Publications database

Radiopharmaceuticals offer targeted treatment by combining diagnostic or therapeutic radionuclides with biologically active molecules. Auranofin is the only Food and Drug Administration (FDA) approved gold(I) complex, originally developed for the treatment of rheumatoid arthritis. [...]

Self-renewal and differentiation are at the basis of hematopoiesis. While it is known that tight regulation of translation is vital for hematopoietic stem cells' (HSCs) biology, the mechanisms underlying translation regulation across the hematopoietic system remain obscure. [...]

In childhood brain tumors, minimizing long-term side effects of cancer therapy is a critical objective. Radiation-related imaging changes (ICs), indicative of potential radionecrosis, remain an area of active investigation in proton beam therapy (PBT). [...]

Synovial Sarcoma (SS) is driven by the SS18::SSX fusion oncoprotein and is ultimately refractory to therapeutic approaches. SS18::SSX alters ATP-dependent chromatin remodeling BAF (mammalian SWI/SNF) complexes, leading to the degradation of canonical (cBAF) complexes and amplified expression of SS18::SSX-containing non-canonical BAF (ncBAF or GBAF) complexes that drive an SS-specific transcription program and tumorigenesis. [...]

Ferroptosis has emerged as an actionable target to eliminate therapy-resistant and metastatic cancers1. However, which ferroptosis surveillance systems may offer a therapeutic window to leverage redox maladaptation in cancer remains unclear. [...]

Prostate-specific membrane antigen (PSMA) positron emission tomography (PET) computed tomography (CT), and whole-body magnetic resonance imaging (WB-MRI) are superior to conventional CT and bone scan imaging for detecting metastatic disease in patients with prostate cancer. While these higher-accuracy imaging methods have already shown the potential to enhance patient outcomes, a thorough understanding of the relationship between the treatment landscape and disease volume on conventional imaging, as well as the prognostic significance of the prostate-specific antigen response, is crucial for determining how they can be more effectively incorporated. [...]

To apply quantitative imaging analysis for noninvasive classification of the most frequent subtypes of Non-Hodgkin Lymphoma (NHL) as a basis for a clinical imaging genomic model to support therapeutic monitoring and clinical decision making.In this single-center study, 201 treatment-naïve patients with biopsy-proven NHL (50 diffuse large B-cell lymphoma [DLBCL], 51 mantle cell lymphoma [MCL], 49 follicular lymphoma [FL], and 51 chronic lymphocytic leukemia [CLL]) and 39 treatment-naïve non-small cell lung cancer patients with positron emission tomography (PET)/computed tomography (CT)-confirmed healthy axillary lymph nodes (LNs) were retrospectively analyzed. Three-dimensional (3D) segmentation and radiomic analysis of pathologically enlarged nodes (n = 1,628) were performed on contrast-enhanced CT scans, including healthy LNs as references. [...]

Asbestos is a well-established occupational carcinogen, with strong evidence linking its exposure to lung cancer. Despite increasing awareness of its health risks, asbestos continues to be used in many countries. [...]

In magnetic resonance imaging (MRI)-guided online adaptive radiotherapy, MRI lacks tissue attenuation information necessary for accurate dose calculations. Although deep learning (DL)-based synthetic computed tomography (CT) generation models have been developed to obtain CT density information from MRI, they usually do not meet the requirement of real-time plan adaptation.We propose a DL-based photon dose calculation method directly on 0.35 T MRI to skip synthetic CT generation and show its feasibility for prostate patient cases.The 0.35 T planning MRI and deformed planning CT (registered to the planning MRI) of 34 prostate cancer patients treated with a 0.35 T magnetic resonance-linear accelerator (MR-Linac) were collected. [...]

New data indicate an increased risk of obstetric complications after Covid-19, the aim of this study was therefore to investigate the expression of immune checkpoint molecules TIM-3 and Gal-9 in tissue sections of placenta from patients with acute Covid-19, from patients after Covid-19 infection and from healthy controls. We used a total of 60 placentas from women who had given birth to female or male children at Augsburg University Hospital, Germany. [...]