Publications database

In the version of the article initially published, Fig. 3b included incorrect western blot datafor “MYC”, which was a duplication of “BCL-XL”. [...]

DNA-protein cross-links (DPCs) are highly toxic DNA lesions that block replication and transcription, but their impact on organismal physiology is unclear. We identified a role for the metalloprotease SPRTN in preventing DPC-driven immunity and its pathological consequences. [...]

Senescence is a tripartite cellular phenotype characterized by permanent growth arrest, resistance to apoptosis, and high secretory activity. Besides its physiological role in embryonic development and pathophysiological contribution to age-related tissue degeneration, in the context of tumor development senescence is an important suppressor mechanism, that counteracts accelerated proliferation. [...]

The COVID-19 pandemic has influenced healthcare systems worldwide, which is also evident in the treatment of -malignant melanoma. In this study, the effects of the pandemic on the incidence and depth of invasion of malignant melanoma of the skin were investigated. [...]

The last years have seen an acceleration in the development and uptake of artificial intelligence (AI) systems by 'early adopter' hospitals, caught between the pressures to 'perform' and 'transform' in a struggling health care system. This transformation has raised concerns among health care providers as their voices and location-specific workflows have often been overlooked, resulting in technologies that fail to integrate meaningfully into routine care and worsen rather than improve care processes. [...]

Organ transplant recipients (OTRs) face an elevated risk of skin cancer due to ultraviolet radiation (UVR) exposure and the need for chronic immunosuppression. Patient education is essential for early skin cancer detection and prevention. [...]

Gene regulatory changes are considered major drivers of evolutionary innovations, including the cerebellum's expansion during human evolution, yet they remain largely unexplored. In this study, we combined single-nucleus measurements of gene expression and chromatin accessibility from six mammals (human, bonobo, macaque, marmoset, mouse, and opossum) to uncover conserved and diverged regulatory networks in cerebellum development. [...]

225Ac-labeled prostate-specific membrane antigen (PSMA) radiopharmaceutical therapy (RPT) has emerged as a promising treatment option in advanced metastatic castration-resistant prostate cancer. We aimed to identify predictors for outcome including established clinical and PSMA-directed imaging parameters at baseline. [...]

The 'International Consensus Conference for Advanced Breast Cancer' was initiated with the rationale to standardize treatment of advanced breast cancer (ABC) based on available evidence. The aim was to ensure that all ABC patients worldwide receive adequate treatment and get access to new diagnostic, therapeutic, and supportive options.Since the beginning ABC Consensus Conference has been organized in Lisbon/Portugal. [...]

Pineal parenchymal body tumors are rare central nervous system tumors with a variety of presentations ranging from well-differentiated low-grade tumors to undifferentiated highly aggressive tumors. Recent molecular classification has described this heterogeneity, particularly among pineoblastomas (PB) and pineal parenchymal tumor of intermediate differentiation (PPTID).Our study analyzed 49 patients with pineal parenchymal tumors, including PBs (n = 39), papillary tumors of the pineal region (n = 5), PPTID (n = 2), pineocytoma (n = 1), and trilateral retinoblastoma (n = 2). [...]