Publications database

We report an 81-year-old man with metastatic castration-resistant prostate cancer (mCRPC) after multiple prior therapies, including androgen deprivation therapy (ADT), the androgen receptor pathway inhibitor (ARPI) abiraterone, taxane chemotherapy with docetaxel and cabazitaxel, radiopharmaceutical therapy (RPT) with 4 cycles of [177Lu]PSMA-I&T, and the PARP inhibitor olaparib in combination with abiraterone. Due to biochemical and clinical progression, [18F]PSMA-1007 PET/CT was performed for restaging, revealing diffuse skeletal metastases without significant extraosseous disease. [...]

Metastatic cancers of unknown primary (CUP) pose significant diagnostic and therapeutic challenges. We present the case of a 63-year old male patient with a CUP showing neuroendocrine differentiation, metastasized to the iliac bone, bone marrow, supraclavicular and retroperitoneal lymph nodes. [...]

Rapid vascular recovery is a key feature preceding glioblastoma (GBM) recurrence after radiotherapy (RT). We performed spatial expression analyses, providing a rationale for dual inhibition of two non-redundant, spatially distinct acting factors, CXCL12 and VEGF. [...]

Model systems that mimic human cardiac structure and function are essential for the development of novel diagnostics and effective treatments for cardiovascular diseases. While non-human vertebrate models, from zebrafish to pig, remain vital to cardiovascular research, the translatability of findings to human patients is often limited. [...]

Since the inception of spinal radiosurgery decades ago, the factors influencing spinal cord recovery have remained unclear. Elucidating these factors would aid in reirradiation planning and delivery. [...]

The disparity in maternal mortality and severe morbidity between high- and low-income countries is well established. Previously, we highlighted within-country disparities in Ethiopia using demographic and health survey data. [...]

Questionnaires assessing symptoms in chronic obstructive pulmonary disease (COPD) rely on retrospective reporting, introducing recall bias and missing symptom variability. Ecological momentary assessment (EMA) addresses these limitations by capturing real-time symptom data.The aim of this study was to compare EMA symptom ratings with traditional questionnaires in patients with COPD.A subsample from the FAntasTIGUE study rated symptoms using questionnaires (visual analog scale, modified Medical Research Council Dyspnea Scale, Physical Activity Rating Scale-Dyspnea Questionnaire, Checklist Individual Strength-subscale Subjective Fatigue, Hospital Anxiety and Depression Scale, and COPD Assessment Test) and EMA. [...]