Publications database

Previous studies have revealed four distinct epigenetic consensus pineoblastoma (PB) subtypes. The aim of this study was to confirm and further extend their respective genetic underpinnings. [...]

Lymphocytic choriomeningitis virus (LCMV) is a neglected zoonotic arenavirus primarily transmitted by house mice (Mus musculus). In humans, LCMV infection can cause encephalitis, meningitis, or severe birth defects. [...]

First-line cancer treatment frequently fails due to initially rare therapeutic resistance. An important clinical question is then how to schedule subsequent treatments to maximize the probability of tumour eradication. [...]

Acute myeloid leukemia (AML) is characterized by frequent relapse, which is driven by resistant leukemic stem or progenitor cells (LSCs). Here, we reported on a tumor-suppressive mechanism that can be harnessed to simultaneously clear LSCs and promote healthy hematopoiesis. [...]

Panel sequencing, whole-exome sequencing (WES) and whole-genome sequencing (WGS) often uncover therapeutic targets for cancer patients. However, it is still largely unclear to what extent patients directly benefit from broader analyses over panel sequencing alone.We analyzed the molecular findings and recommendations issued by our molecular tumor board (MTB) in a cohort of patients who had received both a well-established diagnostic panel of medium size (up to 203 genes) and in-house WES, focusing on the number of recommendations that were issued on the basis of WES results only.Our cohort consisted of 38 patients with advanced cancers, of whom about two-thirds had common and one-third had rare cancers. [...]

Targeted protein degradation is a pharmacological strategy that relies on small molecules such as proteolysis-targeting chimeras (PROTACs) or molecular glues, which induce proximity between a target protein and an E3 ubiquitin ligase to prompt target ubiquitination and proteasomal degradation1. Sporadic reports indicated that ligands designed to inhibit a target can also induce its destabilization2-4. [...]

Einleitung In den letzten Jahren ist die altersstandardisierte Krebsinzidenz in Deutschland für viele Krebsarten zurückgegangen. Inwiefern sich diese Entwicklung auf regionaler Ebene im Hinblick auf sozioökonomische Ungleichheiten bei der Krebsinzidenz unterscheidet, ist jedoch unbekannt [...]