Publications database

MicroRNAs (miRNAs) are key regulators of gene expression in both health and disease. Their expression and regulatory functions are highly complex and spatiotemporally organized within tissues. [...]

B-cell acute lymphoblastic leukemia (B-ALL) is characterized by the clonal expansion of immature lymphoblastic cells. Treating patients with disease relapse is challenging, especially after allogeneic stem cell transplantation (aSCT). [...]

Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease, with limited therapeutic options, few patients showing targetable molecular changes. New therapeutic strategies are necessary. [...]

Outcome patterns for stereotactic body radiotherapy (SBRT) of bone oligometastases (BoM) especially for older patients are inadequately defined. We aimed to evaluate oncological outcomes and tolerability of SBRT for BoM in older patients.Patients ≥70 years treated with SBRT for BoM between 2010 and 2024 at 20 European centers were analyzed and compared to patients <70 years. [...]

To improve accuracy and repeatability of myocardial 23Na quantification in cardiac MRI at 7 T by combining retrospective respiratory and cardiac motion correction with a novel anatomy-based B1 bias field correction.In this study, a dual-nuclear interleaved 23Na/1H MRI sequence at 7 T was applied. Here, 1H MR data enabled automated segmentation of myocardium and blood pool via nnUNet and facilitated respiratory and cardiac motion correction for both contrasts using 1H navigators. [...]

The HIT network was established in 2000 to create a population-based structure aiming to improve survival rates and reduce late effects for children with central nervous system (CNS) tumors by conducting comprehensive clinical trials.The HIT network currently consists of 10 coordinating trial centers mandated by the German Society for Pediatric Oncology and Hematology (GPOH) to conduct clinical trials and research projects, and to provide counseling to local centers for individual patients. The network is complemented by 11 reference centers (neuropathology, tumor biology, neuroradiology, pediatric neurosurgery, cerebrospinal fluid [CSF], assessments, radiotherapy, genetics), biostatistical support, and currently 72 local treatment sites.Numbers of children and adolescents with newly diagnosed CNS tumors registered to trials and registries increased from approximately 500 to more than 600 per year, corresponding to >95% of affected HIT-eligible children and adolescents in Germany. [...]

Precise glioma segmentation in magnetic resonance imaging (MRI) is essential for accurate diagnosis, optimal treatment planning, and advancing clinical research. However, most deep learning approaches require complete, standardized MRI protocols that are frequently unavailable in routine clinical practice. [...]

Background and Purpose: This study retrospectively evaluates the outcomes of head and neck adenoid cystic carcinomas (ACCs) treated with particle therapy, including carbon ion radiotherapy (CIRT) alone or combined with photon therapy, at a single institution. Methods and Materials: Patients with ACC who underwent CIRT alone or a combination of CIRT and photon therapy at the Marburg Ion Therapy Center between February 2017 and December 2023 were included. [...]

Background/Objectives: Treatment with immune checkpoint inhibitors (ICIs) in patients with advanced melanoma has greatly improved clinical outcomes but can induce immune-related adverse events (irAEs). ICI-induced immune-related (ir) colitis is one of the most common severe irAEs and is primarily managed by treatment with high-dose corticosteroids. [...]

The integration of artificial intelligence into pathology is transforming the assessment of histological and immunohistochemical (IHC) slides, offering opportunities to reduce variability and streamline diagnostics. In practical terms, most available tools and research models emulate the diagnostic capabilities of pathologists by detecting, grading, and classifying tumours and other diseases. [...]