Publications database

Most patients with relapsed or refractory multiple myeloma (RRMM) have previously received lenalidomide (LEN) and proteasome inhibitors (PIs). This real-world study describes treatment patterns and clinical outcomes for RRMM patients post-LEN and PI in Germany.The BasecaMMp cohort included patients with prior LEN and PI therapy within the first to third line of treatment (LOT) between May 2016 and December 2023. [...]

Large-scale perturbational approaches have transformed cancer research, enabling systematic identification of tumour-specific dependencies and therapeutic vulnerabilities. However, many clinically relevant vulnerabilities arise from genetic interactions, including synthetic lethal and buffering relationships, and are shaped by cellular state, lineage and treatment history. [...]

Over recent years, several deep learning (DL) models have been presented to predict colorectal cancer (CRC) patient survival directly from haematoxylin and eosin (H&E)-stained routine whole-slide images (WSIs). Unlike traditional studies that rely on manually defined histopathological features, weakly supervised DL allows training directly on clinical endpoints without prior specification of the model's focus. [...]

Chemotherapy is typically administered prior to consideration of tandem [225Ac]Ac-/[177Lu]Lu-PSMA-617 therapy in metastatic castration-resistant prostate cancer (mCRPC), making chemotherapy-naïve patients who undergo tandem radionuclide treatment extremely rare. The genomic mechanisms dictating response and resistance to prostate-specific membrane antigen-radiopharmaceutical therapy (PSMA-RPT) in this setting remain unclear. [...]

Osteoradionecrosis (ORN) following head and neck radiotherapy has been demonstrated to induce structural and functional alterations of the upper airway, with the potential to complicate the process of tracheal intubation. Despite its clinical relevance, there is a paucity of systematic evidence on airway characteristics in ORN and reliable predictors of difficult tracheal intubation. [...]

Melanoma of unknown primary accounts for up to 10% of all metastatic melanoma patients. The origin of melanoma of unknown primary is unclear, and previous studies on the clinical course in comparison to cutaneous melanoma have reported different results.The study was conducted to assess the oncogenic pattern of melanoma of unknown primaries (MUP) and compare clinical course with melanoma of known cutaneous primary (MKP).MUP patients diagnosed between 1999 and 2022 were included in this cohort study from the prospective multicentre real-word DeCOG registry ADOREG and from the tumour database of the University Hospital Essen. [...]

Vitamin D insufficiency and deficiency are common worldwide and linked to adverse health outcomes, including higher all-cause mortality. Two large randomized controlled trials (VITAL and D-Health), conducted in mostly vitamin D-sufficient populations, found no mortality benefits of vitamin D supplementation. [...]

Radiation-induced pneumonitis (RP) is a side effect after thoracic radiotherapy (RT). The ability to predict RP would facilitate treatment modifications. [...]