Publications database

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2025-07-16
13:13
[DKFZ-2025-01382] Journal Article (Review Article)
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oDigital pathology biomarkers for guiding radiotherapy-based treatment concepts in prostate cancer - a systematic review and expert consensus.
Current risk-stratification systems for prostate cancer (PCa) do not sufficiently reflect the disease heterogeneity, and digital pathology (DP) combined with artificial intelligence (AI) tools (DP-AI) may offer a solution to this challenge. The aim of this work is to summarize the role of DP-AI for PCa patients treated with radiotherapy (RT), and to point out future areas of research. [...]

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2025-07-16
13:11
pmc [DKFZ-2025-01381] Journal Article
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Clinical Predictors and Recurrence Characteristics Following Radiotherapy for Primary Central Nervous System Lymphoma: A Retrospective Cohort Study.
Cancers 17(13), 2176 () [10.3390/cancers17132176]  GO
Background/Objectives: Primary central nervous system lymphoma (PCNSL) is a rare but aggressive tumor, primarily affecting elderly patients. Radiotherapy (RT) remains an important treatment option, particularly for patients who are ineligible for systemic chemotherapy. [...]

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2025-07-16
13:10
pmc [DKFZ-2025-01380] Journal Article
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Modeling the t(2;5) Translocation of Anaplastic Large Cell Lymphoma Using CRISPR-Mediated Chromosomal Engineering.
Cancers 17(13), 2226 () [10.3390/cancers17132226]  GO
ALK+ Anaplastic Large Cell Lymphoma (ALCL) is an aggressive T-cell lymphoma that is characterized by expression of the Anaplastic Lymphoma Kinase (ALK), which is induced by the t(2;5) chromosomal rearrangement, leading to the expression of the NPM-ALK fusion oncogene. Most previous preclinical models of ALK+ ALCL were based on overexpression of the NPM-ALK cDNA from heterologous promoters. [...]

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2025-07-16
13:08
DBCoverage [DKFZ-2025-01379] Journal Article
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Variability of Metabolic Rate and Distribution Volume Quantification in Whole-Body Parametric PATLAK [18F]-FDG PET/CT-A Prospective Trial in Patients with Lung Cancer.
Diagnostics 15(13), 1719 () [10.3390/diagnostics15131719]  GO
Background: The recent introduction of whole-body positron emission tomography/ computed tomography (PET/CT) scanners and multi-bed, multi-time point acquisition technique enable calculating fluorodeoxyglucose (FDG) kinetics in the whole body. However, validating parametric, Patlak-derived data is difficult on phantoms. [...]

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2025-07-16
13:04
[DKFZ-2025-01378] Journal Article
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Discovery of the First Highly Selective 1,4-dihydropyrido[3,4-b]pyrazin-3(2H)-one MKK4 Inhibitor.
Due to limited treatment options, liver failure remains a major challenge in modern medicine. With the validation of mitogen-activated protein kinase kinase 4 (MKK4, also known as MEK4 or MAP2K4) as a regulator of hepatocyte regeneration, a promising target for curative treatment of degenerative liver diseases was recently identified via in vivo RNAi experiments. [...]

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2025-07-16
12:58
DBCoverage [DKFZ-2025-01377] Journal Article
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Molecular determinants for recognition of serotonylated chromatin.
Nucleic acids research 53(13), gkaf612 () [10.1093/nar/gkaf612]  GO
Post-translational modifications of histone tails constitute a key epigenetic mechanism controlling chromatin environment and gene transcription. Serotonylation of histone H3Q5 (H3Q5ser) is a recently discovered mark associated with active transcription of RNA polymerase II (pol II)-transcribed genes. [...]

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2025-07-16
12:55
[DKFZ-2025-01376] Journal Article
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Multicenter multiplatform pattern-of-practice analysis of single-isocenter multitarget stereotactic radiosurgery.
Single-isocenter multitarget stereotactic radiosurgery (SIMT SRS) offers enhanced clinical efficiency for treating multiple brain metastases. However, it introduces additional uncertainties, such as off-center dose and beam profile inaccuracies, as well as quality assurance (QA) challenges, complicating its implementation. [...]

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2025-07-16
12:52
[DKFZ-2025-01375] Journal Article
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Anatomic Staging of H3 G34-Mutant Diffuse Hemispheric Glioma.
Neurology 105(3), e213861 () [10.1212/WNL.0000000000213861]  GO
H3 G34-mutant diffuse hemispheric gliomas are rare, aggressive primary brain tumors predominantly affecting young patients. We investigated the prognostic value of anatomic staging (AS)-a system previously validated in adult-type diffuse gliomas-in this molecularly distinct tumor type.Patients from an international cohort with H3 G34-mutant gliomas underwent AS based on pretreatment imaging, performed independently by 2 raters blinded to clinical outcomes. [...]

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2025-07-16
12:50
[DKFZ-2025-01374] Journal Article
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A cereblon-based glue degrader of NEK7 regulates NLRP3 inflammasome in a context-dependent manner.
Aberrant NLRP3 (NACHT-, leucine-rich repeat [LRR]- and pyrin domain [PYD]- containing protein 3) inflammasome activation is linked to many inflammatory diseases, driving the search for therapeutics inhibiting this pathway. NEK7 is proposed to mediate NLRP3 inflammasome assembly and activation by bridging adjacent NLRP3 subunits. [...]

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2025-07-16
12:48
[DKFZ-2025-01373] Journal Article
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Image-Derived Blood Normalization of Antibody-Based TREM2 PET in Mouse Models of Amyloidosis and Myocardial Infarction.
The triggering receptor expressed on myeloid cells 2 (TREM2) plays a pivotal role in the activation of myeloid cells and is currently being investigated as a potential therapeutic target in several diseases. In this study, we established enhanced quantification of PET images of a 64Cu-labeled antibody-based PET radiotracer as a noninvasive tool for the assessment of TREM2 expression in the brain and peripheral organs of mice. [...]

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