Publications database

Latest additions:
2023-02-07
15:43
[DKFZ-2023-00298] Journal Article
; ; ; et al
A Pro-Regenerative Environment Triggers Premalignant to Malignant Transformation of Senescent Hepatocytes.
Cancer research 83(3), 428 - 440 () [10.1158/0008-5472.CAN-22-1477]  GO
Unfortunately, available liver cancer treatments are associated with modest survival advantage. The biggest factor improving survival is early detection, but the current understanding of early transformation events is limited. [...]

Detailed record - Similar records
2023-02-07
15:42
pmc [DKFZ-2023-00297] Journal Article
; ; ; et al
Physical activity and breast cancer survival: results from the Nurses' Health Studies.
Physical activity is generally associated with better outcomes following diagnosis; however, few studies have evaluated change in pre- to postdiagnosis activity and repeated measures of activity by intensity and type.We evaluated physical activity and survival following a breast cancer diagnosis in the Nurses' Health Study and Nurses' Health Study II (n = 9308 women, n = 1973 deaths). Physical activity was evaluated as updated cumulative average of metabolic equivalent of task (MET)-h/wk (assigned per activity based on duration and intensity) and change in pre- to postdiagnosis activity. [...]

Detailed record - Similar records
2023-02-07
15:40

Detailed record - Similar records
2023-02-07
15:37
pmc [DKFZ-2023-00295] Journal Article
; ; ; et al
Staining of activated ß2-integrins in combination with CD137 and CD154 for sensitive identification of functional antigen-specific CD4+ and CD8+ T cells.
Common flow cytometry-based methods used for functional assessment of antigen-specific T cells rely on de novo expression of intracellular cytokines or cell surface activation induced markers. They come with some limitations such as complex experimental setting, loss of cell viability and often high unspecific background which impairs assay sensitivity. [...]

Detailed record - Similar records
2023-02-07
15:36
DBCoverage [DKFZ-2023-00294] Journal Article (Review Article)
; ;
Cholesterol metabolism in the regulation of inflammatory responses.
The importance of biologically active lipid mediators, such as prostanoids, leukotrienes, and specialized pro-resolving mediators, in the regulation of inflammation is well established. While the relevance of cholesterol in the context of atherosclerosis is also widely accepted, the role of cholesterol and its biosynthetic precursors on inflammatory processes is less comprehensively described. [...]

Detailed record - Similar records
2023-02-07
15:34
[DKFZ-2023-00293] Journal Article
; ; ; et al
The mechanosensitive TRPV2 calcium channel promotes human melanoma invasiveness and metastatic potential.
Melanoma is a highly aggressive cancer endowed with a unique capacity of rapidly metastasizing, which is fundamentally driven by aberrant cell motility behaviors. Discovering 'migrastatics' targets, specifically controlling invasion and dissemination of melanoma cells during metastasis, is therefore of primary importance. [...]

Detailed record - Similar records
2023-02-07
15:33
DBCoverage [DKFZ-2023-00292] Journal Article (Review Article)
; ; ; et al
The significance of margins in pediatric Non-Rhabdomyosarcoma soft tissue sarcomas: Consensus on surgical margin definition harmonization from the INternational Soft Tissue SaRcoma ConsorTium (INSTRuCT).
Margin status following surgery in children, adolescents, and young adults with soft tissue sarcomas is controversial and has been defined differently by various specialties, with definitions changing over time and by cooperative group. The International Soft Tissue Sarcoma Consortium (INSTRuCT) is a collaboration of the Children's Oncology Group (COG) Soft Tissue Sarcoma Committee, European pediatric Soft Tissue sarcoma Study Group (EpSSG), and the European Cooperative Weichteilsarkom Studiengruppe (CWS) devoted to improving patient outcomes by pooling and mining cooperative group clinical trial data.The INSTRuCT non-rhabdomyosarcoma soft tissue sarcoma (NRSTS) working group aimed to develop international harmonized recommendations regarding surgical margin assessment and definitions in children and adolescents with soft tissue tumors.This review addresses accepted principles and areas of controversy, including the perspectives of surgeons, pathologists, radiation oncologists, and pediatric oncologists, to develop a framework for building common guidelines for future research..

Detailed record - Similar records
2023-02-07
15:21
DBCoverage [DKFZ-2023-00291] Journal Article (Review Article)
; ; ; et al
A unified classification approach rating clinical utility of protein biomarkers across neurologic diseases.
A major evolution from purely clinical diagnoses to biomarker supported clinical diagnosing has been occurring over the past years in neurology. High-throughput methods, such as next-generation sequencing and mass spectrometry-based proteomics along with improved neuroimaging methods, are accelerating this development. [...]

Detailed record - Similar records
2023-02-07
15:19
[DKFZ-2023-00290] Journal Article
; ; ; et al
DGN-Handlungsempfehlung (S1-Leitlinie) – PSMA-Liganden-PET/CT in der Diagnostik des Prostatakarzinoms – Stand: 01/2022 – AWMF-Registernummer: 031-055.
Nuklearmedizin 62(1), 5 - 19 () [10.1055/a-1984-8167]  GO
PSMA-PET/CT for imaging prostate cancer (PC) has spread worldwide since its clinical introduction in 2011. The majority of experiences have been collected for PSMA-PET-imaging of recurrent PC. [...]

Detailed record - Similar records
2023-02-07
15:15

Detailed record - Similar records