Publications database

Immunotherapy has revolutionized the treatment of solid cancers in recent years. However, T-cell lymphomas (T-NHLs) originate from immune cells themselves and are biologically heterogeneous, rendering investigations of immune checkpoint inhibitor (ICI) mechanisms of action complex. [...]

One-carbon metabolism (1CM) regulates critical processes to carcinogenesis. However, the influence of 1CM-related nutritional and genetic factors on breast cancer (BC) risk remains unclear.To assess the impact of 1CM-related nutrients and genetic variants with BC risk.Case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, including 3067 incident BC cases and 3067 matched controls from seven European countries. [...]

Reactive carbonyl species contribute to diabetes and its complications, but how the interconnections of carbonyl-detoxifying enzymes regulate metabolic homeostasis through arginine metabolism remains unclear. Here we generate zebrafish lacking both glyoxalase 1 and aldo-keto reductase 1A1A, two major enzymes that detoxify methylglyoxal and acrolein. [...]

Flexible cystoscopy is integral to outpatient urology, particularly for surveillance of non-muscle-invasive bladder cancer. Real-world economic data comparing reusable (RU) and single-use (SU) cystoscopes in German outpatient practice are scarce. [...]

WHO grade 2 meningiomas exhibit highly heterogeneous clinical courses. While the Ki67 proliferation index is a standard biomarker, its prognostic utility remains limited by methodological inconsistency and potential time-dependent dynamics. [...]

BACKGROUND Cholangiocarcinoma (CCA) is a biologically heterogeneous and aggressive biliary malignancy associated with poor survival outcomes despite surgical resection. Germline genetic variants, including single-nucleotide polymorphisms (SNPs), may modulate tumor behavior and inform postoperative risk stratification. [...]