Publications database

Accurate prediction of risk of progression from smoldering multiple myeloma (SMM) to active multiple myeloma (MM) is paramount to individualized early therapeutic strategies with minimum risk of overtreatment. Current risk stratification models do not account for evolving biomarker trajectories. [...]

Dermoscopy is a standard of care for melanoma diagnostics, and artificial intelligence (AI) systems are increasingly investigated as decision-support tools. Prospective evidence is essential to assess their performance compared to dermatologists.To evaluate the diagnostic performance of dermatologists, AI systems, and dermatologists assisted by AI in prospective studies of melanoma detection, and to assess the readiness of AI for clinical use.PubMed, Embase, Web of Science, and Google Scholar were searched from inception through July 9, 2025.Eligible studies were prospective, used dermoscopic images, and reported or allowed calculation of performance metrics for dermatologists, AI, or dermatologists assisted by AI against a histopathologic reference standard. [...]

Obesity is a growing global health concern. Some evidence suggests that exposure to polychlorinated biphenyls (PCBs) and dioxins, may play a role in weight gain, but human prospective data are limited and have shown inconsistent results. [...]

The role of oxygen in 'Ultra-High Dose Rate' (UHDR) radiotherapy is currently subject to active debate, due to its importance in the FLASH effect. Radiochemical oxygen depletion (ROD) is used to characterize the removal of oxygen by its interaction with the free radicals produced by the radiation. [...]

This first-in-human phase 1 study evaluated the B-cell maturation antigen (BCMA)×CD3 bispecific antibody WVT078 alone and in combination with the γ-secretase inhibitor WHG626 in patients with relapsed/refractory multiple myeloma (r/r MM).The primary objectives were to assess safety, tolerability, and to determine the recommended doses (RDs) and regimens for expansion for WVT078 and WHG626. Secondary objectives included the assessment of preliminary antitumor activity and characterization of pharmacokinetics and immunogenicity.Overall, 56 patients were treated in the dose-escalation part of the study, seven of whom experienced dose-limiting toxicities. [...]

Music therapy is a beneficial supportive intervention in oncology. However, many patients undergoing cancer treatment face treatment-related physical impairments that limit participation in in-person sessions. [...]

Mobile health (mHealth) technologies are increasingly used in paediatric oncology to promote physical activity, with growing evidence supporting their feasibility and effectiveness. Augmented reality (AR) is emerging as a promising addition, offering interactive features that may enhance participation in exercise for young people. [...]

Brain metastases (BM) from non-small cell lung cancer (NSCLC) are a relevant cause of morbidity and mortality. This study aims to identify a population at high risk for BM in order to inform personalized follow-up strategies in the future. [...]