Publications database

Background: Seamless, cross-sector information flow is prerequisite for personalized oncology, spanning the full patient journey from primary care and specialist practices to molecular tumor boards (MTBs) and back into follow-up care. However, patient-centered information between clinical encounters is often insufficiently captured and integrated into routine decision-making. [...]

Assessing data quality in federated health data systems presents unique challenges, particularly when data custodians cannot expose raw data due to privacy regulations. Traditional quality assessment approaches often require centralised access, which conflicts with the principles of data sovereignty and confidentiality.In this study, we evaluate the utility of federated data quality assessment with differential privacy techniques to safeguard sensitive health data. [...]

The aim of this secondary analysis of the BENEFIT randomized controlled trial was to investigate the effects of aerobic training (AT) or resistance training (RT) during neoadjuvant chemotherapy (NACT) on sleep and cancer-related fatigue (CRF), compared to a waitlist control group (WCG) that performed RT after surgery.In the BENEFIT study, 184 patients with breast cancer with scheduled NACT (mean age = 50 years, standard deviation = 11) were randomized to AT (n = 62), RT (n = 62), or WCG (n = 60). While the AT and RT groups trained during NACT (two supervised and one home-based session weekly), the WCG completed the same training as the RT group but only after breast surgery. [...]

Background: In nuclear medicine, numerous cancer types are treated via internal irradiation with radiopharmaceuticals, including low-LET (linear energy transfer) beta-emitting radionuclides like Lu-177. In most cases, such treatments lead to low-dose exposure of organ systems with β-irradiation, which induces only few isolated DSBs (double-strand breaks) in the nuclei of hit cells, the most threatening DNA damage type. [...]

Background/Objectives: Diffusion-weighted imaging (DWI) is a magnetic resonance technique used to map the apparent diffusion coefficient (ADC) of water in human tissue. ADC assessment plays a central role in clinical diagnostics, as malignant tissues typically exhibit reduced water mobility and, thus, lower ADC values. [...]

Diffuse large B cell lymphoma (DLBCL) is characterized by a variety of specific genetic alterations that impact signaling pathway dependencies and therapeutic outcomes. Among the recurrently mutated genes, we identified RHOA, a member of the small GTPase family, as a selective dependency in DLBCL. [...]

Meningiomas are the most common primary intracranial tumors, frequently requiring radiotherapy as a part of management. Effective radiotherapy planning for meningiomas necessitates accurate and consistent segmentation of target volumes on MRI, a process that is complex, labor-intensive, and dependent on expert expertise. [...]

Background/Objectives: [18F]Fluproxadine (formerly [18F]AF78) is a PET radiotracer targeting the norepinephrine transporter (NET) with potential applications in cardiac, neurological, and oncological imaging. Its guanidine moiety, while essential for NET binding, presents major radiosynthetic challenges due to high basicity and the harsh deprotection conditions required for protected precursors. [...]

The epidermis is uniquely exposed to the effects of environmental factors, such as ultraviolet radiation, which induce progressive genetic and epigenetic modifications contributing to aging and the onset of keratinocyte carcinomas. DNA methylation is the best-characterized epigenetic modification and a valuable biomarker for assessing epidermal health. [...]