In process

Ewing sarcoma is a rare, fusion-driven malignancy with poor prognosis in the metastatic setting, for which no established immunotherapeutic treatment is currently available. Fusion breakpoints are rational precision immunotherapy targets, yet clinical evidence of immunogenicity is scarce. [...]

Vision-language models (VLMs) hold promise for video-based surgical decision support tasks due to their capabilities to understand complex temporospatial (video) data. However, the same multimodal interfaces that enable such capabilities also introduce new vulnerabilities to manipulations through embedded deceptive text or images (prompt injection attacks). [...]

Allogeneic chimeric antigen receptor (CAR) T cell therapies offer a scalable, off-the-shelf option for cancer treatment, but their clinical use is limited by the risk of graft-versus-host disease (GvHD), mediated by the endogenous T cell receptor (TCR). Conventional strategies to eliminate TCR expression rely on genome editing tools such as CRISPR-Cas9 or base editing, which introduce permanent DNA changes and pose safety concerns. [...]