Publications database

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2026-02-20
09:24
DBCoverage [DKFZ-2026-00401] Journal Article
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Get strong to fight childhood cancer - an exercise intervention for children and adolescents undergoing anti-cancer treatment (FORTEe): Rationale and design of a randomized controlled exercise trial.
BMC cancer 25(1), 1275 () [10.1186/s12885-025-14489-y]  GO
Despite substantial advances in treatment, children and adolescents with cancer continue to face high morbidity and health issues, including cancer-related fatigue, treatment-related complications, and physical inactivity. Integrating exercise into pediatric oncology care has emerged as a promising approach to mitigate these burdens during cancer treatment. [...]

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2026-02-20
09:21
[DKFZ-2026-00400] Journal Article
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Assessing the Transferability of Peer-Assisted Ultrasound Training for Medical Students: A Comparative Study Between Two Institutions in Germany and the UK.
Ultrasound (US) is a clinically important imaging modality that can also enhance medical students' understanding of anatomy, physiology, and pathology. However, its integration into preclinical curricula often remains limited due to challenges such as resource constraints and instructor availability. [...]

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2026-02-20
09:18
[DKFZ-2026-00399] Journal Article (Review Article)
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Needs and health-related quality of life domains relevant to people in Europe with advanced cancer in need of palliative care: a systematic review of qualitative research.
There is a need for a comprehensive summary of qualitative research on the health-related quality of life (HRQoL) of people with advanced cancer requiring palliative care. We aim to systematically review qualitative studies on outcomes, needs, experiences, preferences, concerns and HRQoL of people in Europe with advanced cancer requiring palliative care over the last decade.Protocol registered ( www.crd.york.ac.uk/PROSPERO , CRD42024575065). [...]

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2026-02-20
09:15
[DKFZ-2026-00398] Journal Article
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Temporal and spatial composition of the tumor microenvironment predicts response to immune checkpoint inhibition in metastatic TNBC.
Immune checkpoint inhibition (ICI) benefits only a subset of patients with metastatic triple-negative breast cancer and determinants of response remain unclear. We assembled a longitudinal cohort of 103 female patients from the phase 2 TONIC trial, with samples spanning primary tumors, pretreatment metastases and on-treatment metastases during nivolumab therapy. [...]

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2026-02-20
09:05

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2026-02-19
15:27
[DKFZ-2026-00396] Journal Article
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Oxaliplatin-induced neuropathy after total neoadjuvant therapy for rectal cancer: Dose-response relationship and impact on quality of life.
Oxaliplatin-based regimens are increasingly used in total neoadjuvant therapy (TNT) for locally advanced rectal cancer, frequently causing dose-limiting chemotherapy-induced peripheral neuropathy (CIPN), whose extent and impact on health-related quality of life (HrQoL) remain insufficiently characterized. The optimal duration and intensity of chemotherapy within TNT for tumor response and toxicity remain unclear. [...]

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2026-02-19
15:23
DBCoverage [DKFZ-2026-00395] Journal Article
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GPX4 Inhibitor Resistance and Metastatic Features in Triple-Negative Breast Cancer.
Leveraging ferroptosis as a cancer therapy has faced challenges due to the limited bioavailability and systemic toxicities of small-molecule ferroptosis modulators. Small molecule inhibitors such as RSL3 and ML210 trigger ferroptosis by targeting glutathione peroxidase 4 (GPX4), a key enzyme that neutralizes lipid peroxides. [...]

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2026-02-19
15:03
DBCoverage [DKFZ-2026-00394] Journal Article
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Long-term patient experience with online MR-guided radiotherapy: adaptive versus non-adaptive workflow.
Magnetic resonance-linear accelerator (MR-Linac) systems enable high-precision radiotherapy through real-time MR guidance and daily online adaptive treatment planning. While online adaptation offers substantial dosimetric advantages, it extends treatment session durations on an already resource-intensive platform. [...]

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2026-02-19
14:59
[DKFZ-2026-00393] Journal Article
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Individualized mRNA vaccines evoke durable T cell immunity in adjuvant TNBC.
Triple-negative breast cancer (TNBC) is frequently associated with metastatic relapse, even at an early stage1. Here we assessed an individualized neoantigen mRNA vaccine in 14 patients with TNBC following surgery and after neoadjuvant or adjuvant therapy. [...]

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2026-02-19
14:57
DBCoverage [DKFZ-2026-00392] Journal Article
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Benchmarking large language model-based agent systems for clinical decision tasks.
Agentic artificial intelligence (AI) systems, designed to autonomously reason, plan, and invoke tools, have shown promise in healthcare, yet systematic benchmarking of their real-world performance remains limited. In this study, we evaluate two such systems: the open-source OpenManus, built on Meta's Llama-4 and extended with medically customized agents; and Manus, a proprietary agent system employing a multistep planner-executor-verifier architecture. [...]

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