2023-02-07 15:43 |
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2023-02-07 15:42 |
[DKFZ-2023-00297]
Journal Article
Turzanski-Fortner, R. ; Brantley, K. D. ; Tworoger, S. S. ; et al
Physical activity and breast cancer survival: results from the Nurses' Health Studies.
Physical activity is generally associated with better outcomes following diagnosis; however, few studies have evaluated change in pre- to postdiagnosis activity and repeated measures of activity by intensity and type.We evaluated physical activity and survival following a breast cancer diagnosis in the Nurses' Health Study and Nurses' Health Study II (n = 9308 women, n = 1973 deaths). Physical activity was evaluated as updated cumulative average of metabolic equivalent of task (MET)-h/wk (assigned per activity based on duration and intensity) and change in pre- to postdiagnosis activity. [...]
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2023-02-07 15:40 |
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2023-02-07 15:37 |
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2023-02-07 15:36 |
[DKFZ-2023-00294]
Journal Article (Review Article)
Bauer, R. ; Brüne, B. ; Schmid, T.
Cholesterol metabolism in the regulation of inflammatory responses.
The importance of biologically active lipid mediators, such as prostanoids, leukotrienes, and specialized pro-resolving mediators, in the regulation of inflammation is well established. While the relevance of cholesterol in the context of atherosclerosis is also widely accepted, the role of cholesterol and its biosynthetic precursors on inflammatory processes is less comprehensively described. [...]
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2023-02-07 15:34 |
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2023-02-07 15:33 |
[DKFZ-2023-00292]
Journal Article (Review Article)
Sparber-Sauer, M. ; Ferrari, A. ; Spunt, S. L. ; et al
The significance of margins in pediatric Non-Rhabdomyosarcoma soft tissue sarcomas: Consensus on surgical margin definition harmonization from the INternational Soft Tissue SaRcoma ConsorTium (INSTRuCT).
Margin status following surgery in children, adolescents, and young adults with soft tissue sarcomas is controversial and has been defined differently by various specialties, with definitions changing over time and by cooperative group. The International Soft Tissue Sarcoma Consortium (INSTRuCT) is a collaboration of the Children's Oncology Group (COG) Soft Tissue Sarcoma Committee, European pediatric Soft Tissue sarcoma Study Group (EpSSG), and the European Cooperative Weichteilsarkom Studiengruppe (CWS) devoted to improving patient outcomes by pooling and mining cooperative group clinical trial data.The INSTRuCT non-rhabdomyosarcoma soft tissue sarcoma (NRSTS) working group aimed to develop international harmonized recommendations regarding surgical margin assessment and definitions in children and adolescents with soft tissue tumors.This review addresses accepted principles and areas of controversy, including the perspectives of surgeons, pathologists, radiation oncologists, and pediatric oncologists, to develop a framework for building common guidelines for future research..
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2023-02-07 15:21 |
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2023-02-07 15:19 |
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2023-02-07 15:15 |
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