Publications database

Frameless linear accelerator (linac)-based image-guided stereotactic radiosurgery (SRS) or fractionated stereotactic radiotherapy (FSRT) are a widely used treatment option for intracranial lesions. Given the high radiation doses involved, it is crucial to maintain precise patient positioning throughout treatment. [...]

Thyroid angiosarcomas (TAS) are listed as a distinct entity in the WHO classification of malignant tumors and represent highly aggressive neoplasms with early metastasis and overall survival of few months. Owing to their rarity, data on tumorigenesis, molecular alterations, and potential therapeutic targets remain limited. [...]

Background:Cutaneous melanoma is the most aggressive type of skin cancer, with survival rates declining due to tumor heterogeneity and therapy resistance. Distinct subpopulations, including slow-cycling, therapy-resistant cells with high expression of the histone demethylase KDM5B, contribute to tumor progression and poor outcomes. [...]

Background:Natural killer (NK) cells are at the forefront of the fight against infections and cancer, where they recognize targets through a system of inhibitory and activating ligands expressed on monitored cells. The transcriptional regulation of such ligands in tumors remains poorly understood. [...]

ALK and ROS1 fusions are key drivers of infant-type hemispheric gliomas (IHG). With diverse gene partners, the impact of ALK and ROS1 oncoprotein heterogeneity on glioma biology remains unknown. [...]

Pineoblastoma is a clinically aggressive childhood brain tumor composed of distinct molecular subgroups with divergent driver genes, demographics, and clinical outcomes. To identify developmental origins and mechanisms governing disease pathogenesis, we derive single-cell transcriptomes from pineal parenchymal tumors, aligning malignant cells with developmental counterparts to retrace cellular origins. [...]

Despite significant progress in identifying risk factors for colorectal cancer (CRC), factors influencing survival in people with CRC remain less understood. Pro-inflammatory cytokines like interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) have been implicated in cancer progression and may influence CRC outcomes. [...]

Parkinson's disease is the second most common neurodegenerative disorder, with environmental factors influencing the risk. The role of dairy consumption is controversial, despite repeated with Parkinson's disease in epidemiological studies.We conducted a systematic review and meta-analysis to evaluate sex-specific associations between dairy intake and Parkinson's disease risk.A literature search was performed using the Medline and EMBASE databases. [...]