Publications database

Immunodeficiency-associated primary CNS lymphoma (ID-PCNSL) represents a clinicopathologically distinct PCNSL subtype, for which large studies and prognostic models are lacking. To address this gap, the International PCNSL Collaborative Group conducted an international retrospective multi-center study, integrating clinical, radiological, and pathological data from 308 ID-PCNSL, diagnosed at 23 participating sites in 7 countries. [...]

Glioblastoma (GBM) remains one of the most aggressive and treatment-resistant brain tumors in adults. Its immune microenvironment is dominated by tumor-associated macrophages, including both infiltrating monocytes and brain-resident microglia. [...]

Primary CNS T-cell lymphoma (PCNSTL) is an extremely rare and aggressive form of non-Hodgkin lymphoma. Diagnosis is often challenging because of the nonspecific clinical presentation, which can lead to delays in treatment. [...]

The lysine acetyltransferase (KAT) activity of p300/CREBBP has traditionally been linked to transcriptional activation. This has been attributed largely to acetylation of histone residues such as H3K27ac, a defining hallmark of active regulatory elements. [...]

Cyclin D-CDK4/6 is a component of mammalian cell-cycle machinery that drives cell proliferation. Small-molecule inhibitors of CDK4/6 have been approved for treatment of breast cancer patients. [...]

Traditional accuracy metrics no longer suffice for comparing diagnostic pathways for prostate cancer; new comparative performance metrics are needed that prioritize the overall benefit-to-harm ratio. Key performance metrics, such as biopsy efficiency, biopsy (grade) selectivity, and biopsy avoidance safety, enable meaningful patient-level comparisons across studies. [...]

Book Abstract: Wie Menschen gelebt haben und leben, hat sich sehr verändert, aber stets war und wird ihr Leben auch von Leid und Krankheit begleitet. Pionierinnen und Pioniere haben einiges gewagt, um dieses Leid zu lindern und Menschen besser vor Krankheiten schützen zu können. [...]

Book Abstract: Wie Menschen gelebt haben und leben, hat sich sehr verändert, aber stets war und wird ihr Leben auch von Leid und Krankheit begleitet. Pionierinnen und Pioniere haben einiges gewagt, um dieses Leid zu lindern und Menschen besser vor Krankheiten schützen zu können. [...]