC classifications. We present the development, optimization, demonstration, and release of the Munich UICC Staging Tool (MUST), an open-source R script that automates UICC staging based on TNM classifications and tumor characteristics, improving data completeness and consistency. [...]

This updated clinical practice guideline provides a practical, evidence-based approach for the management of adult soft tissue sarcoma of the extremity and trunk wall.The European Society for Radiotherapy and Oncology (ESTRO) formed a task force of 13 European experts, alongside 3 experts from the American Society for Radiation Oncology (ASTRO), to analyze current evidence, give recommendations and establish expert consensus in areas lacking strong evidence. Thirteen key questions were identified, encompassing indications for radiotherapy, pre- vs. [...]

Low Ki67 after short preoperative endocrine treatment (ET) indicates a favorable prognosis in HR+/HER2- early breast cancer (eBC). We investigated predictors of ET-response in the WSG ADAPT-HR+/HER2- and ADAPTcycle trials.ET-response (Ki67 ≤10%) after 2-4-week standard ET, recurrence score (RS), and nodal status were used for treatment allocation. [...]

Primary sclerosing cholangitis (PSC) has a variable disease course, complicating patient counseling and timing of liver transplantation. Vitamin B6 deficiency predicts reduced liver transplantation-free survival in Scandinavian PSC cohorts. [...]

Some aggressive cancers exhibit a level of rapid genome change and therapy resistance that is difficult to explain. Research over the past decade has shown that extrachromosomal DNA (ecDNA) can be the cause. [...]

Both the nervous system and cancer-intrinsic neural features can govern cancer initiation, growth, progression, metastasis, and treatment resistance, while cancer can likewise influence the nervous system, promoting neural reprogramming and neuropsychiatric symptoms that worsen patient outcomes. The field of cancer neuroscience seeks to unravel this complex neuro-cancer crosstalk and holds the promise to develop neuroscience-instructed cancer therapies that improve disease control and quality of life. [...]