Publications database

Outcomes for children with relapsed and refractory neuroblastoma are dismal. ENCIT-01 (NCT02311621) was a first-in-human clinical trial for patients with relapsed and refractory neuroblastoma using chimeric antigen receptor (CAR) T cells targeting L1CAM, an adhesion molecule that is overexpressed in neuroblastoma with limited normal tissue expression.This trial evaluated three different CAR constructs: a short-spacer second-generation 4-1BB CAR (2GS, arm A), a short-spacer third-generation 4-1BB + CD28 CAR (3GS, arm B), and a long-spacer second-generation 4-1BB CAR (2GL, arm C).Thirty-six patients were enrolled, of whom 22 were treated (arm A/2GS n = 11, arm B/3GS n = 8, and arm C/2GL n = 3). [...]

Objective.Range uncertainties in proton therapy largely arise from the semi-empirical conversion of x-ray computed tomography (CT) Hounsfield Units to stopping power relative to water (RSP), requiring generous safety margins or robust optimization. Pencil beam-wise integrated depth-dose profiles (IDDs), obtained via proton transmission imaging using a particle integrating detector, can be combined with the treatment planning CT to obtain patient-specific conversion curves. [...]

Soluble variants of recombinant T cell receptors (TCRs) have become attractive tools for the retargeting of cytotoxic T cells toward intracellular tumor or viral antigens by combining them with CD3-binding antibodies in bispecific T cell engagers; however, TCR-based NK cell engagers have not been studied so far. Here, we developed TCR-based bispecific agents for the redirection of NK cells utilizing a bivalent IgG1-like format. [...]

Chronic lymphocytic leukemia (CLL) exhibits marked clinical heterogeneity that cannot be fully explained by genetic alterations, underscoring the critical role of the tumor microenvironment in disease progression and therapeutic resistance. To delineate the temporal evolution of immune dysregulation in CLL, we used the Eµ-TCL1 adoptive transfer (TCL1-AT) mouse model combined with high-dimensional spectral flow cytometry to longitudinally profile lymphoid and myeloid compartments. [...]

DNA methylation-based tumor classification has become an essential tool in neuropathological diagnostics, yet a subset of central nervous system (CNS) tumors remains unclassifiable using current approaches. The performance of machine learning-based classifiers across varying case complexity is not fully defined. [...]

Adolescent cancer survivors (ACS) often have persistent impairments in muscle strength, physical function, and quality of life (QoL). This study investigates the efficacy of strength training compared with low-load circuit training in increasing muscle strength over 16 weeks among ACS.In this superiority randomized controlled trial (NCT06299722), 46 ACS aged 10-19 years were randomized 1:1 to (1) high-load progressive strength training (STEEL) targeting major muscle groups, or (2) circuit training with aerobic and strength components. [...]

Monitoring therapy response in pancreatic cancer (PDAC) remains challenging. The microbiome affects therapy efficacy, but its role in response prediction is unclear. [...]

Programmed ribosomal frameshifting (PRF) is a conserved viral strategy for expressing polyproteins from compact genomes. Although PRF is traditionally viewed as a structural mechanism, here we show that it functions as a regulatory signal that rewires host translation in favor of viral replication. [...]

Research on healthy lifestyles across various cancers is limited. We conducted a pan-cancer analysis to evaluate the associations of healthy lifestyle with cancer risk.Data from 287,745 UK Biobank participants were analysed. [...]