Publications database

Large language models (LLMs) have transformative potential in radiology, including textual summaries, diagnostic decision support, proofreading, and image analysis. However, the rapid increase in studies investigating these models, along with the lack of standardized LLM-specific reporting practices, affects reproducibility, reliability, and clinical applicability. [...]

Molecular testing in NSCLC is essential for treatment selection, yet routine implementation remains inconsistent across institutions. Clinical evidence suggests that variability in testing may not be explained by patient or tumor characteristics but might be driven by institutional factors, potentially leading to adverse outcomes. [...]

Penile cancer is a rare, aggressive malignancy, with incidence varying geographically. The primary risk factor is human papillomavirus (HPV) infection. [...]

Management of advanced renal cell carcinoma (RCC) has evolved significantly in the last years. Systemic treatment of clear cell RCC, the predominant subtype, is performed with immune checkpoint inhibitors (ICIs), anti-VEGF tyrosine kinase inhibitor (TKI), HIF2α inhibitors and mTOR inhibitors.The application of ICI in early disease has raised new challenges regarding subsequent therapy strategies and management of new toxicities of immunotherapy-based combination therapies. [...]

Online adaptive proton therapy (OAPT) requires a fast plan optimization. Different optimization parameters of a commercial treatment planning system were investigated for OAPT of locally advanced non-small cell lung-cancer patients. [...]

Despite advances in multimodal therapy, survival in advanced head and neck squamous cell carcinoma (HNSCC) has improved only modestly. Tumor-informed circulating tumor DNA (ctDNA) assays allow early detection of molecular residual disease (MRD) and recurrence after curative treatment. [...]

For early detection of breast cancer, clinical palpation of the breast is offered yearly to all women aged 30 and older, and the German Mammography Screening Programme (MSP) offers biennial mammograms to all women aged 50 to 75 years. We investigated the utilization of both screening methods across various migrant groups in Germany, as well as the effect of German language proficiency.Cross-sectional data on participation frequencies from the baseline examination (2014 to 2019) of more than 100,000 women of the German National Cohort study (NAKO) were analysed by migrant status. [...]

Endoscopic screening for esophageal squamous neoplasia (ESN) is effective, but invasive and resource-intensive. We evaluated a minimally invasive capsule-sponge sampling with p53 immunohistochemistry (p53-IHC) for the early detection of ESN.In this prospective cross-sectional proof-of-concept study, participants from three predefined groups: (1) healthy controls, (2) high-risk individuals with prior head-and-neck cancer, and (3) patients with early-stage ESN scheduled for endoscopic treatment, underwent capsule-sponge sampling followed by high-definition endoscopy (reference diagnosis). [...]

Radiotherapy remains a mainstay of cancer treatment. However, radiotherapy can also elicit acute and chronic adverse effects, including dermal inflammation and skin fibrosis. [...]