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2023-02-08
15:40
[DKFZ-2023-00301] Journal Article
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Flt3- and Tie2-Cre tracing identifies regeneration in sepsis from multipotent progenitors but not hematopoietic stem cells.
Cell stem cell 30(2), 207 - 218.e7 () [10.1016/j.stem.2022.12.014]  GO
In response to infections and stress, hematopoiesis rapidly enhances blood and immune cell production. The stage within the hematopoietic hierarchy that accounts for this regeneration is unclear under natural conditions in vivo. [...]

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2023-02-08
15:35
[DKFZ-2023-00300] Journal Article (Review Article)
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NOTCH3 missense mutations as predictor of long-term response to gemcitabine in a patient with epithelioid hemangioendothelioma.
Epithelioid hemangioendothelioma (EHE) as a very rare malignant vascular tumor belongs to the heterogenous group of soft-tissue sarcomas. Depending on the clinical course of the disease, interdisciplinary treatment concepts are required, including surgery, radiotherapy and systemic cancer therapy. [...]

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2023-02-08
15:25
[DKFZ-2023-00299] Journal Article
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USP47 deubiquitylates Groucho/TLE to promote Wnt-β-catenin signaling.
Science signaling 16(771), eabn8372 () [10.1126/scisignal.abn8372]  GO
The Wnt-β-catenin signal transduction pathway is essential for embryonic development and adult tissue homeostasis. Wnt signaling converts TCF from a transcriptional repressor to an activator in a process facilitated by the E3 ligase XIAP. [...]

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2023-02-07
15:17
[DKFZ-2023-00289] Journal Article
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A genome-wide RNAi screen for genes important for proliferation of cultured Drosophila cells at low temperature identifies the Ball/VRK protein kinase.
A change in ambient temperature is predicted to disrupt cellular homeostasis by affecting all cellular processes in an albeit non-uniform manner. Diffusion is generally less temperature-sensitive than enzymes, for example, and each enzyme has a characteristic individual temperature profile. [...]

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